Improving the affinity of SL0101 for RSK using structure-based design. (Q30421848)

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26 February 2020

title

Improving the affinity of SL0101 for RSK using structure-based design (English)

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26 February 2020

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26 February 2020

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26 February 2020

Deborah A Lannigan

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26 February 2020

Sidney M Hecht

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26 February 2020

Roman M Mrozowski

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26 February 2020

Rajender Vemula

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26 February 2020

Qi Zhang

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26 February 2020

Benjamin R Schroeder

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26 February 2020

Michael K Hilinski

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26 February 2020

David E Clark

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26 February 2020

publication date

1 February 2012

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ACS Medicinal Chemistry Letters

26 February 2020

published in

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26 February 2020

volume

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26 February 2020

issue

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26 February 2020

page(s)

175-179

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Insights into the inhibition of the p90 ribosomal S6 kinase (RSK) by the flavonol glycoside SL0101 from the 1.5 Å crystal structure of the N-terminal domain of RSK2 with bound inhibitor

26 February 2020

cites work

1 reference

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Analogs of the RSK inhibitor SL0101: optimization of in vitro biological stability

20 June 2018

1 reference

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Synthesis and Evaluation of the α-D-/α-L-Rhamnosyl and Amicetosyl Digitoxigenin Oligomers as Anti-tumor Agents

20 June 2018

1 reference

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Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell

20 June 2018

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An siRNA screen identifies RSK1 as a key modulator of lung cancer metastasis

20 June 2018

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A Direct Comparison of the Anticancer Activities of Digitoxin MeON-Neoglycosides and O-Glycosides: Oligosaccharide Chain Length-Dependent Induction of Caspase-9-Mediated Apoptosis

20 June 2018

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Synthesis of several cleistrioside and cleistetroside natural products via a divergent de novo asymmetric approach

20 June 2018

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A de novo approach to the synthesis of glycosylated methymycin analogues with structural and stereochemical diversity

20 June 2018

1 reference

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Synthesis of SL0101 carbasugar analogues: carbasugars via Pd-catalyzed cyclitolization and post-cyclitolization transformations

20 June 2018

1 reference

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RSK in tumorigenesis: connections to steroid signaling

20 June 2018

1 reference

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RSK is a principal effector of the RAS-ERK pathway for eliciting a coordinate promotile/invasive gene program and phenotype in epithelial cells

20 June 2018

1 reference

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The RSK family of kinases: emerging roles in cellular signalling

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3601785

Codependent functions of RSK2 and the apoptosis-promoting factor TIA-1 in stress granule assembly and cell survival

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3601785

The de novo synthesis of oligosaccharides: application to the medicinal chemistry SAR-study of digitoxin

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3601785

The selectivity of protein kinase inhibitors: a further update

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3601785

Structural basis for the activity of the RSK-specific inhibitor, SL0101.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3601785

De novo asymmetric syntheses of SL0101 and its analogues via a palladium-catalyzed glycosylation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3601785

Influence of rhamnose substituents on the potency of SL0101, an inhibitor of the Ser/Thr kinase, RSK.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3601785

The serine/threonine protein kinase, p90 ribosomal S6 kinase, is an important regulator of prostate cancer cell proliferation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3601785

Synthesis of a potent and selective inhibitor of p90 Rsk.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3601785

Identification of the first specific inhibitor of p90 ribosomal S6 kinase (RSK) reveals an unexpected role for RSK in cancer cell proliferation

20 June 2018

1 reference

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Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase.

20 June 2018

1 reference

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C5'-Alkyl Substitution Effects on Digitoxigenin α-l-Glycoside Cancer Cytotoxicity

20 June 2018

1 reference

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Total synthesis of jadomycin A and a carbasugar analogue of jadomycin B.

26 November 2018

1 reference

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Syntheses of four D- and L-hexoses via diastereoselective and enantioselective dihydroxylation reactions

26 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23519677

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/ML300298V

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26 February 2020

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26 February 2020

PubMed publication ID

23519677

1 reference

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