The Caspase Inhibitor IDN-6556 Attenuates Hepatic Injury and Fibrosis in the Bile Duct Ligated Mouse (Q39669200)

13 September 2017

title

The caspase inhibitor IDN-6556 attenuates hepatic injury and fibrosis in the bile duct ligated mouse (English)

1 reference

13 September 2017

The Caspase Inhibitor IDN-6556 Attenuates Hepatic Injury and Fibrosis in the Bile Duct Ligated Mouse (English)

1 reference

Crossref

DOI

https://api.crossref.org/works/10.1124/JPET.103.060129

2 April 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14617689

2 April 2024

1 reference

https://api.crossref.org/works/10.1124/JPET.103.060129

2 April 2024

1 reference

https://api.crossref.org/works/10.1124/JPET.103.060129

2 April 2024

Gregory J Gores

1 reference

13 September 2017

Ali Canbay

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14617689

2 April 2024

Ariel Feldstein

1 reference

13 September 2017

Edwina Baskin-Bey

series ordinal

1 reference

13 September 2017

Steven F. Bronk

series ordinal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14617689

2 April 2024

language of work or name

English

0 references

publication date

14 November 2003

1 reference

full work available at URL

13 September 2017

https://syndication.highwire.org/content/doi/10.1124/jpet.103.060129

1 reference

Crossref

DOI

https://api.crossref.org/works/10.1124/JPET.103.060129

Journal of Pharmacology and Experimental Therapeutics

2 April 2024

published in

1 reference

13 September 2017

volume

308

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13 September 2017

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13 September 2017

page(s)

1191-1196

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Lethal effect of the anti-Fas antibody in mice

13 September 2017

cites work

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Kupffer cell engulfment of apoptotic bodies stimulates death ligand and cytokine expression

2 April 2024

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Cathepsin B inactivation attenuates hepatic injury and fibrosis during cholestasis

2 April 2024

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Fas enhances fibrogenesis in the bile duct ligated mouse: a link between apoptosis and fibrosis.

2 April 2024

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Regulation of the proinflammatory effects of Fas ligand (CD95L).

2 April 2024

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Anti-Fas induces hepatic chemokines and promotes inflammation by an NF-kappa B-independent, caspase-3-dependent pathway

2 April 2024

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Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury

2 April 2024

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The role of the macrophage in apoptosis: hunter, gatherer, and regulator

2 April 2024

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Neutrophils aggravate acute liver injury during obstructive cholestasis in bile duct-ligated mice

2 April 2024

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The biochemistry of apoptosis

2 April 2024

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Cholestasis increases tumor necrosis factor-related apoptotis-inducing ligand (TRAIL)-R2/DR5 expression and sensitizes the liver to TRAIL-mediated cytotoxicity

2 April 2024

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2 April 2024

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Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors

2 April 2024

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Apoptosis of hepatic stellate cells: involvement in resolution of biliary fibrosis and regulation by soluble growth factors

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Inflammation in response to hepatocellular apoptosis

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2 April 2024

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2 April 2024

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2 April 2024

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Parenchymal cell apoptosis as a signal for sinusoidal sequestration and transendothelial migration of neutrophils in murine models of endotoxin and Fas-antibody-induced liver injury

2 April 2024

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Chemokines--chemotactic cytokines that mediate inflammation

2 April 2024

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Interactions between hepatic stellate cells and the immune system

2 April 2024

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Adenovirus-mediated expression of cytokine-induced neutrophil chemoattractant in rat liver induces a neutrophilic hepatitis

2 April 2024

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Caspase 1-independent IL-1β release and inflammation induced by the apoptosis inducer Fas ligand

2 April 2024

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Hepatocyte apoptosis after bile duct ligation in the mouse involves Fas.

2 April 2024

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The caspase inhibitor IDN-6556 prevents caspase activation and apoptosis in sinusoidal endothelial cells during liver preservation injury

2 April 2024

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Hepatocyte apoptosis is a pathologic feature of human alcoholic hepatitis

2 April 2024

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Mechanisms of caspase activation and inhibition during apoptosis

2 April 2024

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RNA interference targeting Fas protects mice from fulminant hepatitis

2 April 2024

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Caspases: key mediators of apoptosis

2 April 2024

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2 April 2024

Caspases: enemies within

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First clinical trial of a novel caspase inhibitor: anti-apoptotic caspase inhibitor, IDN-6556, improves liver enzymes.

2 April 2024

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Death receptor-mediated apoptosis and the liver

2 April 2024

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2 April 2024

Identifiers

DOI

1 reference

13 September 2017

1 reference