Synthetic cathinone MDPV downregulates glutamate transporter subtype I (GLT-1) and produces rewarding and locomotor-activating effects that are reduced by a GLT-1 activator (Q39845731)

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English	Synthetic cathinone MDPV downregulates glutamate transporter subtype I (GLT-1) and produces rewarding and locomotor-activating effects that are reduced by a GLT-1 activator	scientific article

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scholarly article

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PMC publication ID

15 September 2017

Synthetic cathinone MDPV downregulates glutamate transporter subtype I (GLT-1) and produces rewarding and locomotor-activating effects that are reduced by a GLT-1 activator (English)

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Europe PubMed Central

PMC publication ID

15 September 2017

author name string

Ryan A Gregg

1

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15 September 2017

Callum Hicks

2

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15 September 2017

Sunil U Nayak

3

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15 September 2017

Christopher S Tallarida

4

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15 September 2017

Paul Nucero

5

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15 September 2017

Garry R Smith

6

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15 September 2017

Allen B Reitz

7

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15 September 2017

Scott M Rawls

8

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15 September 2017

publication date

13 April 2016

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15 September 2017

number of pages

9

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Neuropharmacology

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15 September 2017

108

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15 September 2017

111-119

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15 September 2017

Reinforcing and neurochemical effects of the "bath salts" constituents 3,4-methylenedioxypyrovalerone (MDPV) and 3,4-methylenedioxy-N-methylcathinone (methylone) in male rats

1 reference

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Concentrations of MDPV in rat striatum correlate with the psychostimulant effect.

1 reference

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22 September 2017

Stereoselective Actions of Methylenedioxypyrovalerone (MDPV) To Inhibit Dopamine and Norepinephrine Transporters and Facilitate Intracranial Self-Stimulation in Rats

1 reference

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22 September 2017

Binge-like acquisition of 3,4-methylenedioxypyrovalerone (MDPV) self-administration and wheel activity in rats

1 reference

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22 September 2017

Stereochemistry of mephedrone neuropharmacology: enantiomer-specific behavioural and neurochemical effects in rats

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A 3-year review of new psychoactive substances in casework

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Mephedrone, methylone and 3,4-methylenedioxypyrovalerone (MDPV) induce conditioned place preference in mice

1 reference

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Pharmacology of novel synthetic stimulants structurally related to the "bath salts" constituent 3,4-methylenedioxypyrovalerone (MDPV).

1 reference

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Mephedrone interactions with cocaine: prior exposure to the 'bath salt' constituent enhances cocaine-induced locomotor activation in rats

1 reference

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Ceftriaxone attenuates locomotor activity induced by acute and repeated cocaine exposure in mice

1 reference

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Abuse-related and abuse-limiting effects of methcathinone and the synthetic "bath salts" cathinone analogs methylenedioxypyrovalerone (MDPV), methylone and mephedrone on intracranial self-stimulation in rats

1 reference

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Mephedrone (4-methylmethcathinone), a principal constituent of psychoactive bath salts, produces behavioral sensitization in rats

1 reference

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Locomotor stimulant and discriminative stimulus effects of 'bath salt' cathinones

1 reference

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22 September 2017

The novel recreational drug 3,4-methylenedioxypyrovalerone (MDPV) is a potent psychomotor stimulant: self-administration and locomotor activity in rats

1 reference

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22 September 2017

In vivo effects of abused 'bath salt' constituent 3,4-methylenedioxypyrovalerone (MDPV) in mice: drug discrimination, thermoregulation, and locomotor activity

1 reference

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22 September 2017

Powerful cocaine-like actions of 3,4-methylenedioxypyrovalerone (MDPV), a principal constituent of psychoactive 'bath salts' products

1 reference

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22 September 2017

Potent rewarding and reinforcing effects of the synthetic cathinone 3,4-methylenedioxypyrovalerone (MDPV)

1 reference

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22 September 2017

Ceftriaxone upregulates the glutamate transporter in medial prefrontal cortex and blocks reinstatement of methamphetamine seeking in a condition place preference paradigm

1 reference

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22 September 2017

Ceftriaxone prevents the induction of cocaine sensitization and produces enduring attenuation of cue- and cocaine-primed reinstatement of cocaine-seeking

1 reference

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Beta-lactam antibiotic decreases acquisition of and motivation to respond for cocaine, but not sweet food, in C57Bl/6 mice

1 reference

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Glutamate transporter subtype 1 (GLT-1) activator ceftriaxone attenuates amphetamine-induced hyperactivity and behavioral sensitization in rats

1 reference

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22 September 2017

beta-Lactam antibiotic inhibits development of morphine physical dependence in rats

1 reference

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22 September 2017

Ceftriaxone restores glutamate homeostasis and prevents relapse to cocaine seeking

1 reference

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22 September 2017

Upregulation of GLT1 attenuates cue-induced reinstatement of cocaine-seeking behavior in rats

1 reference

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Glutamate and reinstatement

1 reference

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Glutamate transmission in addiction

1 reference

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Up-regulation of GLT1 expression increases glutamate uptake and attenuates the Huntington's disease phenotype in the R6/2 mouse

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Mechanism of ceftriaxone induction of excitatory amino acid transporter-2 expression and glutamate uptake in primary human astrocytes

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Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression.

1 reference

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Roles and regulation of glutamate transporters in the central nervous system

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Alterations in dopaminergic and glutamatergic transmission in the induction and expression of behavioral sensitization: a critical review of preclinical studies

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Sex differences in 3,4-methylenedioxypyrovalerone (MDPV)-induced taste avoidance and place preferences.

1 reference

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An assessment of MDPV-induced place preference in adult Sprague-Dawley rats

1 reference

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1 reference

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Neuroadaptations in cystine-glutamate exchange underlie cocaine relapse

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Prefrontal glutamate release into the core of the nucleus accumbens mediates cocaine-induced reinstatement of drug-seeking behavior.

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Repeated Cocaine Administration Alters Extracellular Glutamate in the Ventral Tegmental Area

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Synthesis and GC-MS analysis of a series of homologs and regioisomers of 3,4-methylenedioxypyrovalerone (MDPV)

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12 December 2020

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Identifiers

10.1016/J.NEUROPHARM.2016.04.014

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

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