The chemotherapeutic agents XK469 (2-{4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy}propionic acid) and SH80 (2-{4-[(7-bromo-2-quinolinyl)oxy]phenoxy}propionic acid) inhibit cytokinesis and promote polyploidy and induce senescence (Q39907475)

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Language	Label	Description	Also known as
English	The chemotherapeutic agents XK469 (2-{4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy}propionic acid) and SH80 (2-{4-[(7-bromo-2-quinolinyl)oxy]phenoxy}propionic acid) inhibit cytokinesis and promote polyploidy and induce senescence	scientific article

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

The chemotherapeutic agents XK469 (2-{4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy}propionic acid) and SH80 (2-{4-[(7-bromo-2-quinolinyl)oxy]phenoxy}propionic acid) inhibit cytokinesis and promote polyploidy and induce senescence (English)

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

author name string

John J Reiners

1

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

Miriam Kleinman

2

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

Aby Joiakim

3

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

Patricia A Mathieu

4

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

language of work or name

0 references

publication date

9 December 2008

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

Journal of Pharmacology and Experimental Therapeutics

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

328

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

3

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

796-806

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

Suppression of autophagy enhances the cytotoxicity of the DNA-damaging aromatic amine p-anilinoaniline

1 reference

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Use of the novel Plk1 inhibitor ZK-thiazolidinone to elucidate functions of Plk1 in early and late stages of mitosis

1 reference

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How to interpret LC3 immunoblotting

1 reference

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22 September 2017

The role of autophagy in the death of L1210 leukemia cells initiated by the new antitumor agents, XK469 and SH80.

1 reference

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22 September 2017

Autophagy delays apoptotic death in breast cancer cells following DNA damage

1 reference

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DNA damaging agent-induced autophagy produces a cytoprotective adenosine triphosphate surge in malignant glioma cells

1 reference

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Autophagy and antigen presentation

1 reference

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Initiation of apoptosis and autophagy by photodynamic therapy

1 reference

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22 September 2017

BCL2 family of apoptosis-related genes: functions and clinical implications in cancer

1 reference

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Processing and presentation of tumor antigens and vaccination strategies

1 reference

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1 reference

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22 September 2017

Autophagy promotes MHC class II presentation of peptides from intracellular source proteins

1 reference

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22 September 2017

Progress in the discovery of polo-like kinase inhibitors.

1 reference

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22 September 2017

Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682258

22 September 2017

Cell cycle progression after cleavage failure: mammalian somatic cells do not possess a "tetraploidy checkpoint".

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682258

22 September 2017

Dissection of the mammalian midbody proteome reveals conserved cytokinesis mechanisms.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682258

22 September 2017

XK469, a topo IIbeta inhibitor, induces apoptosis in Waldenstrom's macroglobulinemia through multiple pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682258

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Global analysis of protein localization in budding yeast

1 reference

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22 September 2017

Systematic functional analysis of the Caenorhabditis elegans genome using RNAi

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682258

22 September 2017

2-[4-(7-chloro-2-quinoxalinyloxy)phenoxy]-propionic acid (XK469) inhibition of topoisomerase IIbeta is not sufficient for therapeutic response in human Waldenstrom's macroglobulinemia xenograft model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682258

22 September 2017

Molecular regulation of melanocyte senescence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682258

22 September 2017

The human melanocyte: a model system to study the complexity of cellular aging and transformation in non-fibroblastic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682258

22 September 2017

Tetraploid state induces p53-dependent arrest of nontransformed mammalian cells in G1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682258

22 September 2017

Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682258

22 September 2017

XK469, a selective topoisomerase IIbeta poison

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682258

22 September 2017

Suppression of cell cycle progression by flavonoids: dependence on the aryl hydrocarbon receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682258

22 September 2017

Induction of apoptosis by the new anticancer drug XK469 in human ovarian cancer cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682258

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Phorbol ester activation of a proteolytic cascade capable of activating latent transforming growth factor-betaL a process initiated by the exocytosis of cathepsin B.

1 reference

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1 reference

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15 June 2018

Synthetic modification of the 2-oxypropionic acid moiety in 2-{4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy}propionic acid (XK469), and consequent antitumor effects. Part 4.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682258

20 August 2018

Effect of XK469 and adriamycin on the growth of H460 cells in vitro and its mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682258

20 August 2018

Differential susceptibilities of murine hepatoma 1c1c7 and Tao cells to the lysosomal photosensitizer NPe6: influence of aryl hydrocarbon receptor on lysosomal fragility and protease contents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682258

20 August 2018

Mitotic arrest induced by XK469, a novel antitumor agent, is correlated with the inhibition of cyclin B1 ubiquitination

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682258

20 August 2018

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1 reference

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20 August 2018

Design, synthesis, and biological evaluation of analogues of the antitumor agent, 2-(4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy)propionic acid (XK469).

1 reference

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1 reference

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Preclinical antitumor efficacy of analogs of XK469: sodium-(2-[4-(7-chloro-2-quinoxalinyloxy)phenoxy]propionate

1 reference

https://pubmed.ncbi.nlm.nih.gov/19066341

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Melanin accumulation accelerates melanocyte senescence by a mechanism involving p16INK4a/CDK4/pRB and E2F1

1 reference

https://pubmed.ncbi.nlm.nih.gov/19066341

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

XK469, a novel antitumor agent, inhibits signaling by the MEK/MAPK signaling pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/19066341

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1124/JPET.108.144808

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

ResearchGate publication ID

0 references

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