HepaRG human hepatic cell line utility as a surrogate for primary human hepatocytes in drug metabolism assessment in vitro (Q39705178)

14 September 2017

title

HepaRG human hepatic cell line utility as a surrogate for primary human hepatocytes in drug metabolism assessment in vitro (English)

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14 September 2017

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Katrin Zeilinger

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14 September 2017

Marc Lübberstedt

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14 September 2017

Ursula Müller-Vieira

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14 September 2017

Manuela Mayer

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14 September 2017

Klaus M Biemel

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14 September 2017

Fanny Knöspel

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14 September 2017

Daniel Knobeloch

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14 September 2017

Andreas K Nüssler

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14 September 2017

Jörg C Gerlach

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14 September 2017

publication date

9 May 2010

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Journal of Pharmacological and Toxicological Methods

14 September 2017

published in

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14 September 2017

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14 September 2017

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14 September 2017

page(s)

59-68

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Cryopreservation of adult human hepatocytes obtained from resected liver biopsies

14 September 2017

cites work

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.04.013

Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.04.013

Isolation, culture and characterization of adult human hepatocytes from surgical liver biopsies

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.04.013

Use of heterologously expressed human cytochrome P4501A2 to predict tacrine-fluvoxamine drug interaction in man

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.04.013

Cultured human adult hepatocytes: a new model for drug metabolism studies

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.04.013

Contribution of amine oxidases to the metabolism of xenobiotics

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.04.013

An update on in vitro test methods in human hepatic drug biotransformation research: pros and cons

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.04.013

Transdifferentiation of hepatocyte-like cells from the human hepatoma HepaRG cell line through bipotent progenitor.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.04.013

Drug interaction between oral atorvastatin and verapamil in healthy subjects: effects of atorvastatin on the pharmacokinetics of verapamil and norverapamil

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.04.013

Strategies and molecular probes to investigate the role of cytochrome P450 in drug metabolism: focus on in vitro studies.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.04.013

Time-dependent expression of cytochrome P450 genes in primary cultures of well-differentiated human hepatocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.04.013

Expression and induction of a large set of drug-metabolizing enzymes by the highly differentiated human hepatoma cell line BC2.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.04.013

Infection of a human hepatoma cell line by hepatitis B virus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.04.013

The human hepatoma HepaRG cells: a highly differentiated model for studies of liver metabolism and toxicity of xenobiotics

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.04.013

Use of human hepatocyte cultures for drug metabolism studies

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.04.013

Effect of voriconazole on the pharmacokinetics of diclofenac

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.04.013

Evaluation of the effects of hydrophilic organic solvents on CYP3A-mediated drug-drug interaction in vitro

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.04.013

Aldehyde oxidase-catalysed oxidation of methotrexate in the liver of guinea-pig, rabbit and man.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.04.013

Long-term functional stability of human HepaRG hepatocytes and use for chronic toxicity and genotoxicity studies.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.04.013

Evaluation of HepaRG cells as an in vitro model for human drug metabolism studies

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.04.013

HepaRG cells as an in vitro model for evaluation of cytochrome P450 induction in humans

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.04.013

Analysis of plasma protein and lipoprotein synthesis in long-term primary cultures of baboon hepatocytes maintained in serum-free medium

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.04.013

Species-specific toxicity of diclofenac and troglitazone in primary human and rat hepatocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.04.013

Metabolic and non-metabolic factors determining troglitazone hepatotoxicity: a review

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.04.013

Expression of the human aryl hydrocarbon receptor complex in yeast. Activation of transcription by indole compounds

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.04.013

Contributions of five human cytochrome P450 isoforms to the N-demethylation of clozapine in vitro at low and high concentrations

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.04.013

Pathways of carbamazepine bioactivation in vitro. III. The role of human cytochrome P450 enzymes in the formation of 2,3-dihydroxycarbamazepine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.04.013

Expression and induction potential of cytochromes P450 in human cryopreserved hepatocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.04.013

Induction of cytochrome-P450 in cryopreserved rat and human hepatocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.04.013

Mechanisms of troglitazone hepatotoxicity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.04.013

Effects of troglitazone on HepG2 viability and mitochondrial function

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.04.013

Multiple human cytochromes contribute to biotransformation of dextromethorphan in-vitro: role of CYP2C9, CYP2C19, CYP2D6, and CYP3A

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.04.013

10.1016/J.VASCN.2010.04.013

7 January 2021

Identifiers

DOI

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14 September 2017

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