Mice deficient for the chromosome 21 ortholog Itsn1 exhibit vesicle-trafficking abnormalities. (Q39752644)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18676989%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

title

Mice deficient for the chromosome 21 ortholog Itsn1 exhibit vesicle-trafficking abnormalities (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18676989%20AND%20SRC:MED&resulttype=core&format=json

Intersectin 1 (SH3 domain protein 1A)

11 January 2020

main subject

1 reference

GOA release 2020-03-11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18676989%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18676989%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18676989%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

Yong Yu

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18676989%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

Po-Yin Chu

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18676989%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

Damien J Keating

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18676989%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

Daphne Dubach

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18676989%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

Josephine Tkalcevic

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18676989%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

Melanie A Pritchard

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18676989%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

publication date

2 August 2008

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18676989%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

published in

Human Molecular Genetics

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18676989%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

volume

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18676989%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

issue

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18676989%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

page(s)

3281-3290

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18676989%20AND%20SRC:MED&resulttype=core&format=json

The pathological association between Down syndrome and Alzheimer disease

11 January 2020

cites work

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN224

Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN224

Endosome function and dysfunction in Alzheimer's disease and other neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN224

Rab5-stimulated up-regulation of the endocytic pathway increases intracellular beta-cleaved amyloid precursor protein carboxyl-terminal fragment levels and Abeta production

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN224

Alu-splice cloning of human Intersectin (ITSN), a putative multivalent binding protein expressed in proliferating and differentiating neurons and overexpressed in Down syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN224

Proteins regulating Ras and its relatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN224

The pleckstrin homology domain: an intriguing multifunctional protein module

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN224

Intersectin, a novel adaptor protein with two Eps15 homology and five Src homology 3 domains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN224

Splice variants of intersectin are components of the endocytic machinery in neurons and nonneuronal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN224

The EH and SH3 domain Ese proteins regulate endocytosis by linking to dynamin and Eps15.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN224

Intersectin activates Ras but stimulates transcription through an independent pathway involving JNK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN224

The endocytic protein intersectin is a major binding partner for the Ras exchange factor mSos1 in rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN224

Intersectin can regulate the Ras/MAP kinase pathway independent of its role in endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN224

Endocytic protein intersectin-l regulates actin assembly via Cdc42 and N-WASP

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN224

Intersectin regulates epidermal growth factor receptor endocytosis, ubiquitylation, and signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN224

Regulation of neuron survival through an intersectin-phosphoinositide 3'-kinase C2beta-AKT pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN224

Intersectin-1L nucleotide exchange factor regulates secretory granule exocytosis by activating Cdc42

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN224

Dap160/intersectin acts as a stabilizing scaffold required for synaptic development and vesicle endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN224

Dap160/intersectin scaffolds the periactive zone to achieve high-fidelity endocytosis and normal synaptic growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN224

Neuronal distribution of EHSH1/intersectin: molecular linker between clathrin-mediated endocytosis and signaling pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN224

Three modes of synaptic vesicular recycling revealed by single-vesicle imaging

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN224

Clathrin-mediated endocytosis is the dominant mechanism of vesicle retrieval at hippocampal synapses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN224

Nerve growth factor signaling, neuroprotection, and neural repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN224

Failed retrograde transport of NGF in a mouse model of Down's syndrome: reversal of cholinergic neurodegenerative phenotypes following NGF infusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN224

Decreased synaptic vesicle recycling efficiency and cognitive deficits in amphiphysin 1 knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN224

Synaptic vesicle alterations in rod photoreceptors of synaptophysin-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN224

Mouse models of Down syndrome: how useful can they be? Comparison of the gene content of human chromosome 21 with orthologous mouse genomic regions

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN224

DSCR1/RCAN1 regulates vesicle exocytosis and fusion pore kinetics: implications for Down syndrome and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN224

Alzheimer's disease and endocytic dysfunction: clues from the Down syndrome-related proteins, DSCR1 and ITSN1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN224

NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN224

Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN224

The dual phosphatase activity of synaptojanin1 is required for both efficient synaptic vesicle endocytosis and reavailability at nerve terminals

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN224

Delay in vesicle fusion revealed by electrochemical monitoring of single secretory events in adrenal chromaffin cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN224

Visualizing secretion and synaptic transmission with pH-sensitive green fluorescent proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN224

Two forms of single-vesicle astrocyte exocytosis imaged with total internal reflection fluorescence microscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN224

Intersectin-1s Regulates the Mitochondrial Apoptotic Pathway in Endothelial Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN224