SNX-2112, a novel Hsp90 inhibitor, induces G2/M cell cycle arrest and apoptosis in MCF-7 cells (Q39493984)

12 September 2017

title

SNX-2112, a novel Hsp90 inhibitor, induces G2/M cell cycle arrest and apoptosis in MCF-7 cells (English)

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12 September 2017

Shao-Xiang Wang

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12 September 2017

Huai-Qiang Ju

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12 September 2017

Kai-Sheng Liu

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12 September 2017

Jia-Xuan Zhang

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12 September 2017

Xiao Wang

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12 September 2017

Yang-Fei Xiang

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12 September 2017

Rui Wang

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12 September 2017

Jin-Yun Liu

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12 September 2017

Qiu-Ying Liu

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12 September 2017

Min Xia

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12 September 2017

Guo-Wen Xing

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12 September 2017

Zhong Liu

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12 September 2017

Yi-Fei Wang

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12 September 2017

publication date

7 August 2011

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Bioscience, Biotechnology, and Biochemistry

12 September 2017

published in

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12 September 2017

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12 September 2017

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12 September 2017

page(s)

1540-1545

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Structure and mechanism of the Hsp90 molecular chaperone machinery

12 September 2017

cites work

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Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the hsp90 chaperone

21 January 2018

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Discovery and development of Hsp90 inhibitors: a promising pathway for cancer therapy

21 January 2018

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Transcriptomic and proteomic approach to studying SNX-2112-induced K562 cells apoptosis and anti-leukemia activity in K562-NOD/SCID mice

21 January 2018

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SNX2112, a synthetic heat shock protein 90 inhibitor, has potent antitumor activity against HER kinase-dependent cancers

21 January 2018

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Targeting of multiple signaling pathways by the Hsp90 inhibitor SNX-2112 in EGFR resistance models as a single agent or in combination with erlotinib

21 January 2018

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Discovery of benzamide tetrahydro-4H-carbazol-4-ones as novel small molecule inhibitors of Hsp90

21 January 2018

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Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

21 January 2018

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The p53-dependent apoptotic pathway of breast cancer cells (BC-M1) induced by the bis-type bioreductive compound aziridinylnaphthoquinone

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21 January 2018

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Drug interactions and cytotoxic effects of paclitaxel in combination with carboplatin, epirubicin, gemcitabine or vinorelbine in breast cancer cell lines and tumor samples

21 January 2018

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SNX-2112, a selective Hsp90 inhibitor, potently inhibits tumor cell growth, angiogenesis, and osteoclastogenesis in multiple myeloma and other hematologic tumors by abrogating signaling via Akt and ERK

21 January 2018

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Hsp90 inhibitors cause G2/M arrest associated with the reduction of Cdc25C and Cdc2 in lung cancer cell lines

21 January 2018

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Disruption of cell cycle kinetics by benzo[a]pyrene: inverse expression patterns of BRCA-1 and p53 in MCF-7 cells arrested in S and G2.

21 January 2018

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Cell death regulation by the Bcl-2 protein family in the mitochondria

21 January 2018

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Enhanced tumor cell radiosensitivity and abrogation of G2 and S phase arrest by the Hsp90 inhibitor 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin

21 January 2018

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Antiproliferative and apoptotic activities of tosylcyclonovobiocic acids as potent heat shock protein 90 inhibitors in human cancer cells

21 January 2018

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A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells

21 January 2018

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Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene

21 January 2018

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Multipathway model enables prediction of kinase inhibitor cross-talk effects on migration of Her2-overexpressing mammary epithelial cells

21 January 2018

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The Akt/PKB pathway: molecular target for cancer drug discovery

21 January 2018

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Overexpression of Ras, Raf and L-myc but not Bcl-2 family proteins is linked with resistance to TCR-mediated apoptosis and tumorigenesis in thymic lymphomas from TCR transgenic mice.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1271/BBB.110225

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release_nnzps4roobf6hff5nbt6bznbbe

12 September 2017

Fatcat ID

0 references

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