In search of new lead compounds for trypanosomiasis drug design: a protein structure-based linked-fragment approach. (Q30351707)

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English	In search of new lead compounds for trypanosomiasis drug design: a protein structure-based linked-fragment approach.	scientific article

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scholarly article

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PubMed publication ID

1624956

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20 June 2017

title

In search of new lead compounds for trypanosomiasis drug design: a protein structure-based linked-fragment approach. (English)

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Europe PubMed Central

PubMed publication ID

1624956

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20 June 2017

main subject

protein design

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trypanosomiasis

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protein structure

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author name string

Verlinde CL

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1

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Europe PubMed Central

PubMed publication ID

1624956

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20 June 2017

Rudenko G

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2

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Europe PubMed Central

PubMed publication ID

1624956

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20 June 2017

Hol WG

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3

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Europe PubMed Central

PubMed publication ID

1624956

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20 June 2017

language of work or name

English

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publication date

1 April 1992

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Europe PubMed Central

PubMed publication ID

1624956

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20 June 2017

published in

Journal of Computer - Aided Molecular Design

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Europe PubMed Central

PubMed publication ID

1624956

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20 June 2017

volume

6

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Europe PubMed Central

PubMed publication ID

1624956

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20 June 2017

issue

2

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Europe PubMed Central

PubMed publication ID

1624956

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20 June 2017

page(s)

131-147

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Europe PubMed Central

PubMed publication ID

1624956

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20 June 2017

cites work

Human triosephosphate isomerase cDNA and protein structure. Studies of triosephosphate isomerase deficiency in man

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/1624956

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12 December 2020

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Refined 1.83 A structure of trypanosomal triosephosphate isomerase crystallized in the presence of 2.4 M-ammonium sulphate. A comparison with the structure of the trypanosomal triosephosphate isomerase-glycerol-3-phosphate complex

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/1624956

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12 December 2020

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2:4-diaminopyrimidines- a new series of antimalarials

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/1624956

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12 December 2020

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Malaria: resurgence in research brightens prospects

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PubMed

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12 December 2020

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Anion binding at the active site of trypanosomal triosephosphate isomerase. Monohydrogen phosphate does not mimic sulphate

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/1624956

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12 December 2020

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Chicken triosephosphate isomerase complements an Escherichia coli deficiency

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/1624956

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12 December 2020

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New hydrogen-bond potentials for use in determining energetically favorable binding sites on molecules of known structure

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/1624956

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12 December 2020

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Compartmentation of carbohydrate metabolism in trypanosomes

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PubMed

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12 December 2020

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Design, activity, and 2.8 A crystal structure of a C2 symmetric inhibitor complexed to HIV-1 protease

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/1624956

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12 December 2020

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Refolding of triose phosphate isomerase

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/1624956

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12 December 2020

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Reconciling the magnitude of the microscopic and macroscopic hydrophobic effects

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/1624956

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12 December 2020

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inferred from PubMed ID database lookup

Kinetic properties of triose-phosphate isomerase from Trypanosoma brucei brucei. A comparison with the rabbit muscle and yeast enzymes

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/1624956

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12 December 2020

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Using shape complementarity as an initial screen in designing ligands for a receptor binding site of known three-dimensional structure.

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/1624956

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12 December 2020

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ALADDIN: an integrated tool for computer-assisted molecular design and pharmacophore recognition from geometric, steric, and substructure searching of three-dimensional molecular structures

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/1624956

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12 December 2020

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Areas, volumes, packing and protein structure

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/1624956

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure-based design of nonpeptide inhibitors specific for the human immunodeficiency virus 1 protease

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/1624956

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12 December 2020

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Biochemical changes associated with alpha-difluoromethylornithine uptake and resistance in Trypanosoma brucei

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/1624956

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12 December 2020

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Stabilization of a reaction intermediate as a catalytic device: definition of the functional role of the flexible loop in triosephosphate isomerase.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/1624956

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12 December 2020

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Glycolytic enzymes of Trypanosoma brucei. Simultaneous purification, intraglycosomal concentrations and physical properties

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/1624956

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12 December 2020

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The adaptability of the active site of trypanosomal triosephosphate isomerase as observed in the crystal structures of three different complexes

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https://pubmed.ncbi.nlm.nih.gov/1624956

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12 December 2020

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Automated site-directed drug design: approaches to the formation of 3D molecular graphs.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/1624956

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12 December 2020

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Crystallographic and molecular modeling studies on trypanosomal triosephosphate isomerase: a critical assessment of the predicted and observed structures of the complex with 2-phosphoglycerate

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/1624956

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12 December 2020

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Clinical and pathological aspects of human African trypanosomiasis (T. b. gambiense) with particular reference to reactive arsenical encephalopathy

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/1624956

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12 December 2020

based on heuristic

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Structure determination of the glycosomal triosephosphate isomerase from Trypanosoma brucei brucei at 2.4 A resolution

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/1624956

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Automated site-directed drug design: the concept of spacer skeletons for primary structure generation.

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/1624956

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12 December 2020

based on heuristic

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A computational procedure for determining energetically favorable binding sites on biologically important macromolecules

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/1624956

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation of hen's egg phosphonolipids by thin-layer chromatography, their identification and silicic acid column chromatographic separation

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/1624956

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of the gene for the microbody (glycosomal) triosephosphate isomerase of Trypanosoma brucei

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/1624956

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Searching for pharmacophores in large coordinate data bases and its use in drug design

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/1624956

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure of chicken muscle triose phosphate isomerase determined crystallographically at 2.5Å resolution: using amino acid sequence data

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/1624956

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12 December 2020

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Identifiers

DOI

10.1007/BF00129424

1 reference

stated in

Europe PubMed Central

PubMed publication ID

1624956

retrieved

20 June 2017

DBLP publication ID

journals/jcamd/VerlindeRH92

1 reference

stated in

DBLP Dataset 2021-01-02

retrieved

28 January 2021

PubMed publication ID

1624956

1 reference

stated in

Europe PubMed Central

PubMed publication ID

1624956

retrieved

20 June 2017

 

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