LLL12 inhibits endogenous and exogenous interleukin-6-induced STAT3 phosphorylation in human pancreatic cancer cells (Q39510992)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21737619%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

title

LLL12 inhibits endogenous and exogenous interleukin-6-induced STAT3 phosphorylation in human pancreatic cancer cells (English)

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7 February 2020

1 reference

1 reference

Aiguo Liu

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7 February 2020

Yan Liu

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7 February 2020

Pui-Kai Li

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7 February 2020

Chenglong Li

1 reference

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7 February 2020

Jiayuh Lin

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7 February 2020

language of work or name

English

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publication date

1 June 2011

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7 February 2020

June 2011

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National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21737619

full work available at URL

6 December 2024

https://europepmc.org/articles/PMC4288000

1 reference

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https://europepmc.org/articles/PMC4288000?pdf=render

6 December 2024

file format

Portable Document Format

online access status

open access

content deliverer

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6 December 2024

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7 February 2020

volume

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7 February 2020

issue

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7 February 2020

page(s)

2029-2035

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Expression of Concern: A small molecule, LLL12 inhibits constitutive STAT3 and IL‐6‐induced STAT3 signaling and exhibits potent growth suppressive activity in human multiple myeloma cells

7 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4288000

Targeted Inhibition of Src Kinase Signaling Attenuates Pancreatic Tumorigenesis

12 September 2017

1 reference

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12 September 2017

Cancer statistics, 2010

1 reference

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Novel STAT3 phosphorylation inhibitors exhibit potent growth-suppressive activity in pancreatic and breast cancer cells

12 September 2017

1 reference

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Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression

12 September 2017

1 reference

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A novel small molecule, LLL12, inhibits STAT3 phosphorylation and activities and exhibits potent growth-suppressive activity in human cancer cells

12 September 2017

1 reference

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Autocrine IL-6 signaling: a key event in tumorigenesis?

12 September 2017

1 reference

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IL-6 involvement in epithelial cancers

12 September 2017

1 reference

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STAT3 as a central mediator of neoplastic cellular transformation

12 September 2017

1 reference

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The role of IL-6 and STAT3 in inflammation and cancer

12 September 2017

1 reference

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The STATs of cancer--new molecular targets come of age

12 September 2017

1 reference

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Targeted anti-interleukin-6 monoclonal antibody therapy for cancer: a review of the rationale and clinical evidence.

12 September 2017

1 reference

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Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway

12 September 2017

1 reference

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Effects of IL-6 and AG490 on regulation of Stat3 signaling pathway and invasion of human pancreatic cancer cells in vitro

12 September 2017

1 reference

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Role of RAF/MEK/ERK pathway, p-STAT-3 and Mcl-1 in sorafenib activity in human pancreatic cancer cell lines

14 September 2017

1 reference

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Interleukin-6 dependent survival of multiple myeloma cells involves the Stat3-mediated induction of microRNA-21 through a highly conserved enhancer

14 September 2017

1 reference

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Inflammation, HCC and sex: IL-6 in the centre of the triangle

14 September 2017

1 reference

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IL-6 is required for glioma development in a mouse model

21 August 2018

1 reference

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Activated signal transducer and activator of transcription 3 (STAT3) supports the malignant phenotype of human pancreatic cancer.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4288000

Elevated serum interleukin-6 levels in patients with pancreatic cancer

21 August 2018

1 reference

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Clinical Significance of Interleukin-6 (Il-6) Gene Polymorphism and Il-6 Serum Level in Pancreatic Adenocarcinoma and Chronic Pancreatitis

21 August 2018

1 reference

12 December 2020

Relationship of serum levels of interleukin-6, soluble interleukin-6 receptor and tumour necrosis factor receptors to the acute-phase protein response in advanced pancreatic cancer

1 reference

12 December 2020

Cytokines in pancreatic carcinoma: correlation with phenotypic characteristics and prognosis

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12 December 2020

A new small-molecule Stat3 inhibitor

1 reference

12 December 2020

Identifiers

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21737619%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

1 reference

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