Mapping a molecular link between allosteric inhibition and activation of the glycine receptor. (Q39937407)

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14 January 2020

title

Mapping a molecular link between allosteric inhibition and activation of the glycine receptor (English)

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14 January 2020

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14 January 2020

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14 January 2020

Trevor G Smart

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14 January 2020

publication date

21 September 2008

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Nature Structural & Molecular Biology

14 January 2020

published in

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14 January 2020

volume

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issue

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14 January 2020

page(s)

1084-1093

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Refined structure of the nicotinic acetylcholine receptor at 4A resolution

14 January 2020

cites work

1 reference

Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors

21 January 2018

1 reference

Interfaces and the driving force of hydrophobic assembly

21 January 2018

1 reference

Nicotinic receptors at the amino acid level

21 January 2018

1 reference

Cys-loop receptors: new twists and turns

21 January 2018

1 reference

Recent advances in Cys-loop receptor structure and function

21 January 2018

1 reference

A gating mechanism proposed from a simulation of a human alpha7 nicotinic acetylcholine receptor

21 January 2018

1 reference

Nicotine and carbamylcholine binding to nicotinic acetylcholine receptors as studied in AChBP crystal structures

21 January 2018

1 reference

Agonist-induced conformational changes in the extracellular domain of alpha 7 nicotinic acetylcholine receptors

21 January 2018

1 reference

Acetylcholine receptor gating: movement in the alpha-subunit extracellular domain

21 January 2018

1 reference

Crystal structure of the extracellular domain of nAChR alpha1 bound to alpha-bungarotoxin at 1.94 A resolution

21 January 2018

1 reference

Gating dynamics of the acetylcholine receptor extracellular domain.

21 January 2018

1 reference

Activation of the nicotinic acetylcholine receptor involves a switch in conformation of the alpha subunits.

21 January 2018

1 reference

Implications of the quaternary twist allosteric model for the physiology and pathology of nicotinic acetylcholine receptors

21 January 2018

1 reference

An intersubunit trigger of channel gating in the muscle nicotinic receptor.

21 January 2018

1 reference

Hyperekplexia phenotype of glycine receptor alpha1 subunit mutant mice identifies Zn(2+) as an essential endogenous modulator of glycinergic neurotransmission

21 January 2018

1 reference

Modulation by zinc ions of native rat and recombinant human inhibitory glycine receptors

21 January 2018

1 reference

Molecular basis for zinc potentiation at strychnine-sensitive glycine receptors

21 January 2018

1 reference

Identification of an inhibitory Zn2+ binding site on the human glycine receptor alpha1 subunit.

21 January 2018

1 reference

Insights into the structural basis for zinc inhibition of the glycine receptor

21 January 2018

1 reference

Molecular determinants of glycine receptor alphabeta subunit sensitivities to Zn2+-mediated inhibition

21 January 2018

1 reference

Crystal structure of nicotinic acetylcholine receptor homolog AChBP in complex with an alpha-conotoxin PnIA variant.

21 January 2018

1 reference

Phosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor function

21 January 2018

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Comparative protein modelling by satisfaction of spatial restraints

21 January 2018

1 reference

Characterization of a glycine receptor domain that controls the binding and gating mechanisms of the beta-amino acid agonist, taurine

21 January 2018

1 reference

Kinetic and mutational analysis of Zn2+ modulation of recombinant human inhibitory glycine receptors

21 January 2018

1 reference

Zinc coordination sphere in biochemical zinc sites.

21 January 2018

1 reference

Chemical-scale studies on the role of a conserved aspartate in preorganizing the agonist binding site of the nicotinic acetylcholine receptor

21 January 2018

1 reference

Glycine decreases desensitization of N-methyl-D-aspartate (NMDA) receptors expressed in Xenopus oocytes and is required for NMDA responses.

21 January 2018

1 reference

The beta subunit determines the ligand binding properties of synaptic glycine receptors

21 January 2018

1 reference

Redox modulation of GABAA receptors obscured by Zn2+ complexation

21 January 2018

1 reference

Openings of the rat recombinant alpha 1 homomeric glycine receptor as a function of the number of agonist molecules bound

21 January 2018

1 reference

Statistical potential for assessment and prediction of protein structures

21 January 2018

1 reference

Proline-dependent structural and biological properties of peptides and proteins

21 January 2018

1 reference

Coupling of agonist binding to channel gating in the GABA(A) receptor

21 January 2018

1 reference

Principal pathway coupling agonist binding to channel gating in nicotinic receptors

21 January 2018

1 reference

Cis-trans isomerization at a proline opens the pore of a neurotransmitter-gated ion channel.

21 January 2018

1 reference

GABA(A) receptor beta 2 Tyr97 and Leu99 line the GABA-binding site. Insights into mechanisms of agonist and antagonist actions

21 January 2018

1 reference

The role of loop 5 in acetylcholine receptor channel gating.

21 January 2018

1 reference

Mapping the conformational wave of acetylcholine receptor channel gating

21 January 2018

1 reference

Unnatural amino acid mutagenesis of the GABA(A) receptor binding site residues reveals a novel cation-pi interaction between GABA and beta 2Tyr97

21 January 2018

1 reference

Ligand-induced conformational change in the alpha7 nicotinic receptor ligand binding domain

21 January 2018

1 reference

Site-specific fluorescence reveals distinct structural changes with GABA receptor activation and antagonism

21 January 2018

1 reference

Fast events in single-channel currents activated by acetylcholine and its analogues at the frog muscle end-plate

21 January 2018

1 reference

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

21 January 2018

1 reference

Protein structure alignment by incremental combinatorial extension (CE) of the optimal path

21 January 2018

1 reference

UCSF Chimera--a visualization system for exploratory research and analysis

21 January 2018

1 reference

A graph-theory algorithm for rapid protein side-chain prediction

21 January 2018

1 reference

MolProbity: all-atom contacts and structure validation for proteins and nucleic acids

21 January 2018

1 reference

Protein secondary structure prediction based on position-specific scoring matrices

21 January 2018

1 reference

Evolutionarily conserved allosteric network in the Cys loop family of ligand-gated ion channels revealed by statistical covariance analyses

21 January 2018

1 reference

Agonist-driven conformational changes in the inner beta-sheet of alpha7 nicotinic receptors

31 March 2020

1 reference

Asymmetric contribution of the conserved disulfide loop to subunit oligomerization and assembly of the nicotinic acetylcholine receptor.

31 March 2020

1 reference

The energetic ups and downs of protein folding

31 March 2020

1 reference

A novel domain of the inhibitory glycine receptor determining antagonist efficacies: further evidence for partial agonism resulting from self-inhibition

31 March 2020

1 reference

High-Affinity Zinc Inhibition of NMDA NR1–NR2A Receptors

31 March 2020

1 reference

Role of the outer beta-sheet in divalent cation modulation of alpha7 nicotinic receptors

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18806798

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Biphasic modulation of the strychnine-sensitive glycine receptor by Zn2+.

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18806798

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Visualizing secretion and synaptic transmission with pH-sensitive green fluorescent proteins

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18806798

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NSMB.1492

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18806798%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

1 reference

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14 January 2020

PubMed publication ID

18806798

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18806798%20AND%20SRC:MED&resulttype=core&format=json