An xrcc4 defect or Wortmannin stimulates homologous recombination specifically induced by double-strand breaks in mammalian cells. (Q39686977)

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11 November 2019

title

An xrcc4 defect or Wortmannin stimulates homologous recombination specifically induced by double-strand breaks in mammalian cells (English)

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11 November 2019

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11 November 2019

Fabien Delacôte

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11 November 2019

Mingguang Han

series ordinal

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11 November 2019

Thomas D Stamato

series ordinal

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11 November 2019

Maria Jasin

series ordinal

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11 November 2019

language of work or name

English

0 references

publication date

1 August 2002

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11 November 2019

published in

Nucleic Acids Research

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11 November 2019

volume

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11 November 2019

issue

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11 November 2019

page(s)

3454-3463

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Mutations of Bacteria from Virus Sensitivity to Virus Resistance

11 November 2019

cites work

1 reference

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DNA-dependent protein kinase suppresses double-strand break-induced and spontaneous homologous recombination

14 September 2017

1 reference

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Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells

14 September 2017

1 reference

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Characterization of homologous recombination induced by replication inhibition in mammalian cells

14 September 2017

1 reference

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A novel role for the Bcl-2 protein family: specific suppression of the RAD51 recombination pathway

14 September 2017

1 reference

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Genetic evidence for the involvement of DNA ligase IV in the DNA-PK-dependent pathway of non-homologous end joining in mammalian cells

14 September 2017

1 reference

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Wortmannin potentiates integrase-mediated killing of lymphocytes and reduces the efficiency of stable transduction by retroviruses.

14 September 2017

1 reference

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Deficient DNA end joining activity in extracts from fanconi anemia fibroblasts

14 September 2017

1 reference

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Coupled homologous and nonhomologous repair of a double-strand break preserves genomic integrity in mammalian cells

14 September 2017

1 reference

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Homologous and non-homologous recombination differentially affect DNA damage repair in mice

14 September 2017

1 reference

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Replication fork pausing and recombination or "gimme a break"

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137076

Mammalian XRCC2 promotes the repair of DNA double-strand breaks by homologous recombination

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137076

The DNA-dependent protein kinase

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137076

Absence of DNA ligase IV protein in XR-1 cells: evidence for stabilization by XRCC4.

14 September 2017

1 reference

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DNA end-joining catalyzed by human cell-free extracts

14 September 2017

1 reference

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Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137076

Homology-directed repair is a major double-strand break repair pathway in mammalian cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137076

The XRCC4 gene product is a target for and interacts with the DNA-dependent protein kinase

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137076

Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137076

Identification of a Saccharomyces cerevisiae Ku80 homologue: roles in DNA double strand break rejoining and in telomeric maintenance

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137076

Saccharomyces cerevisiae Ku70 potentiates illegitimate DNA double-strand break repair and serves as a barrier to error-prone DNA repair pathways

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137076

DNA strand annealing is promoted by the yeast Rad52 protein

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137076

Genetic requirements for the single-strand annealing pathway of double-strand break repair in Saccharomyces cerevisiae

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137076

Ku80-deficient cells exhibit excess degradation of extrachromosomal DNA.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137076

Cell cycle-dependent expression of the mouse Rad51 gene in proliferating cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137076

Nuclear foci of mammalian Rad51 recombination protein in somatic cells after DNA damage and its localization in synaptonemal complexes

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137076

DNA-dependent protein kinase activity is absent in xrs-6 cells: implications for site-specific recombination and DNA double-strand break repair

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137076

Carcinogens can induce homologous recombination between duplicated chromosomal sequences in mouse L cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137076

Sister chromatid gene conversion is a prominent double-strand break repair pathway in mammalian cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137076

Characterization of mammalian RAD51 double strand break repair using non-lethal dominant-negative forms.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137076

Two alternative pathways of double-strand break repair that are kinetically separable and independently modulated

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137076

Mutant p53 proteins stimulate spontaneous and radiation-induced intrachromosomal homologous recombination independently of the alteration of the transactivation activity and of the G1 checkpoint.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137076

Binding of double-strand breaks in DNA by human Rad52 protein

25 September 2017

1 reference

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Menage à trois: double strand break repair, V(D)J recombination and DNA-PK.

25 September 2017

1 reference

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Radiosensitization of human tumor cells by the phosphatidylinositol3-kinase inhibitors wortmannin and LY294002 correlates with inhibition of DNA-dependent protein kinase and prolonged G2-M delay

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137076

Expression of the human RAD51 gene during the cell cycle in primary human peripheral blood lymphocytes.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137076

Requirement for an interaction of XRCC4 with DNA ligase IV for wild-type V(D)J recombination and DNA double-strand break repair in vivo.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137076

The Saccharomyces cerevisiae Ku autoantigen homologue affects radiosensitivity only in the absence of homologous recombination

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137076

High spontaneous intrachromosomal recombination rates in ataxia-telangiectasia

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137076

Cell cycle-dependent protein expression of mammalian homologs of yeast DNA double-strand break repair genes Rad51 and Rad52

15 June 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/12140331

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Wortmannin is a potent inhibitor of DNA double strand break but not single strand break repair in Chinese hamster ovary cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/12140331

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Cleavage and phosphorylation of XRCC4 protein induced by X-irradiation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/12140331

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/NAR/GKF452

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12140331%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12140331%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

PubMed publication ID

12140331

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12140331%20AND%20SRC:MED&resulttype=core&format=json