Parkin protects mitochondrial genome integrity and supports mitochondrial DNA repair (Q39823278)

14 September 2017

title

Parkin protects mitochondrial genome integrity and supports mitochondrial DNA repair (English)

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14 September 2017

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Thomas Gasser

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14 September 2017

Daniela Berg

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14 September 2017

ORCID Public Data File 2021

Manu Sharma

object named as

Manu Sharma

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14 September 2017

Oliver Rothfuss

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14 September 2017

Heike Fischer

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14 September 2017

Takafumi Hasegawa

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14 September 2017

Martina Maisel

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14 September 2017

Petra Leitner

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14 September 2017

Franziska Miesel

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14 September 2017

Antje Bornemann

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14 September 2017

Nadja Patenge

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14 September 2017

publication date

19 July 2009

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14 September 2017

published in

Human Molecular Genetics

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14 September 2017

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14 September 2017

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14 September 2017

page(s)

3832-3850

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Epidemiology of Parkinson's disease

14 September 2017

cites work

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Chronic systemic pesticide exposure reproduces features of Parkinson's disease

21 January 2018

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Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis

21 January 2018

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High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease

21 January 2018

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Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP327

PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP327

DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP327

Mitochondrial complex I and IV activities in leukocytes from patients with parkin mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP327

Mitochondrial dysfunction and oxidative damage in parkin-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP327

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP327

Biochemical analysis of Parkinson's disease-causing variants of Parkin, an E3 ubiquitin-protein ligase with monoubiquitylation capacity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP327

Alpha-synuclein and parkin contribute to the assembly of ubiquitin lysine 63-linked multiubiquitin chains

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP327

Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDP327

21 January 2018

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Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP327

Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP327

Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP327

Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP327

Parkin enhances mitochondrial biogenesis in proliferating cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP327

The mitochondrial transcription factor TFAM coordinates the assembly of multiple DNA molecules into nucleoid-like structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP327

Human mitochondrial DNA is packaged with TFAM.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP327

Sequential treatment of SH-SY5Y cells with retinoic acid and brain-derived neurotrophic factor gives rise to fully differentiated, neurotrophic factor-dependent, human neuron-like cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP327

The PINK1-Parkin pathway is involved in the regulation of mitochondrial remodeling process.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP327

Mitochondrial function and morphology are impaired in parkin-mutant fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP327

The PINK1/Parkin pathway regulates mitochondrial morphology

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP327

Parkin protects human dopaminergic neuroblastoma cells against dopamine-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP327

Contribution of mitochondrial DNA repair to cell resistance from oxidative stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP327

Reactive oxygen species regulate DNA copy number in isolated yeast mitochondria by triggering recombination-mediated replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP327

Parkin mediates the degradation-independent ubiquitination of Hsp70

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP327

Parkin is associated with cellular vesicles

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP327

Immunohistochemical and subcellular localization of Parkin protein: absence of protein in autosomal recessive juvenile parkinsonism patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP327

Immunodetection of Parkin protein in vertebrate and invertebrate brains: a comparative study using specific antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP327

Ultrastructural localization of parkin in the rat brainstem, thalamus and basal ganglia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP327

A mitochondrial protein compendium elucidates complex I disease biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP327

Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP327

Functions and dysfunctions of mitochondrial dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP327

Mitochondrial alterations in Parkinson's disease: new clues

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP327

6-Hydroxydopamine (6-OHDA) induces Drp1-dependent mitochondrial fragmentation in SH-SY5Y cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP327

Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP327

Oxidative stress-induced apoptosis in neurons correlates with mitochondrial DNA base excision repair pathway imbalance

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP327

Mitochondrial DNA repair: a critical player in the response of cells of the CNS to genotoxic insults

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP327

Mitochondrial DNA, base excision repair and neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP327

Different organization of base excision repair of uracil in DNA in nuclei and mitochondria and selective upregulation of mitochondrial uracil-DNA glycosylase after oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP327

Parkin protects against mitochondrial toxins and beta-amyloid accumulation in skeletal muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP327

Regulation of DNA repair by parkin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP327

Influence of mitochondrial DNA level on cellular energy metabolism: implications for mitochondrial diseases

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDP327

Number matters: control of mammalian mitochondrial DNA copy number

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDP327

Longitudinal increases in mitochondrial DNA levels in blood cells are associated with survival in critically ill patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP327

Mitochondrial DNA content: its genetic heritability and association with renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP327

Parkin-induced mitophagy in the pathogenesis of Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP327

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP327

Progressive parkinsonism in mice with respiratory-chain-deficient dopamine neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP327

Increased dopamine and its metabolites in SH‐SY5Y neuroblastoma cells that express tyrosinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP327

Identification of unknown target genes of human transcription factors using chromatin immunoprecipitation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP327

Parkin protects against tyrosinase-mediated dopamine neurotoxicity by suppressing stress-activated protein kinase pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP327

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP327

Accelerated alpha-synuclein aggregation after differentiation of SH-SY5Y neuroblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP327

PINK1 controls mitochondrial localization of Parkin through direct phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP327

Improved methods to isolate and subfractionate rat liver mitochondria. Lipid composition of the inner and outer membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP327

Cyclin-dependent kinase 5 is an upstream regulator of mitochondrial fission during neuronal apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP327

21 January 2018

Identifiers

DOI

10.1093/HMG/DDP327

1 reference

14 September 2017

1 reference