Authentically phosphorylated α-synuclein at Ser129 accelerates neurodegeneration in a rat model of familial Parkinson's disease. (Q39441767)

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English	Authentically phosphorylated α-synuclein at Ser129 accelerates neurodegeneration in a rat model of familial Parkinson's disease.	scientific article

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6633319

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title

Authentically phosphorylated α-synuclein at Ser129 accelerates neurodegeneration in a rat model of familial Parkinson's disease (English)

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6633319

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main subject

phosphorylation

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Parkinson's disease

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Synuclein

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neurodegeneration

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author name string

Hiroyasu Sato

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1

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6633319

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Shigeki Arawaka

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2

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6633319

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Susumu Hara

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3

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6633319

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Shingo Fukushima

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4

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6633319

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Kaori Koga

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5

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6633319

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Shingo Koyama

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6

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Takeo Kato

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7

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language of work or name

English

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publication date

1 November 2011

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6633319

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published in

Journal of Neuroscience

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6633319

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volume

31

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6633319

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issue

46

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6633319

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16884-16894

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ImageJ

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11 June 2022

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cites work

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Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein

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Synucleins are a novel class of substrates for G protein-coupled receptor kinases

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Clinical and pathological features of a Parkinsonian syndrome in a family with an Ala53Thr alpha-synuclein mutation

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Vesicle permeabilization by protofibrillar alpha-synuclein: implications for the pathogenesis and treatment of Parkinson's disease

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alpha-Synuclein is phosphorylated in synucleinopathy lesions

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Endogenous G protein-coupled receptor kinase 6 Regulates M3 muscarinic acetylcholine receptor phosphorylation and desensitization in human SH-SY5Y neuroblastoma cells

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Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal system.

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Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease

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12 December 2020

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Concurrence of alpha-synuclein and tau brain pathology in the Contursi kindred

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PubMed

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12 December 2020

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Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice

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Production and purification of serotype 1, 2, and 5 recombinant adeno-associated viral vectors

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Promoters and regulatory elements that improve adeno-associated virus transgene expression in the brain

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Ubiquitination of alpha-synuclein in Lewy bodies is a pathological event not associated with impairment of proteasome function

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Caught in the act: alpha-synuclein is the culprit in Parkinson's disease

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Mechanism of prion propagation: amyloid growth occurs by monomer addition

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Viral vector mediated overexpression of human alpha-synuclein in the nigrostriatal dopaminergic neurons: a new model for Parkinson's disease.

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12 December 2020

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Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease

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Efficient selection for high-expression transfectants with a novel eukaryotic vector

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Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease

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The role of G-protein-coupled receptor kinase 5 in pathogenesis of sporadic Parkinson's disease.

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Mechanisms of Parkinson's disease linked to pathological alpha-synuclein: new targets for drug discovery

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12 December 2020

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The effect of truncated human alpha-synuclein (1-120) on dopaminergic cells in a transgenic mouse model of Parkinson's disease

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/22090514

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The phosphorylation state of Ser-129 in human alpha-synuclein determines neurodegeneration in a rat model of Parkinson disease

1 reference

stated in

PubMed

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https://pubmed.ncbi.nlm.nih.gov/22090514

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation at Ser-129 but not the phosphomimics S129E/D inhibits the fibrillation of alpha-synuclein.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/22090514

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based on heuristic

inferred from PubMed ID database lookup

Polo-like kinase 2 (PLK2) phosphorylates alpha-synuclein at serine 129 in central nervous system

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/22090514

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation does not prompt, nor prevent, the formation of alpha-synuclein toxic species in a rat model of Parkinson's disease

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/22090514

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

alpha-Synuclein and neuronal cell death

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/22090514

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human alpha-iduronidase gene transfer mediated by adeno-associated virus types 1, 2, and 5 in the brain of nonhuman primates: vector diffusion and biodistribution

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https://pubmed.ncbi.nlm.nih.gov/22090514

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contribution of endogenous G-protein-coupled receptor kinases to Ser129 phosphorylation of alpha-synuclein in HEK293 cells.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/22090514

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based on heuristic

inferred from PubMed ID database lookup

Alpha-synuclein S129 phosphorylation mutants do not alter nigrostriatal toxicity in a rat model of Parkinson disease

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PubMed

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tyrosine and serine phosphorylation of alpha-synuclein have opposing effects on neurotoxicity and soluble oligomer formation

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PubMed

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12 December 2020

based on heuristic

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Phosphorylation of synucleins by members of the Polo-like kinase family

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PubMed

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Serine 129 phosphorylation reduces the ability of alpha-synuclein to regulate tyrosine hydroxylase and protein phosphatase 2A in vitro and in vivo.

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based on heuristic

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Genetic animal models of Parkinson's disease

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PubMed

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12 December 2020

based on heuristic

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Phosphorylated α-Synuclein at Ser-129 Is Targeted to the Proteasome Pathway in a Ubiquitin-independent Manner

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PubMed

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced phosphatase activity attenuates α-synucleinopathy in a mouse model

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PubMed

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glial cell line-derived neurotrophic factor but not transforming growth factor beta 3 prevents delayed degeneration of nigral dopaminergic neurons following striatal 6-hydroxydopamine lesion

1 reference

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PubMed

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The hepatitis B virus posttranscriptional regulatory element is composed of two subelements

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/22090514

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha-synuclein in Lewy bodies

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/22090514

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular cloning of rat G-protein-coupled receptor kinase 6 (GRK6) from brain tissue, and its mRNA expression in different brain regions and peripheral tissues

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/22090514

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Midbrain injection of recombinant adeno-associated virus encoding rat glial cell line-derived neurotrophic factor protects nigral neurons in a progressive 6-hydroxydopamine-induced degeneration model of Parkinson's disease in rats

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/22090514

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/22090514

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12 December 2020

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inferred from PubMed ID database lookup

Identifiers

DOI

10.1523/JNEUROSCI.3967-11.2011

1 reference

stated in

Europe PubMed Central

PMC publication ID

6633319

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22090514%20AND%20SRC:MED&resulttype=core&format=json

retrieved

16 January 2020

PMC publication ID

6633319

1 reference

stated in

Europe PubMed Central

PMC publication ID

6633319

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22090514%20AND%20SRC:MED&resulttype=core&format=json

retrieved

16 January 2020

PubMed publication ID

22090514

1 reference

stated in

Europe PubMed Central

PMC publication ID

6633319

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22090514%20AND%20SRC:MED&resulttype=core&format=json

retrieved

16 January 2020

 

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