The Rho-guanine nucleotide exchange factor Trio controls leukocyte transendothelial migration by promoting docking structure formation. (Q30424519)

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5 February 2020

title

The Rho-guanine nucleotide exchange factor Trio controls leukocyte transendothelial migration by promoting docking structure formation (English)

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5 February 2020

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5 February 2020

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5 February 2020

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5 February 2020

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5 February 2020

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5 February 2020

Mark Hoogenboezem

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5 February 2020

Floris P J van Alphen

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5 February 2020

Renske J de Jong

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5 February 2020

Elena Kostadinova

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publication date

13 June 2012

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Molecular Biology of the Cell

5 February 2020

published in

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volume

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issue

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page(s)

2831-2844

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The N-terminal DH-PH domain of Trio induces cell spreading and migration by regulating lamellipodia dynamics in a Rac1-dependent fashion

5 February 2020

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Neisseria meningitidis infection of human endothelial cells interferes with leukocyte transmigration by preventing the formation of endothelial docking structures

20 June 2018

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Targeting and activation of Rac1 are mediated by the exchange factor beta-Pix

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20 June 2018

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Multiple novel isoforms of Trio are expressed in the developing rat brain

20 June 2018

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Phagocytosis of apoptotic cells is regulated by a UNC-73/TRIO-MIG-2/RhoG signaling module and armadillo repeats of CED-12/ELMO

20 June 2018

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Coordinated redistribution of leukocyte LFA-1 and endothelial cell ICAM-1 accompany neutrophil transmigration

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20 June 2018

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20 June 2018

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20 June 2018

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20 June 2018

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20 June 2018

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20 June 2018

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The Rac1- and RhoG-specific GEF domain of Trio targets filamin to remodel cytoskeletal actin

20 June 2018

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20 June 2018

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20 June 2018

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TrioGEF1 controls Rac- and Cdc42-dependent cell structures through the direct activation of rhoG

20 June 2018

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Lymphocyte migration through brain endothelial cell monolayers involves signaling through endothelial ICAM-1 via a rho-dependent pathway

20 June 2018

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The small GTPase RalA targets filamin to induce filopodia

20 June 2018

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20 June 2018

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ICAM-1 signaling pathways associated with Rho activation in microvascular brain endothelial cells.

20 June 2018

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20 June 2018

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20 June 2018

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Translocation of cortactin to the cell periphery is mediated by the small GTPase Rac1

20 June 2018

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The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains

20 June 2018

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Endothelial cell cytosolic free calcium regulates neutrophil migration across monolayers of endothelial cells

20 June 2018

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Intercellular adhesion molecule 1 activation induces tyrosine phosphorylation of the cytoskeleton-associated protein cortactin in brain microvessel endothelial cells.

20 June 2018

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20 June 2018

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Evidence of a functional role for interaction between ICAM-1 and nonmuscle alpha-actinins in leukocyte diapedesis.

20 June 2018

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T-cell interaction with ICAM-1/ICAM-2 double-deficient brain endothelium in vitro: the cytoplasmic tail of endothelial ICAM-1 is necessary for transendothelial migration of T cells

21 January 2018

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Endothelial LSP1 is involved in endothelial dome formation, minimizing vascular permeability changes during neutrophil transmigration in vivo

21 January 2018

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Analysis of low molecular weight GTPase activity in endothelial cell cultures

21 January 2018

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Monocyte adhesion and spreading on human endothelial cells is dependent on Rho-regulated receptor clustering

21 January 2018

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Endothelial adapter proteins in leukocyte transmigration.

21 January 2018

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Analysis of the roles of ICAM-1 in neutrophil transmigration using a reconstituted mammalian cell expression model: implication of ICAM-1 cytoplasmic domain and Rho-dependent signaling pathway

26 November 2018

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12 December 2020

Endothelial cell cortactin coordinates intercellular adhesion molecule-1 clustering and actin cytoskeleton remodeling during polymorphonuclear leukocyte adhesion and transmigration

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12 December 2020

ICAM-1-mediated, Src- and Pyk2-dependent vascular endothelial cadherin tyrosine phosphorylation is required for leukocyte transendothelial migration

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12 December 2020

Activated leukocyte cell adhesion molecule promotes leukocyte trafficking into the central nervous system

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12 December 2020

Identifiers

DOI

10.1091/MBC.E11-11-0907

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22696684%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22696684%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

PubMed publication ID

22696684

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22696684%20AND%20SRC:MED&resulttype=core&format=json