Characterization of drug resistance-associated mutations in the human cytomegalovirus DNA polymerase gene by using recombinant mutant viruses generated from overlapping DNA fragments (Q39582502)

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scientific article published on July 1998

Language	Label	Description	Also known as
English	Characterization of drug resistance-associated mutations in the human cytomegalovirus DNA polymerase gene by using recombinant mutant viruses generated from overlapping DNA fragments	scientific article published on July 1998

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

Characterization of drug resistance-associated mutations in the human cytomegalovirus DNA polymerase gene by using recombinant mutant viruses generated from overlapping DNA fragments (English)

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

Cytomegalovirus

0 references

author name string

T Cihlar

1

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

M D Fuller

2

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

J M Cherrington

3

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

language of work or name

0 references

publication date

1 July 1998

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

Journal of Virology

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

72

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

7

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

5927-5936

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

In vitro characterization of the anti-human cytomegalovirus activity of PMEA (Adefovir)

1 reference

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Lobucavir is phosphorylated in human cytomegalovirus-infected and -uninfected cells and inhibits the viral DNA polymerase

1 reference

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Effect of incorporation of cidofovir into DNA by human cytomegalovirus DNA polymerase on DNA elongation

1 reference

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In vitro expression of the human cytomegalovirus DNA polymerase gene: effects of sequence alterations on enzyme activity

1 reference

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A point mutation in the human cytomegalovirus DNA polymerase gene confers resistance to ganciclovir and phosphonylmethoxyalkyl derivatives

1 reference

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Mutations in human cytomegalovirus UL97 gene confer clinical resistance to ganciclovir and can be detected directly in patient plasma

1 reference

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Potential mechanism for sustained antiretroviral efficacy of AZT-3TC combination therapy

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Human DNA polymerase alpha gene expression is cell proliferation dependent and its primary structure is similar to both prokaryotic and eukaryotic replicative DNA polymerases

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Antiviral effects of phosphonoformate (PFA, foscarnet sodium).

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Impact of cytomegalovirus infection on organ transplant recipients

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Herpes simplex virus-specified DNA polymerase is the target for the antiviral action of 9-(2-phosphonylmethoxyethyl)adenine

1 reference

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Foscarnet. A review of its antiviral activity, pharmacokinetic properties and therapeutic use in immunocompromised patients with cytomegalovirus retinitis

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A protein kinase homologue controls phosphorylation of ganciclovir in human cytomegalovirus-infected cells

1 reference

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Defined large-scale alterations of the human cytomegalovirus genome constructed by cotransfection of overlapping cosmids

1 reference

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Single amino acid changes in the DNA polymerase confer foscarnet resistance and slow-growth phenotype, while mutations in the UL97-encoded phosphotransferase confer ganciclovir resistance in three double-resistant human cytomegalovirus strains recov

1 reference

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Open reading frames UL44, IRS1/TRS1, and UL36-38 are required for transient complementation of human cytomegalovirus oriLyt-dependent DNA synthesis.

1 reference

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Eleven loci encoding trans-acting factors are required for transient complementation of human cytomegalovirus oriLyt-dependent DNA replication.

1 reference

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Mutation in the UL97 open reading frame of human cytomegalovirus strains resistant to ganciclovir.

1 reference

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A three-nucleotide deletion in the UL97 open reading frame is responsible for the ganciclovir resistance of a human cytomegalovirus clinical isolate

1 reference

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Point mutations in the DNA polymerase gene of human cytomegalovirus that result in resistance to antiviral agents

1 reference

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Boundaries and structure of human cytomegalovirus oriLyt, a complex origin for lytic-phase DNA replication

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A point mutation within a distinct conserved region of the herpes simplex virus DNA polymerase gene confers drug resistance

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"The end of innocence" revisited: resistance of herpesviruses to antiviral drugs

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Identification of enzymes catalyzing two-step phosphorylation of cidofovir and the effect of cytomegalovirus infection on their activities in host cells

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Cidofovir: a new therapy for cytomegalovirus retinitis

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Double resistance to ganciclovir and foscarnet of four human cytomegalovirus strains recovered from AIDS patients

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Related functional domains in virus DNA polymerases

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In vitro antiviral susceptibilities of isolates from cytomegalovirus retinitis patients receiving first- or second-line cidofovir therapy: relationship to clinical outcome.

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Expression of the Catalytic Subunit (UL54) and the Accessory Protein (UL44) of Human Cytomegalovirus DNA Polymerase in a Coupledin VitroTranscription/Translation System

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High-level resistance of cytomegalovirus to ganciclovir is associated with alterations in both the UL97 and DNA polymerase genes

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A general structure for DNA-dependent DNA polymerases.

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Primary structure of the catalytic subunit of calf thymus DNA polymerase .delta.: sequence similarities with other DNA polymerases

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Human cytomegalovirus UL97 open reading frame encodes a protein that phosphorylates the antiviral nucleoside analogue ganciclovir

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Cytomegalovirus retinitis after initiation of highly active antiretroviral therapy

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Four dually resistant human cytomegalovirus strains from AIDS patients: single mutations in UL97 and UL54 open reading frames are responsible for ganciclovir- and foscarnet-specific resistance, respectively.

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Analysis of the UL97 phosphotransferase coding sequence in clinical cytomegalovirus isolates and identification of mutations conferring ganciclovir resistance.

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Progressive disease due to ganciclovir-resistant cytomegalovirus in immunocompromised patients

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Evolution of Mutations Conferring Multidrug Resistance during Prophylaxis and Therapy for Cytomegalovirus Disease

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Susceptibility of human cytomegalovirus to cidofovir is unchanged after limited in vivo exposure to various regimens of drug

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https://pubmed.ncbi.nlm.nih.gov/9621055

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Antiviral susceptibilities and analysis of UL97 and DNA polymerase sequences of clinical cytomegalovirus isolates from immunocompromised patients

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https://pubmed.ncbi.nlm.nih.gov/9621055

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Cytomegalovirus (CMV) culture results, drug resistance, and clinical outcome in patients with AIDS and CMV retinitis treated with foscarnet or ganciclovir. Studies of Ocular Complications of AIDS (SOCA) in collaboration with the AIDS Clinical Trial

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Acute cytomegalovirus infection in AIDS patients with CD4 counts above 100 x 10(6) cells/l following combination antiretroviral therapy including protease inhibitors

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inferred from PubMed ID database lookup

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PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

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