Neuroblastoma phox2b variants stimulate proliferation and dedifferentiation of immature sympathetic neurons (Q39749759)

20089899

14 September 2017

title

Neuroblastoma phox2b variants stimulate proliferation and dedifferentiation of immature sympathetic neurons (English)

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14 September 2017

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15 May 2020

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15 May 2020

Mirko Schmidt

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15 May 2020

author name string

Konstantina Tsarovina

series ordinal

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15 May 2020

Afsaneh Majdazari

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Hermann Rohrer

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15 May 2020

language of work or name

English

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publication date

1 January 2010

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20089899

14 September 2017

published in

Journal of Neuroscience

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volume

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issue

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page(s)

905-915

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15 May 2020

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cites work

The homeobox gene Phox2b is essential for the development of autonomic neural crest derivatives

1 reference

12 December 2020

Paired-like homeodomain proteins Phox2a/Arix and Phox2b/NBPhox have similar genetic organization and independently regulate dopamine beta-hydroxylase gene transcription

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12 December 2020

Characterization of homo- and heterodimerization of cardiac Csx/Nkx2.5 homeoprotein

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The Phox2b transcription factor coordinately regulates neuronal cell cycle exit and identity

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p27Kip1 and p57Kip2 regulate proliferation in distinct retinal progenitor cell populations.

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Modulation of basic helix-loop-helix transcription complex formation by Id proteins during neuronal differentiation

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Two genetic hits (more or less) to cancer

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The paired-like homeodomain protein, Arix, mediates protein kinase A-stimulated dopamine beta-hydroxylase gene transcription through its phosphorylation status

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Specification of catecholaminergic and serotonergic neurons.

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The role of Phox2b in synchronizing pan-neuronal and type-specific aspects of neurogenesis.

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Molecular control of ciliary neuron development: BMPs and downstream transcriptional control in the parasympathetic lineage

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Neuroblastoma: biological insights into a clinical enigma

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Polyalanine expansion and frameshift mutations of the paired-like homeobox gene PHOX2B in congenital central hypoventilation syndrome

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PMX2B, a new candidate gene for Hirschsprung's disease.

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12 December 2020

The Interaction between dHAND and Arix at the Dopamine β-Hydroxylase Promoter Region Is Independent of Direct dHAND Binding to DNA

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12 December 2020

HAND2 synergistically enhances transcription of dopamine-beta-hydroxylase in the presence of Phox2a.

1 reference

12 December 2020

Idiopathic congenital central hypoventilation syndrome: Analysis of genes pertinent to early autonomic nervous system embryologic development and identification of mutations in PHOX2b

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Phox2b controls the development of peripheral chemoreceptors and afferent visceral pathways.

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Germline mutations of the paired-like homeobox 2B (PHOX2B) gene in neuroblastoma

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Haploinsufficiency for Phox2b in mice causes dilated pupils and atrophy of the ciliary ganglion: mechanistic insights into human congenital central hypoventilation syndrome.

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Germline PHOX2B mutation in hereditary neuroblastoma

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The Phox2B homeobox gene is mutated in sporadic neuroblastomas

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Mechanisms and perspectives on differentiation of autonomic neurons

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PHOX2B genotype allows for prediction of tumor risk in congenital central hypoventilation syndrome

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Germline mutations of the paired-like homeobox 2B (PHOX2B) gene in neuroblastoma

1 reference

12 December 2020

PHOX2B regulates its own expression by a transcriptional auto-regulatory mechanism

1 reference

12 December 2020

Molecular consequences of PHOX2B missense, frameshift and alanine expansion mutations leading to autonomic dysfunction

1 reference

12 December 2020

Reciprocal gene replacements reveal unique functions for Phox2 genes during neural differentiation.

1 reference

12 December 2020

The TLX2 homeobox gene is a transcriptional target of PHOX2B in neural-crest-derived cells

1 reference

12 December 2020

PHOX2B analysis in non-syndromic neuroblastoma cases shows novel mutations and genotype-phenotype associations.

1 reference

12 December 2020

Neuroblastoma as an experimental model for neuronal differentiation and hypoxia-induced tumor cell dedifferentiation

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12 December 2020

The sympathoadrenal cell lineage: specification, diversification, and new perspectives

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12 December 2020

Homeodomain transcription factor Phox2a, via cyclic AMP-mediated activation, induces p27Kip1 transcription, coordinating neural progenitor cell cycle exit and differentiation

1 reference

12 December 2020

A cell-autonomous requirement for Cip/Kip cyclin-kinase inhibitors in regulating neuronal cell cycle exit but not differentiation in the developing spinal cord

1 reference

12 December 2020

Embryonic sympathoblasts transiently express TrkB in vivo and proliferate in response to brain-derived neurotrophic factor in vitro

1 reference

12 December 2020

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12 December 2020

Prevalence and functional consequence of PHOX2B mutations in neuroblastoma.

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12 December 2020

Progenitor cell maintenance and neurogenesis in sympathetic ganglia involves Notch signaling

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12 December 2020

Conditional deletion of Hand2 reveals critical functions in neurogenesis and cell type-specific gene expression for development of neural crest-derived noradrenergic sympathetic ganglion neurons

1 reference

12 December 2020

Identification of ALK as a major familial neuroblastoma predisposition gene

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Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma

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Oncogenic mutations of ALK kinase in neuroblastoma

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Activating mutations in ALK provide a therapeutic target in neuroblastoma

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In Vitro studies of non poly alanine PHOX2B mutations argue against a loss-of-function mechanism for congenital central hypoventilation

1 reference

12 December 2020

The bHLH transcription factor Hand2 is essential for the maintenance of noradrenergic properties in differentiated sympathetic neurons

1 reference

12 December 2020

Relationship between differentiation and terminal mitosis: chick sensory and ciliary neurons differentiate after terminal mitosis of precursor cells, whereas sympathetic neurons continue to divide after differentiation.

1 reference

12 December 2020

Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage

1 reference

12 December 2020

Evidence for an important role of IGF-I and IGF-II for the early development of chick sympathetic neurons

1 reference

12 December 2020

Expression and function of TRK-B and BDNF in human neuroblastomas

1 reference

12 December 2020

Association between high levels of expression of the TRK gene and favorable outcome in human neuroblastoma

1 reference

12 December 2020

Coexpression of messenger RNA for TRK protooncogene and low affinity nerve growth factor receptor in neuroblastoma with favorable prognosis

1 reference

12 December 2020

A homeodomain protein selectively expressed in noradrenergic tissue regulates transcription of neurotransmitter biosynthetic genes

1 reference

12 December 2020

Paired-like homeodomain proteins, Phox2a and Phox2b, are responsible for noradrenergic cell-specific transcription of the dopamine beta-hydroxylase gene

1 reference

12 December 2020

Regulation of neurotrophin receptor expression by retinoic acid in mouse sympathetic neuroblasts.

1 reference

12 December 2020

10.1523/JNEUROSCI.5368-09.2010

Identifiers

DOI

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15 May 2020

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15 May 2020

20089899

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6633096&resulttype=core&format=json