Targeting human gastrointestinal stromal tumor cells with a quadruplex-binding small molecule. (Q39847153)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19469547%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

title

Targeting human gastrointestinal stromal tumor cells with a quadruplex-binding small molecule (English)

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gastrointestinal stromal tumor

29 January 2020

main subject

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29 January 2020

Mekala Gunaratnam

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29 January 2020

Stephen Swank

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29 January 2020

Katja Galesa

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29 January 2020

Anthony P Reszka

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29 January 2020

Monica Beltran

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29 January 2020

Francisco Cuenca

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29 January 2020

Jonathan A Fletcher

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29 January 2020

Stephen Neidle

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29 January 2020

language of work or name

English

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publication date

1 June 2009

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Journal of Medicinal Chemistry

29 January 2020

published in

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29 January 2020

volume

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29 January 2020

issue

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29 January 2020

page(s)

3774-3783

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Structure of the Human Telomere in K + Solution: A Stable Basket-Type G-Quadruplex with Only Two G-Tetrad Layers

29 January 2020

cites work

1 reference

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Design of selective G-quadruplex ligands as potential anticancer agents

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Genetic aberrations of gastrointestinal stromal tumors

22 September 2017

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Heterogeneity of kinase inhibitor resistance mechanisms in GIST

22 September 2017

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Topology conservation and loop flexibility in quadruplex-drug recognition: crystal structures of inter- and intramolecular telomeric DNA quadruplex-drug complexes

22 September 2017

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TRAP-LIG, a modified telomere repeat amplification protocol assay to quantitate telomerase inhibition by small molecules.

22 September 2017

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Structural basis of DNA quadruplex recognition by an acridine drug

22 September 2017

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Sunitinib: a novel tyrosine kinase inhibitor. A brief review of its therapeutic potential in the treatment of renal carcinoma and gastrointestinal stromal tumors (GIST).

22 September 2017

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A hitchhiker's guide to G-quadruplex ligands

22 September 2017

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Clinical implications of mutational analysis in gastrointestinal stromal tumours

22 September 2017

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Tri- and tetra-substituted naphthalene diimides as potent G-quadruplex ligands.

22 September 2017

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Structure of two intramolecular G-quadruplexes formed by natural human telomere sequences in K+ solution

22 September 2017

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Mechanism of acridine-based telomerase inhibition and telomere shortening

22 September 2017

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Structure of the Hybrid-2 type intramolecular human telomeric G-quadruplex in K+ solution: insights into structure polymorphism of the human telomeric sequence

22 September 2017

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Beyond imatinib: second generation c-KIT inhibitors for the management of gastrointestinal stromal tumors.

22 September 2017

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Structure of an Unprecedented G-Quadruplex Scaffold in the Human c-kit Promoter

22 September 2017

1 reference

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An RNA G-quadruplex in the 5' UTR of the NRAS proto-oncogene modulates translation

22 September 2017

1 reference

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22 September 2017

KIT mutations in GIST.

1 reference

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Molecular correlates of imatinib resistance in gastrointestinal stromal tumors.

22 September 2017

1 reference

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Drug targeting of the c-MYC promoter to repress gene expression via a G-quadruplex silencer element

22 September 2017

1 reference

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Human telomeric sequence forms a hybrid-type intramolecular G-quadruplex structure with mixed parallel/antiparallel strands in potassium solution

22 September 2017

1 reference

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Structure and regulation of Kit protein-tyrosine kinase--the stem cell factor receptor

22 September 2017

1 reference

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The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function.

22 September 2017

1 reference

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PDB2PQR: an automated pipeline for the setup of Poisson-Boltzmann electrostatics calculations

22 September 2017

1 reference

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Telomerase downregulation induced by the G-quadruplex ligand 12459 in A549 cells is mediated by hTERT RNA alternative splicing.

22 September 2017

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Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor

22 September 2017

1 reference

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SU11248 inhibits KIT and platelet-derived growth factor receptor beta in preclinical models of human small cell lung cancer

22 September 2017

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Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription

22 September 2017

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Crystal structure of parallel quadruplexes from human telomeric DNA

22 September 2017

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Electrostatics of nanosystems: application to microtubules and the ribosome

22 September 2017

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Structure-based design of selective and potent G quadruplex-mediated telomerase inhibitors

22 September 2017

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Telomerase inhibitors based on quadruplex ligands selected by a fluorescence assay

22 September 2017

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KIT extracellular and kinase domain mutations in gastrointestinal stromal tumors

22 September 2017

1 reference

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DNA tetraplex formation in the control region of c-myc

22 September 2017

1 reference

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22 September 2017

1 reference

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Characterization of the promoter region of the human c-kit proto-oncogene

22 September 2017

1 reference

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Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand

22 September 2017

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Conventional and molecular cytogenetic characterization of a new human cell line, GIST-T1, established from gastrointestinal stromal tumor

22 September 2017

1 reference

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STI571 inactivation of the gastrointestinal stromal tumor c-KIT oncoprotein: biological and clinical implications

25 September 2017

1 reference

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Sequence occurrence and structural uniqueness of a G-quadruplex in the human c-kit promoter

25 September 2017

1 reference

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Putative DNA quadruplex formation within the human c-kit oncogene

17 June 2018

1 reference

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Trisubstituted isoalloxazines as a new class of G-quadruplex binding ligands: small molecule regulation of c-kit oncogene expression

17 June 2018

1 reference

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A conserved quadruplex motif located in a transcription activation site of the human c-kit oncogene

20 August 2018

1 reference

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Synthesis, biophysical and biological evaluation of 3,6-bis-amidoacridines with extended 9-anilino substituents as potent G-quadruplex-binding telomerase inhibitors.

20 August 2018

1 reference

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Trisubstituted acridine derivatives as potent and selective telomerase inhibitors.

20 August 2018

1 reference

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Inhibition of telomerase limits the growth of human cancer cells.

20 August 2018

1 reference

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Telomerase activity in gastrointestinal stromal tumors

20 August 2018

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12 December 2020

Structure-specific recognition of quadruplex DNA by organic cations: Influence of shape, substituents and charge

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12 December 2020

Sequence and structural selectivity of nucleic acid binding ligands

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12 December 2020

KIT oncoprotein interactions in gastrointestinal stromal tumors: therapeutic relevance

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12 December 2020

Inhibition of myc promoter and telomerase activity and induction of delayed apoptosis by SYUIQ-5, a novel G-quadruplex interactive agent in leukemia cells

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12 December 2020

Identifiers

DOI

10.1021/JM900424A

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19469547%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

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29 January 2020

PubMed publication ID

19469547

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19469547%20AND%20SRC:MED&resulttype=core&format=json