Inhibition of receptor-localized PI3K preserves cardiac beta-adrenergic receptor function and ameliorates pressure overload heart failure (Q39904074)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14523044%20AND%20SRC:MED&resulttype=core&format=json

19 December 2019

title

Inhibition of receptor-localized PI3K preserves cardiac beta-adrenergic receptor function and ameliorates pressure overload heart failure (English)

1 reference

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19 December 2019

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1 reference

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19 December 2019

Jeffrey J Nienaber

1 reference

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19 December 2019

Hideo Tachibana

1 reference

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19 December 2019

Sathyamangla V Naga Prasad

1 reference

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19 December 2019

Dianqing Wu

1 reference

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19 December 2019

Lan Mao

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19 December 2019

Howard A Rockman

1 reference

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19 December 2019

language of work or name

English

0 references

publication date

1 October 2003

1 reference

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19 December 2019

number of pages

1 reference

Journal of Clinical Investigation

inferred from page(s)

published in

1 reference

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19 December 2019

volume

112

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19 December 2019

issue

1 reference

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19 December 2019

page(s)

1067-1079

1 reference

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Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways

19 December 2019

cites work

1 reference

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Phosphoinositide 3-kinase regulates beta2-adrenergic receptor endocytosis by AP-2 recruitment to the receptor/beta-arrestin complex

22 September 2017

1 reference

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Arresting developments in heptahelical receptor signaling and regulation

22 September 2017

1 reference

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beta-Blocker therapy in heart failure: scientific review

22 September 2017

1 reference

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Seven-transmembrane-spanning receptors and heart function

22 September 2017

1 reference

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The interface of receptor trafficking and signalling

22 September 2017

1 reference

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Synthesis and function of 3-phosphorylated inositol lipids

22 September 2017

1 reference

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Cardiac beta ARK1 inhibition prolongs survival and augments beta blocker therapy in a mouse model of severe heart failure

22 September 2017

1 reference

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Rab proteins as membrane organizers

22 September 2017

1 reference

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Gravin-mediated formation of signaling complexes in beta 2-adrenergic receptor desensitization and resensitization

22 September 2017

1 reference

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The conserved phosphoinositide 3-kinase pathway determines heart size in mice

22 September 2017

1 reference

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Beta-adrenergic receptor desensitization in cardiac hypertrophy and heart failure

22 September 2017

1 reference

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Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=198526

Phosphoinositide-AP-2 interactions required for targeting to plasma membrane clathrin-coated pits

22 September 2017

1 reference

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Dynamic complexes of beta2-adrenergic receptors with protein kinases and phosphatases and the role of gravin

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=198526

Cytoskeletal reorganization by G protein-coupled receptors is dependent on phosphoinositide 3-kinase gamma, a Rac guanosine exchange factor, and Rac.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=198526

G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor signaling and desensitization

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=198526

Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=198526

The role of sequestration in G protein-coupled receptor resensitization. Regulation of beta2-adrenergic receptor dephosphorylation by vesicular acidification

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=198526

Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=198526

Agonist-dependent recruitment of phosphoinositide 3-kinase to the membrane by beta-adrenergic receptor kinase 1. A role in receptor sequestration

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=198526

Reciprocal in vivo regulation of myocardial G protein-coupled receptor kinase expression by beta-adrenergic receptor stimulation and blockade

25 September 2017

1 reference

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Mechanism of beta-adrenergic receptor desensitization in cardiac hypertrophy is increased beta-adrenergic receptor kinase

17 June 2018

1 reference

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Tissue-specific regulation of the alpha-myosin heavy chain gene promoter in transgenic mice.

17 June 2018

1 reference

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Phosphatidylinositol 3-kinase functionally compartmentalizes the concurrent G(s) signaling during beta2-adrenergic stimulation

17 June 2018

1 reference

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Beta-adrenergic receptor-mediated DNA synthesis in cardiac fibroblasts is dependent on transactivation of the epidermal growth factor receptor and subsequent activation of extracellular signal-regulated kinases

20 August 2018

1 reference

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Genetic alterations that inhibit in vivo pressure-overload hypertrophy prevent cardiac dysfunction despite increased wall stress.

20 August 2018

1 reference

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G protein-coupled receptor kinases

20 August 2018

1 reference

12 December 2020

Gbetagamma-dependent phosphoinositide 3-kinase activation in hearts with in vivo pressure overload hypertrophy

1 reference

12 December 2020

ACC/AHA Guidelines for the Evaluation and Management of Chronic Heart Failure in the Adult: Executive Summary A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Revise the 1995 Gu

1 reference

12 December 2020

Decreased Catecholamine Sensitivity and β-Adrenergic-Receptor Density in Failing Human Hearts

1 reference

12 December 2020

Plasma norepinephrine as a guide to prognosis in patients with chronic congestive heart failure

1 reference

12 December 2020

Angiotensin II Activates Phosphatidylinositol 3-Kinase in Vascular Smooth Muscle Cells

1 reference

12 December 2020

Defective beta-adrenergic receptor signaling precedes the development of dilated cardiomyopathy in transgenic mice with calsequestrin overexpression

1 reference

12 December 2020

In vivo inhibition of elevated myocardial beta-adrenergic receptor kinase activity in hybrid transgenic mice restores normal beta-adrenergic signaling and function

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI18213

1 reference

15 September 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14523044%20AND%20SRC:MED&resulttype=core&format=json

19 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14523044%20AND%20SRC:MED&resulttype=core&format=json

19 December 2019

PubMed publication ID

14523044

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14523044%20AND%20SRC:MED&resulttype=core&format=json