p53-inducible ribonucleotide reductase (p53R2/RRM2B) is a DNA hypomethylation-independent decitabine gene target that correlates with clinical response in myelodysplastic syndrome/acute myelogenous leukemia (Q39916396)

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English	p53-inducible ribonucleotide reductase (p53R2/RRM2B) is a DNA hypomethylation-independent decitabine gene target that correlates with clinical response in myelodysplastic syndrome/acute myelogenous leukemia	scientific article

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

p53-inducible ribonucleotide reductase (p53R2/RRM2B) is a DNA hypomethylation-independent decitabine gene target that correlates with clinical response in myelodysplastic syndrome/acute myelogenous leukemia (English)

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

1 reference

based on heuristic

inferred from title

4

object named as

David A Jones

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Europe PubMed Central

PMC publication ID

15 September 2017

author name string

Petra A Link

1

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Europe PubMed Central

PMC publication ID

15 September 2017

Maria R Baer

2

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

Smitha R James

3

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

Adam R Karpf

5

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Europe PubMed Central

PMC publication ID

15 September 2017

language of work or name

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publication date

1 November 2008

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Europe PubMed Central

PMC publication ID

15 September 2017

full work available at URL

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2606040

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Cancer Research

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Europe PubMed Central

PMC publication ID

15 September 2017

68

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Europe PubMed Central

PMC publication ID

15 September 2017

22

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

9358-9366

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

Intertumor and intratumor NY-ESO-1 expression heterogeneity is associated with promoter-specific and global DNA methylation status in ovarian cancer

1 reference

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DNA methylation-dependent regulation of BORIS/CTCFL expression in ovarian cancer

1 reference

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DNA methylation inhibitor 5-Aza-2'-deoxycytidine induces reversible genome-wide DNA damage that is distinctly influenced by DNA methyltransferases 1 and 3B.

1 reference

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An ATM- and Rad3-related (ATR) signaling pathway and a phosphorylation-acetylation cascade are involved in activation of p53/p21Waf1/Cip1 in response to 5-aza-2'-deoxycytidine treatment

1 reference

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A potential role for epigenetic modulatory drugs in the enhancement of cancer/germ-line antigen vaccine efficacy

1 reference

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Decitabine and its role in the treatment of hematopoietic malignancies

1 reference

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Epigenomic reactivation screening to identify genes silenced by DNA hypermethylation in human cancer

1 reference

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Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion

1 reference

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p53R2-dependent ribonucleotide reduction provides deoxyribonucleotides in quiescent human fibroblasts in the absence of induced DNA damage.

1 reference

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The epigenomics of cancer

1 reference

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Decitabine--bedside to bench

1 reference

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Results of a randomized study of 3 schedules of low-dose decitabine in higher-risk myelodysplastic syndrome and chronic myelomonocytic leukemia

1 reference

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1 reference

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Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study

1 reference

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Approval summary: azacitidine for treatment of myelodysplastic syndrome subtypes

1 reference

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Specific method for the determination of genomic DNA methylation by liquid chromatography-electrospray ionization tandem mass spectrometry

1 reference

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5-Aza-cytidine is a potent inhibitor of DNA methyltransferase 3a and induces apoptosis in HCT-116 colon cancer cells via Gadd45- and p53-dependent mechanisms

1 reference

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Induction of gene expression by 5-Aza-2'-deoxycytidine in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) but not epithelial cells by DNA-methylation-dependent and -independent mechanisms

1 reference

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Epigenetics in human disease and prospects for epigenetic therapy

1 reference

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Limited gene activation in tumor and normal epithelial cells treated with the DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine

1 reference

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5-aza-2'-deoxycytidine activates the p53/p21Waf1/Cip1 pathway to inhibit cell proliferation.

1 reference

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Epigenetic targets for immune intervention in human malignancies

1 reference

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Reactivating the expression of methylation silenced genes in human cancer

1 reference

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5-Azacytidine and 5-aza-2'-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy

1 reference

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p53R2-dependent pathway for DNA synthesis in a p53-regulated cell cycle checkpoint

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606040

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A ribonucleotide reductase gene is a transcriptional target of p53 and p73

1 reference

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1 reference

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1 reference

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Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands

1 reference

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Toxicity of 5-aza-2'-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation

1 reference

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Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation

1 reference

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25 September 2017

A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy

1 reference

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25 September 2017

Inhibition of DNA methylation by 5-aza-2'-deoxycytidine suppresses the growth of human tumor cell lines

1 reference

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Role of Estrogen Receptor Gene Demethylation and DNA Methyltransferase·DNA Adduct Formation in 5-Aza-2′deoxycytidine-induced Cytotoxicity In Human Breast Cancer Cells

1 reference

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25 September 2017

Mutations of the p53 gene in myelodysplastic syndrome (MDS) and MDS-derived leukemia.

1 reference

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1 reference

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Formation of highly stable complexes between 5-azacytosine-substituted DNA and specific non-histone nuclear proteins. Implications for 5-azacytidine-mediated effects on DNA methylation and gene expression.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606040

17 June 2018

Ribonucleotide reductase small subunit p53R2 facilitates p21 induction of G1 arrest under UV irradiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606040

20 August 2018

Lack of TP53 and FMS gene mutations in children with myelodysplastic syndrome.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606040

20 August 2018

Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606040

20 August 2018

Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2'-deoxycytidine (decitabine) in hematopoietic malignancies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606040

20 August 2018

5-Aza-2'-deoxycytidine (decitabine) treatment of hematopoietic malignancies: a multimechanism therapeutic approach?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606040

20 August 2018

Phase I trial of continuous infusion 5-aza-2'-deoxycytidine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606040

20 August 2018

Demethylation of a hypermethylated P15/INK4B gene in patients with myelodysplastic syndrome by 5-Aza-2'-deoxycytidine (decitabine) treatment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606040

20 August 2018

Activation of the p53 DNA damage response pathway after inhibition of DNA methyltransferase by 5-aza-2'-deoxycytidine.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606040

20 August 2018

Ribonucleotide reductase and mitochondrial DNA synthesis

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606040

1 October 2018

Phase I and pharmacokinetic study of 5-aza-2'-deoxycytidine (NSC 127716) in cancer patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/19010910

12 December 2020

based on heuristic

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Clinical trial on 5-aza-2'-deoxycytidine in patients with acute leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/19010910

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TP53 mutations in myelodysplastic syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/19010910

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical application and proposal for modification of the International Working Group (IWG) response criteria in myelodysplasia

1 reference

https://pubmed.ncbi.nlm.nih.gov/19010910

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1158/0008-5472.CAN-08-1860

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

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