Lgr5+ cells regenerate hair cells via proliferation and direct transdifferentiation in damaged neonatal mouse utricle (Q30401408)

12 September 2017

Lgr5+ cells regenerate hair cells via proliferation and direct transdifferentiation in damaged neonatal mouse utricle (English)

1 reference

12 September 2017

Lisa L Cunningham

0 references

Tian Wang

1 reference

12 September 2017

Renjie Chai

1 reference

12 September 2017

Grace S Kim

1 reference

12 September 2017

Nicole Pham

1 reference

12 September 2017

Lina Jansson

1 reference

12 September 2017

Duc-Huy Nguyen

1 reference

12 September 2017

Bryan Kuo

1 reference

12 September 2017

Lindsey A May

1 reference

12 September 2017

Jian Zuo

1 reference

12 September 2017

Alan G Cheng

1 reference

12 September 2017

language of work or name

English

0 references

publication date

7 April 2015

1 reference

12 September 2017

Nature Communications

1 reference

12 September 2017

1 reference

12 September 2017

6613

1 reference

Parallel states of pathological Wnt signaling in neonatal brain injury and colon cancer

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391285

Spontaneous hair cell regeneration in the neonatal mouse cochlea in vivo

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391285

Interfollicular epidermal stem cells self-renew via autocrine Wnt signaling.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391285

Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391285

Generation of hair cells in neonatal mice by β-catenin overexpression in Lgr5-positive cochlear progenitors

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391285

Engineered deafness reveals that mouse courtship vocalizations do not require auditory experience

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391285

Tympanic border cells are Wnt-responsive and can act as progenitors for postnatal mouse cochlear cells.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391285

In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391285

Notch inhibition induces cochlear hair cell regeneration and recovery of hearing after acoustic trauma

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391285

Synaptic profiles during neurite extension, refinement and retraction in the developing cochlea

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391285

A dual function for canonical Wnt/β-catenin signaling in the developing mammalian cochlea

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391285

Hair cell replacement in adult mouse utricles after targeted ablation of hair cells with diphtheria toxin

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391285

Wnt5a potentiates TGF-β signaling to promote colonic crypt regeneration after tissue injury

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391285

Developmental stage and time dictate the fate of Wnt/β-catenin-responsive stem cells in the mammary gland

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391285

Wnt-responsive Lgr5-expressing stem cells are hair cell progenitors in the cochlea

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391285

Over half the hair cells in the mouse utricle first appear after birth, with significant numbers originating from early postnatal mitotic production in peripheral and striolar growth zones

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391285

In vivo proliferative regeneration of balance hair cells in newborn mice

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391285

Wnt signaling induces proliferation of sensory precursors in the postnatal mouse cochlea

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391285

Inhibition of Notch activity promotes nonmitotic regeneration of hair cells in the adult mouse utricles

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391285

Dynamic expression of Lgr5, a Wnt target gene, in the developing and mature mouse cochlea

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391285

Wnt proteins promote bone regeneration

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391285

Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391285

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391285

Cell-specific inducible gene recombination in postnatal inner ear supporting cells and glia

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391285

Quo vadis, hair cell regeneration?

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391285

Spontaneous hair cell regeneration in the mouse utricle following gentamicin ototoxicity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391285

Recent advances in hair cell regeneration research

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391285

Sox2 and JAGGED1 expression in normal and drug-damaged adult mouse inner ear.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391285

Identification of stem cells in small intestine and colon by marker gene Lgr5

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391285

Hair cell regeneration in the avian auditory epithelium.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391285

Expression of LHX3 and SOX2 during mouse inner ear development

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391285

Differential distribution of stem cells in the auditory and vestibular organs of the inner ear.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391285

Auditory hair cell replacement and hearing improvement by Atoh1 gene therapy in deaf mammals

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391285

Developmental acquisition of voltage-dependent conductances and sensory signaling in hair cells of the embryonic mouse inner ear.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391285

The Wnt signaling pathway in development and disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391285

Direct transdifferentiation gives rise to the earliest new hair cells in regenerating avian auditory epithelium

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391285

Defining the epithelial stem cell niche in skin

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391285

Math1 gene transfer generates new cochlear hair cells in mature guinea pigs in vivo

20 June 2018

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391285

20 June 2018

https://api.crossref.org/works/10.1038%2FNCOMMS7613

7 January 2021

inferred from DOI database lookup

Hair cell regeneration: winging our way towards a sound future.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391285

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391285

The deaf jerker mouse has a mutation in the gene encoding the espin actin-bundling proteins of hair cell stereocilia and lacks espins.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391285

Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391285

Hair cell recovery in the vestibular sensory epithelia of mature guinea pigs

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391285

Analysis of small hair bundles in the utricles of mature guinea pigs

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391285

Regenerative proliferation in inner ear sensory epithelia from adult guinea pigs and humans

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391285

Morphological correlates of functional recovery in the chicken inner ear after gentamycin treatment

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391285

Diffusible factors regulate hair cell regeneration in the avian inner ear.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391285

Induction of cell proliferation in mammalian inner-ear sensory epithelia by transforming growth factor alpha and epidermal growth factor

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391285

Hair cell regeneration after acoustic trauma in adult Coturnix quail

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391285

Regeneration of sensory hair cells after acoustic trauma

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391285

Lgr5 marks cycling, yet long-lived, hair follicle stem cells.

20 June 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7613

Hair cell regeneration after streptomycin toxicity in the avian vestibular epithelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7613

Oncomodulin identifies different hair cell types in the mammalian inner ear.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7613

Ultrastructural analysis of [3H]thymidine-labeled cells in the rat utricular macula

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7613

Morphological evidence for supporting cell to hair cell conversion in the mammalian utricular macula

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7613

Pluripotent stem cells from the adult mouse inner ear.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7613

Overexpression of Math1 induces robust production of extra hair cells in postnatal rat inner ears

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7613

Vestibular hair cell regeneration and restoration of balance function induced by math1 gene transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7613

Inducible site-specific recombination in myelinating cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7613

Imaging calcium entry sites and ribbon structures in two presynaptic cells.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391285

Caspase activation in hair cells of the mouse utricle exposed to neomycin.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391285

Mammalian vestibular hair cell regeneration

26 November 2018

1 reference

12 December 2020

Postnatal development of type I and type II hair cells in the mouse utricle: acquisition of voltage-gated conductances and differentiated morphology

1 reference

12 December 2020

Distribution and time course of hair cell regeneration in the pigeon utricle

1 reference

12 December 2020

Development of short latency vestibular evoked potentials in the neonatal rat

1 reference

12 December 2020

Development of the inner ear of the mouse: a radioautographic study of terminal mitoses

1 reference

12 December 2020

Development of the utricular macula in the mouse

1 reference

12 December 2020

The avian inner ear. Continuous production of hair cells in vestibular sensory organs, but not in the auditory papilla

1 reference

12 December 2020

Ongoing production of sensory cells in the vestibular epithelium of the chick

1 reference

12 December 2020

Ultrastructural evidence for hair cell regeneration in the mammalian inner ear

1 reference

12 December 2020

Identifiers

DOI

10.1038/NCOMMS7613

1 reference

Dimensions Publication ID

12 September 2017

0 references

0 references

1 reference

12 September 2017

PubMed publication ID

25849379

1 reference