Blocking LFA-1 activation with lovastatin prevents graft-versus-host disease in mouse bone marrow transplantation. (Q39559416)

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11 February 2020

title

Blocking LFA-1 activation with lovastatin prevents graft-versus-host disease in mouse bone marrow transplantation (English)

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11 February 2020

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11 February 2020

Richard E Champlin

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11 February 2020

Yang Wang

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11 February 2020

Dan Li

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11 February 2020

Dan Jones

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11 February 2020

Roland Bassett

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11 February 2020

George E Sale

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11 February 2020

Jahan Khalili

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11 February 2020

Daniel R Couriel

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11 February 2020

Jeffrey J Molldrem

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11 February 2020

Qing Ma

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11 February 2020

publication date

7 October 2009

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Biology of Blood and Marrow Transplantation

11 February 2020

published in

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11 February 2020

volume

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11 February 2020

issue

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11 February 2020

page(s)

1513-1522

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Efalizumab discontinuation: a practical strategy

11 February 2020

cites work

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Preemptive HMG-CoA reductase inhibition provides graft-versus-host disease protection by Th-2 polarization while sparing graft-versus-leukemia activity

14 September 2017

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14 September 2017

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In vivo analyses of early events in acute graft-versus-host disease reveal sequential infiltration of T-cell subsets

14 September 2017

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How T cells use LFA-1 to attach and migrate

14 September 2017

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Integrin avidity regulation: are changes in affinity and conformation underemphasized?

14 September 2017

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Statins as anti-inflammatory agents

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Conformational regulation of integrin structure and function

14 September 2017

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Locking a leukocyte integrin with statins

14 September 2017

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Reversibly locking a protein fold in an active conformation with a disulfide bond: integrin alphaL I domains with high affinity and antagonist activity in vivo

14 September 2017

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Locking in alternate conformations of the integrin alphaLbeta2 I domain with disulfide bonds reveals functional relationships among integrin domains

14 September 2017

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Relative contribution of LFA-1 and Mac-1 to neutrophil adhesion and migration

14 September 2017

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Lymphocyte migration in lymphocyte function-associated antigen (LFA)-1-deficient mice

14 September 2017

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Leukocyte adhesion--structure and function of human leukocyte beta2-integrins and their cellular ligands

14 September 2017

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LFA-1-deficient mice show normal CTL responses to virus but fail to reject immunogenic tumor

14 September 2017

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Lymphocyte homing and homeostasis

14 September 2017

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Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm

14 September 2017

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The dynamic regulation of integrin adhesiveness

14 September 2017

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Activation-induced conformational changes in the I domain region of lymphocyte function-associated antigen 1.

14 September 2017

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Model of the alphaLbeta2 integrin I-domain/ICAM-1 DI interface suggests that subtle changes in loop orientation determine ligand specificity

25 September 2017

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Generation of an LFA-1 antagonist by the transfer of the ICAM-1 immunoregulatory epitope to a small molecule

15 June 2018

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Recent advances in graft‐versus‐host disease (GVHD) prevention

15 June 2018

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LFA-1 affinity regulation is necessary for the activation and proliferation of naive T cells

15 June 2018

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A prospective trial to evaluate the safety and efficacy of pravastatin for the treatment of refractory chronic graft-versus-host disease

21 August 2018

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Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site

21 August 2018

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Coblockade of the LFA1:ICAM and CD28/CTLA4:B7 pathways is a highly effective means of preventing acute lethal graft-versus-host disease induced by fully major histocompatibility complex-disparate donor grafts

21 August 2018

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Reduction in the severity of graft-versus-host disease and increased survival in allogenic mice by treatment with monoclonal antibodies to cell adhesion antigens LFA-1 alpha and MALA-2

4 November 2018

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12 December 2020

A novel targeted T-cell modulator, efalizumab, for plaque psoriasis

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12 December 2020

The physiological disposition of lovastatin

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12 December 2020

Effective treatment of experimental lupus nephritis by combined administration of anti-CD11a and anti-CD54 antibodies

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12 December 2020

Efficiency of antibodies directed against adhesion molecules to prolong skin graft survival in mice

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12 December 2020

LFA-1 (CD11a) as a therapeutic target

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12 December 2020

Structural biology. Changing partners

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12 December 2020

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Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19896074%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

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11 February 2020

PubMed publication ID

19896074

1 reference

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