Randomized, Placebo-controlled Clinical Trial of an Aerosolized β2-Agonist for Treatment of Acute Lung Injury (Q30425088)

3 September 2017

1 reference

Randomized, placebo-controlled clinical trial of an aerosolized β₂-agonist for treatment of acute lung injury (English)

1 reference

3 September 2017

Randomized, Placebo-controlled Clinical Trial of an Aerosolized β2-Agonist for Treatment of Acute Lung Injury (English)

1 reference

10.1164/RCCM.201012-2090OC

DOI

https://api.crossref.org/works/10.1164/RCCM.201012-2090OC

1 December 2024

0 references

0 references

1 reference

Michael A Matthay

1 reference

3 September 2017

Kathleen D Liu

1 reference

ORCID Public Data File 2021

3 September 2017

Ivor S Douglas

1 reference

Mark David Eisner

object named as

Mark Eisner

1 reference

3 September 2017

National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network

1 reference

3 September 2017

Shannon Carson

1 reference

3 September 2017

Duncan Hite

1 reference

3 September 2017

Steven Holets

1 reference

3 September 2017

Neil MacIntyre

1 reference

3 September 2017

Marc Moss

1 reference

3 September 2017

David Schoenfeld

1 reference

3 September 2017

Jay Steingrub

1 reference

3 September 2017

Michael A. Matthay

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21562125

1 December 2024

Roy G. Brower

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21562125

1 December 2024

Mark Eisner

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21562125

1 December 2024

Richard H. Kallet

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21562125

1 December 2024

B. Taylor Thompson

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21562125

1 December 2024

language of work or name

English

0 references

publication date

1 September 2011

1 reference

full work available at URL

3 September 2017

https://europepmc.org/articles/pmc3175548?pdf=render

file format

Portable Document Format

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21562125

https://europepmc.org/articles/PMC3175548

1 December 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21562125

https://europepmc.org/articles/PMC3175548?pdf=render

1 December 2024

file format

Portable Document Format

online access status

open access

content deliverer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21562125

https://doi.org/10.1164/rccm.201012-2090oc

1 December 2024

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21562125

https://www.atsjournals.org/doi/pdf/10.1164/rccm.201012-2090OC

1 December 2024

1 reference

10.1164/RCCM.201012-2090OC

DOI

https://api.crossref.org/works/10.1164/RCCM.201012-2090OC

American Journal of Respiratory and Critical Care Medicine

1 December 2024

published in

1 reference

3 September 2017

184

1 reference

3 September 2017

1 reference

3 September 2017

561-568

1 reference

Beyond mortality: future clinical research in acute lung injury

3 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175548

Acute lung injury edema fluid decreases net fluid transport across human alveolar epithelial type II cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175548

Physiological and biochemical markers of alveolar epithelial barrier dysfunction in perfused human lungs

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175548

Utilization of bronchodilators in ventilated patients without obstructive airways disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175548

Comparison of two fluid-management strategies in acute lung injury

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175548

Functional ion channels in pulmonary alveolar type I cells support a role for type I cells in lung ion transport

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175548

Alveolar epithelial ion and fluid transport: recent progress

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175548

Stimulation of alveolar epithelial fluid clearance in human lungs by exogenous epinephrine

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175548

Mechanisms of pulmonary edema clearance

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175548

Interleukin-1beta decreases expression of the epithelial sodium channel alpha-subunit in alveolar epithelial cells via a p38 MAPK-dependent signaling pathway

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175548

Effect of beta-adrenergic agonists on mucociliary clearance

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175548

Fas and fas ligand are up-regulated in pulmonary edema fluid and lung tissue of patients with acute lung injury and the acute respiratory distress syndrome

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175548

Aerosolized beta(2)-adrenergic agonists achieve therapeutic levels in the pulmonary edema fluid of ventilated patients with acute respiratory failure

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175548

Lung epithelial fluid transport and the resolution of pulmonary edema

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175548

Novel role for CFTR in fluid absorption from the distal airspaces of the lung

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175548

Alveolar epithelial transport. Basic science to clinical medicine

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175548

The effect of polymorphisms of the beta(2)-adrenergic receptor on the response to regular use of albuterol in asthma

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175548

The acute respiratory distress syndrome

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175548

Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175548

Alveolar fluid clearance in the resected human lung

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175548

Intact epithelial barrier function is critical for the resolution of alveolar edema in humans

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175548

Alterations of the gas exchange apparatus in adult respiratory insufficiency associated with septicemia

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175548

Alveolar fluid clearance is impaired in the majority of patients with acute lung injury and the acute respiratory distress syndrome

20 June 2018

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.201012-2090OC

Transforming growth factor-beta1 decreases expression of the epithelial sodium channel alphaENaC and alveolar epithelial vectorial sodium and fluid transport via an ERK1/2-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.201012-2090OC

beta(2)-Agonists for treatment of pulmonary edema: ready for clinical studies?

21 January 2018

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.201012-2090OC

Beta-adrenergic agonist therapy as a potential treatment for acute lung injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.201012-2090OC

The beta-agonist lung injury trial (BALTI): a randomized placebo-controlled clinical trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.201012-2090OC

Clinically relevant concentrations of beta2-adrenergic agonists stimulate maximal cyclic adenosine monophosphate-dependent airspace fluid clearance and decrease pulmonary edema in experimental acid-induced lung injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.201012-2090OC

Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.201012-2090OC

Impaired alveolar liquid clearance after 48-h isoproterenol infusion spontaneously recovers by 96 h of continuous infusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.201012-2090OC

Effect of bronchodilators on lung mechanics in the acute respiratory distress syndrome (ARDS).

21 January 2018

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.201012-2090OC

Selected contribution: long-term effects of beta(2)-adrenergic receptor stimulation on alveolar fluid clearance in mice

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175548

When is a negative phase II trial truly negative?

26 November 2018

1 reference

12 December 2020

Low tidal volume reduces epithelial and endothelial injury in acid-injured rat lungs

1 reference

12 December 2020

Effects of albuterol inhalation on the work of breathing during weaning from mechanical ventilation

1 reference

12 December 2020

Vascular permeability and epithelial transport effects on lung edema formation in ischemia and reperfusion

1 reference

12 December 2020

Beta-adrenergic agonist stimulated alveolar fluid clearance in ex vivo human and rat lungs

1 reference

12 December 2020

Modulation of alveolar fluid clearance by reactive oxygen-nitrogen intermediates

1 reference

12 December 2020

10.1164/RCCM.201012-2090OC

Identifiers

DOI

1 reference

3 September 2017

1 reference

3 September 2017

1 reference