A functional human Poly(A) site requires only a potent DSE and an A-rich upstream sequence. (Q39722557)

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29 January 2020

title

A functional human Poly(A) site requires only a potent DSE and an A-rich upstream sequence (English)

1 reference

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29 January 2020

1 reference

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29 January 2020

Nuno Miguel Nunes

1 reference

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29 January 2020

Wencheng Li

series ordinal

1 reference

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29 January 2020

André Furger

series ordinal

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29 January 2020

language of work or name

English

0 references

publication date

25 March 2010

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29 January 2020

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29 January 2020

volume

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29 January 2020

issue

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29 January 2020

page(s)

1523-1536

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A family of splice variants of CstF-64 expressed in vertebrate nervous systems

29 January 2020

cites work

1 reference

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Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing

14 September 2017

1 reference

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Alternative isoform regulation in human tissue transcriptomes

14 September 2017

1 reference

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Phylogenetic analysis of mRNA polyadenylation sites reveals a role of transposable elements in evolution of the 3'-end of genes

14 September 2017

1 reference

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Messenger RNA 3' end formation in plants.

14 September 2017

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3' end mRNA processing: molecular mechanisms and implications for health and disease

14 September 2017

1 reference

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The 3' processing factor CstF functions in the DNA repair response

14 September 2017

1 reference

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Loss of polyadenylation protein tauCstF-64 causes spermatogenic defects and male infertility.

14 September 2017

1 reference

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The poly(A)-dependent transcriptional pause is mediated by CPSF acting on the body of the polymerase

14 September 2017

1 reference

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Systematic variation in mRNA 3'-processing signals during mouse spermatogenesis

14 September 2017

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Differences in polyadenylation site choice between somatic and male germ cells

14 September 2017

1 reference

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An interaction between U2AF 65 and CF I(m) links the splicing and 3' end processing machineries

14 September 2017

1 reference

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DNA damage-induced BARD1 phosphorylation is critical for the inhibition of messenger RNA processing by BRCA1/BARD1 complex

14 September 2017

1 reference

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Pre-messenger RNA processing and its regulation: a genomic perspective

14 September 2017

1 reference

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Elevated levels of the 64-kDa cleavage stimulatory factor (CstF-64) in lipopolysaccharide-stimulated macrophages influence gene expression and induce alternative poly(A) site selection

14 September 2017

1 reference

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Analysis of a noncanonical poly(A) site reveals a tripartite mechanism for vertebrate poly(A) site recognition

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876958

Pre-mRNA processing enhancer (PPE) elements from intronless genes play additional roles in mRNA biogenesis than do ones from intron-containing genes

14 September 2017

1 reference

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A large-scale analysis of mRNA polyadenylation of human and mouse genes

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876958

New perspectives on connecting messenger RNA 3' end formation to transcription

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876958

Recognition of GU-rich polyadenylation regulatory elements by human CstF-64 protein

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876958

Downstream elements of mammalian pre-mRNA polyadenylation signals: primary, secondary and higher-order structures.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876958

Integrating mRNA processing with transcription

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876958

The BARD1-CstF-50 interaction links mRNA 3' end formation to DNA damage and tumor suppression

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876958

hnRNP F influences binding of a 64-kilodalton subunit of cleavage stimulation factor to mRNA precursors in mouse B cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876958

Patterns of variant polyadenylation signal usage in human genes

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876958

Recruitment of a basal polyadenylation factor by the upstream sequence element of the human lamin B2 polyadenylation signal.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876958

Two distinct forms of the 64,000 Mr protein of the cleavage stimulation factor are expressed in mouse male germ cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876958

Formation of mRNA 3' ends in eukaryotes: mechanism, regulation, and interrelationships with other steps in mRNA synthesis

14 September 2017

1 reference

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Levels of polyadenylation factor CstF-64 control IgM heavy chain mRNA accumulation and other events associated with B cell differentiation

14 September 2017

1 reference

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The mouse histone H2a gene contains a small element that facilitates cytoplasmic accumulation of intronless gene transcripts and of unspliced HIV-1-related mRNAs

14 September 2017

1 reference

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Targeted disruption of the melanocortin-4 receptor results in obesity in mice

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876958

The polyadenylation factor CstF-64 regulates alternative processing of IgM heavy chain pre-mRNA during B cell differentiation

14 September 2017

1 reference

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Functional analysis of point mutations in the AAUAAA motif of the SV40 late polyadenylation signal

14 September 2017

1 reference

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Point mutations in AAUAAA and the poly (A) addition site: effects on the accuracy and efficiency of cleavage and polyadenylation in vitro

14 September 2017

1 reference

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Two G-rich regulatory elements located adjacent to and 440 nucleotides downstream of the core poly(A) site of the intronless melanocortin receptor 1 gene are critical for efficient 3' end processing

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876958

Transgenic mice expressing green fluorescent protein under the control of the melanocortin-4 receptor promoter.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876958

The carboxyl terminus of vertebrate poly(A) polymerase interacts with U2AF 65 to couple 3'-end processing and splicing

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876958

U1A inhibits cleavage at the immunoglobulin M heavy-chain secretory poly(A) site by binding between the two downstream GU-rich regions

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876958

Upstream sequence elements enhance poly(A) site efficiency of the C2 complement gene and are phylogenetically conserved

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876958

3'-end-forming signals of yeast mRNA.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876958

Analysis of mRNA 3' end formation by modification interference: the only modifications which prevent processing lie in AAUAAA and the poly(A) site

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876958

Molecular architecture of the human pre-mRNA 3' processing complex

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876958

A Kaposi's sarcoma virus RNA element that increases the nuclear abundance of intronless transcripts

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876958

A novel function for the U2AF 65 splicing factor in promoting pre-mRNA 3'-end processing.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876958

Multiple transcripts of the murine immunoglobulin epsilon membrane locus are generated by alternative splicing and differential usage of two polyadenylation sites

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876958

A 64 kd nuclear protein binds to RNA segments that include the AAUAAA polyadenylation motif

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876958

Identification of mRNA polyadenylation sites in genomes using cDNA sequences, expressed sequence tags, and Trace.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876958

PolyA_DB 2: mRNA polyadenylation sites in vertebrate genes

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876958

Direct interactions between subunits of CPSF and the U2 snRNP contribute to the coupling of pre-mRNA 3' end processing and splicing.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876958

The RNA tether from the poly(A) signal to the polymerase mediates coupling of transcription to cleavage and polyadenylation

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876958

Bioinformatic identification of candidate cis-regulatory elements involved in human mRNA polyadenylation

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876958

Upstream elements present in the 3'-untranslated region of collagen genes influence the processing efficiency of overlapping polyadenylation signals

20 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20339349

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Role of the Conserved AAUAAA Sequence: Four AAUAAA Point Mutants Prevent Messenger RNA 3′ End Formation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20339349

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/EMBOJ.2010.42

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20339349%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20339349%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

PubMed publication ID

20339349

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20339349%20AND%20SRC:MED&resulttype=core&format=json