Inhibition of p53 induces invasion of serous borderline ovarian tumor cells by accentuating PI3K/Akt-mediated suppression of E-cadherin (Q39640387)

13 September 2017

title

Inhibition of p53 induces invasion of serous borderline ovarian tumor cells by accentuating PI3K/Akt-mediated suppression of E-cadherin (English)

1 reference

13 September 2017

J-C Cheng

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20972462

9 August 2024

P. C K. Leung

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20972462

9 August 2024

N. Auersperg

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20972462

9 August 2024

language of work or name

English

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publication date

25 October 2010

1 reference

full work available at URL

13 September 2017

https://www.nature.com/articles/onc2010486.pdf

file format

Portable Document Format

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https://api.crossref.org/works/10.1038/ONC.2010.486

https://www.nature.com/articles/onc2010486

9 August 2024

1 reference

https://api.crossref.org/works/10.1038/ONC.2010.486

9 August 2024

1 reference

13 September 2017

1 reference

13 September 2017

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13 September 2017

page(s)

1020-1031

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Rb depletion results in deregulation of E-cadherin and induction of cellular phenotypic changes that are characteristic of the epithelial-to-mesenchymal transition.

13 September 2017

cites work

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Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness

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The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors

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Expression profiling of serous low malignant potential, low-grade, and high-grade tumors of the ovary.

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The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression

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Expression of cadherins in benign, borderline, and malignant ovarian epithelial tumors: A clinicopathologic study of 60 cases

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Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis.

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PI3K/Akt signalling pathway and cancer.

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Enumeration of the simian virus 40 early region elements necessary for human cell transformation

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Molecular requirements for epithelial-mesenchymal transition during tumor progression

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Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 3' kinase/AKT pathways

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The epithelial-mesenchymal transition: new insights in signaling, development, and disease

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Inactivation of the mitogen-activated protein kinase pathway as a potential target-based therapy in ovarian serous tumors with KRAS or BRAF mutations

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Gain of oncogenic function of p53 mutants regulates E-cadherin expression uncoupled from cell invasion in colon cancer cells

21 January 2018

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Phosphatidylinositol 3-kinases in tumor progression

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High frequency of mutations of the PIK3CA gene in human cancers

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TP53 and ovarian cancer

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PIK3CA is implicated as an oncogene in ovarian cancer.

21 January 2018

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Molecular pathogenesis of ovarian borderline tumors: new insights and old challenges

21 January 2018

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Patterns of p53 mutations separate ovarian serous borderline tumors and low- and high-grade carcinomas and provide support for a new model of ovarian carcinogenesis: a mutational analysis with immunohistochemical correlation.

21 January 2018

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AKT1/PKBalpha kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells

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Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role

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p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug

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An improved assay to quantitate the invasiveness of cells in modified Boyden chambers

21 January 2018

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SV40 early genes induce neoplastic properties in serous borderline ovarian tumor cells.

21 January 2018

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Serous borderline ovarian tumors in long-term culture: phenotypic and genotypic distinction from invasive ovarian carcinomas.

21 January 2018

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Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis

21 January 2018

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NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription

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Mutation of the PIK3CA gene in ovarian and breast cancer

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Serous borderline tumors of the ovary with noninvasive peritoneal implants

31 March 2020

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Mutations of BRAF and KRAS precede the development of ovarian serous borderline tumors

31 March 2020

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Early recurrence of ovarian serous borderline tumor as high-grade carcinoma: a report of two cases

31 March 2020

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Differential expression of the cell-cell adhesion molecule E-cadherin in ascites and solid human ovarian tumor cells

31 March 2020

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31 March 2020

1198

W Birchmeier

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Analysis of p53-regulated gene expression patterns using oligonucleotide arrays

9 August 2024

1 reference

https://api.crossref.org/works/10.1038/ONC.2010.486

9 August 2024

Identifiers

DOI

10.1038/ONC.2010.486

1 reference

13 September 2017

1 reference