Insertional mutagenesis identifies multiple networks of cooperating genes driving intestinal tumorigenesis (Q39677519)

13 September 2017

Insertional mutagenesis identifies multiple networks of cooperating genes driving intestinal tumorigenesis (English)

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13 September 2017

Jeroen de Ridder

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Alistair G Rust

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Nicholas A Wright

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H Nikki March

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13 September 2017

Jelle ten Hoeve

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13 September 2017

Matthew Eldridge

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13 September 2017

Louise van der Weyden

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13 September 2017

Anton Berns

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13 September 2017

Jules Gadiot

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13 September 2017

Anthony Uren

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13 September 2017

Richard Kemp

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13 September 2017

Mark J Arends

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13 September 2017

Lodewyk F A Wessels

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13 September 2017

Douglas J Winton

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13 September 2017

David J Adams

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13 September 2017

language of work or name

English

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publication date

6 November 2011

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13 September 2017

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13 September 2017

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13 September 2017

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13 September 2017

1202-1209

1 reference

describes a project that uses

13 September 2017

Cytoscape

1 reference

9 June 2022

https://europepmc.org/search?query=(METHODS:'Cytoscape')

based on heuristic

inferred from PubMed Central ID database lookup

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14 September 2017

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Stat3 is a negative regulator of intestinal tumor progression in Apc(Min) mice

14 September 2017

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14 September 2017

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14 September 2017

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14 September 2017

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Comprehensive proteome analysis of an Apc mouse model uncovers proteins associated with intestinal tumorigenesis.

14 September 2017

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A conditional transposon-based insertional mutagenesis screen for genes associated with mouse hepatocellular carcinoma.

14 September 2017

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Loss of Rb1 in the gastrointestinal tract of Apc1638N mice promotes tumors of the cecum and proximal colon.

14 September 2017

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CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity

14 September 2017

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14 September 2017

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Large-scale mutagenesis in p19(ARF)- and p53-deficient mice identifies cancer genes and their collaborative networks

14 September 2017

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14 September 2017

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Genetic progression and the waiting time to cancer

14 September 2017

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Oncogenic transformation and experimental models of human cancer

14 September 2017

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The genetics of hereditary colon cancer

14 September 2017

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The genomic landscapes of human breast and colorectal cancers

14 September 2017

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Aneuploidy arises at early stages of Apc-driven intestinal tumorigenesis and pinpoints conserved chromosomal loci of allelic imbalance between mouse and human

14 September 2017

1 reference

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Detecting statistically significant common insertion sites in retroviral insertional mutagenesis screens

14 September 2017

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Colorectal cancer and genetic alterations in the Wnt pathway

14 September 2017

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Cross-talk of WNT and FGF signaling pathways at GSK3beta to regulate beta-catenin and SNAIL signaling cascades

14 September 2017

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Hopping around the tumor genome: transposons for cancer gene discovery

14 September 2017

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Spontaneous mutations in diploid Saccharomyces cerevisiae: more beneficial than expected

14 September 2017

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Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of beta-catenin

14 September 2017

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Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer

14 September 2017

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APC mutations in sporadic colorectal carcinomas from The Netherlands Cohort Study

14 September 2017

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The Wnt antagonist sFRP1 in colorectal tumorigenesis

14 September 2017

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14 September 2017

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Lessons from hereditary colorectal cancer

14 September 2017

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Genetic alterations during colorectal-tumor development

14 September 2017

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A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse

14 September 2017

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Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene

14 September 2017

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The receptor tyrosine kinase EPHB4 has tumor suppressor activities in intestinal tumorigenesis.

14 September 2017

1 reference

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Intestinal adenoma formation and MYC activation are regulated by cooperation between MYB and Wnt signaling.

14 September 2017

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A high-throughput splinkerette-PCR method for the isolation and sequencing of retroviral insertion sites

14 September 2017

1 reference

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APC and the three-hit hypothesis

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233530

Heterozygous disruption of the PTEN promotes intestinal neoplasia in APCmin/+ mouse: roles of osteopontin

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233530

APC and oncogenic KRAS are synergistic in enhancing Wnt signaling in intestinal tumor formation and progression

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233530

ERK activation drives intestinal tumorigenesis in Apc(min/+) mice

14 September 2017

1 reference

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Cancer gene discovery in solid tumours using transposon-based somatic mutagenesis in the mouse

25 September 2017

1 reference

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Detection of high incidence of K-ras oncogenes during human colon tumorigenesis

17 June 2018

1 reference

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Prevalence of TMPRSS2-ERG fusion prostate cancer among men undergoing prostate biopsy in the United States

17 June 2018

1 reference

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Paneth cell differentiation in colonic epithelial neoplasms: evidence for the role of the Apc/beta-catenin/Tcf pathway.

21 August 2018

1 reference

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The Apc 1322T mouse develops severe polyposis associated with submaximal nuclear beta-catenin expression.

21 August 2018

1 reference

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Variants on 9p24 and 8q24 are associated with risk of colorectal cancer: results from the Colon Cancer Family Registry

21 August 2018

1 reference

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Smad3 deficiency promotes tumorigenesis in the distal colon of ApcMin/+ mice.

21 August 2018

1 reference

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Intestinal-specific PPARgamma deficiency enhances tumorigenesis in ApcMin/+ mice.

21 August 2018

1 reference

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Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system.

21 August 2018

1 reference

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Transcriptional profiling of the transition from normal intestinal epithelia to adenomas and carcinomas in the APCMin/+ mouse

21 August 2018

1 reference

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Rapid Colorectal Adenoma Formation Initiated by Conditional Targeting of the Apc Gene

21 August 2018

1 reference

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TRANSFAC retrieval program: a network model database of eukaryotic transcription regulating sequences and proteins

21 August 2018

1 reference

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On the nature of susceptibility to cancer. The presidential address

21 August 2018

1 reference

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Selection, the mutation rate and cancer: Ensuring that the tail does not wag the dog

21 August 2018

1 reference

COSMIC (the Catalogue of Somatic Mutations in Cancer): a resource to investigate acquired mutations in human cancer

21 January 2018

1 reference

Deletion of the WNT Target and Cancer Stem Cell Marker CD44 in Apc(Min/+) Mice Attenuates Intestinal Tumorigenesis

21 January 2018

1 reference

Prevalence of ras gene mutations in human colorectal cancers

21 January 2018

1 reference

Dysregulation of intestinal crypt cell proliferation and villus cell migration in mice lacking Kruppel-like factor 9

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22057237

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NG.990

1 reference

Dimensions Publication ID

13 September 2017

0 references

1 reference

13 September 2017

PubMed publication ID

22057237

1 reference