The Sel1L-Hrd1 Endoplasmic Reticulum-Associated Degradation Complex Manages a Key Checkpoint in B Cell Development (Q39446306)

12 September 2017

The Sel1L-Hrd1 Endoplasmic Reticulum-Associated Degradation Complex Manages a Key Checkpoint in B Cell Development (English)

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12 September 2017

endoplasmic reticulum

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13 June 2020

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13 June 2020

Yewei Ji

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13 June 2020

Hana Kim

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13 June 2020

Liu Yang

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13 June 2020

Haibo Sha

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13 June 2020

Christopher A Roman

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13 June 2020

language of work or name

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24 August 2016

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12 September 2017

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13 June 2020

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13 June 2020

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13 June 2020

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2630-2640

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Epithelial Sel1L is required for the maintenance of intestinal homeostasis

13 June 2020

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1 reference

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IRE1α is an endogenous substrate of endoplasmic-reticulum-associated degradation

12 September 2017

1 reference

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The E3 ligase synoviolin controls body weight and mitochondrial biogenesis through negative regulation of PGC-1β

12 September 2017

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Hrd1-mediated BLIMP-1 ubiquitination promotes dendritic cell MHCII expression for CD4 T cell priming during inflammation

12 September 2017

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The ER-associated degradation adaptor protein Sel1L regulates LPL secretion and lipid metabolism

12 September 2017

1 reference

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Diet-induced alterations in gut microflora contribute to lethal pulmonary damage in TLR2/TLR4-deficient mice

12 September 2017

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Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosis

12 September 2017

1 reference

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Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival

12 September 2017

1 reference

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Orchestrating B cell lymphopoiesis through interplay of IL-7 receptor and pre-B cell receptor signalling

12 September 2017

1 reference

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The unfolded protein response transducer ATF6 represents a novel transmembrane-type endoplasmic reticulum-associated degradation substrate requiring both mannose trimming and SEL1L protein

12 September 2017

1 reference

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The mammalian endoplasmic reticulum-associated degradation system

12 September 2017

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Unassembled CD147 is an endogenous endoplasmic reticulum-associated degradation substrate

12 September 2017

1 reference

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Short term high fat diet challenge promotes alternative macrophage polarization in adipose tissue via natural killer T cells and interleukin-4.

12 September 2017

1 reference

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The delicate balance between secreted protein folding and endoplasmic reticulum-associated degradation in human physiology

12 September 2017

1 reference

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The unfolded protein response: controlling cell fate decisions under ER stress and beyond

12 September 2017

1 reference

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Stressed out about obesity: IRE1α-XBP1 in metabolic disorders

12 September 2017

1 reference

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Processing and turnover of the Hedgehog protein in the endoplasmic reticulum

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014582

Deficiency of suppressor enhancer Lin12 1 like (SEL1L) in mice leads to systemic endoplasmic reticulum stress and embryonic lethality

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014582

XBP1 governs late events in plasma cell differentiation and is not required for antigen-specific memory B cell development

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014582

Regulation of B-cell proliferation and differentiation by pre-B-cell receptor signalling

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014582

SPFH2 mediates the endoplasmic reticulum-associated degradation of inositol 1,4,5-trisphosphate receptors and other substrates in mammalian cells

12 September 2017

1 reference

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The pre-B-cell receptor: selector of fitting immunoglobulin heavy chains for the B-cell repertoire

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014582

The unfolded protein response sensor IRE1alpha is required at 2 distinct steps in B cell lymphopoiesis.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014582

B cell progenitors are arrested in maturation but have intact VDJ recombination in the absence of Ig-alpha and Ig-beta

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014582

Differential surrogate light chain expression governs B-cell differentiation

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014582

Conventional and surrogate light chains differentially regulate Ig mu and Dmu heavy chain maturation and surface expression

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014582

Plasma cell differentiation requires the transcription factor XBP-1

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014582

Induction of pre-B cell proliferation after de novo synthesis of the pre-B cell receptor

12 September 2017

1 reference

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Abnormal development and function of B lymphocytes in mice deficient for the signaling adaptor protein SLP-65

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014582

Mutations in Igalpha (CD79a) result in a complete block in B-cell development

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014582

BiP and immunoglobulin light chain cooperate to control the folding of heavy chain and ensure the fidelity of immunoglobulin assembly

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014582

Novel mechanisms control the folding and assembly of lambda5/14.1 and VpreB to produce an intact surrogate light chain

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014582

Mutations in the human lambda5/14.1 gene result in B cell deficiency and agammaglobulinemia

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014582

Fate of surrogate light chains in B lineage cells

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014582

Bone marrow pre-B lymphocytes synthesize immunoglobulin mu chains of membrane type with different properties and intracellular pathways

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014582

Structure and domain organization of the CD19 antigen of human, mouse, and guinea pig B lymphocytes. Conservation of the extensive cytoplasmic domain

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014582

The pre-B-cell receptor induces silencing of VpreB and lambda5 transcription.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014582

B lymphocyte-specific, Cre-mediated mutagenesis in mice

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014582

Maintenance of surrogate light chain expression induces developmental delay in early B cell compartment

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014582

Murine B cell leukemia line with inducible surface immunoglobulin expression

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014582

Loss of precursor B cell expansion but not allelic exclusion in VpreB1/VpreB2 double-deficient mice

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014582

Immunoglobulin heavy chain and binding protein complexes are dissociated in vivo by light chain addition

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014582

The expression of the mouse VpreB/lambda 5 locus in transformed cell lines and tumors of the B lineage differentiation pathway

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014582

The role of immunoglobulin heavy chain binding protein in immunoglobulin transport

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014582

AB5 subtilase cytotoxin inactivates the endoplasmic reticulum chaperone BiP.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014582

The nonimmunoglobulin portion of lambda5 mediates cell-autonomous pre-B cell receptor signaling

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014582

The adaptor protein SLP-65 acts as a tumor suppressor that limits pre-B cell expansion.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014582

Glycoprotein quality control in the endoplasmic reticulum. Mannose trimming by endoplasmic reticulum mannosidase I times the proteasomal degradation of unassembled immunoglobulin subunits

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014582

Regulation of an early developmental checkpoint in the B cell pathway by Ig beta.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014582

Formation of disulphide-linked µ2ω2 tetramers in pre-B cells by the 18K ω-immunoglobulin light chain

21 August 2018

1 reference

12 December 2020

VpreB1/VpreB2/lambda 5 triple-deficient mice show impaired B cell development but functional allelic exclusion of the IgH locus

1 reference

12 December 2020

A critical role of λ5 protein in B cell development

1 reference

12 December 2020

Surrogate-light-chain silencing is not critical for the limitation of pre-B cell expansion but is for the termination of constitutive signaling

1 reference

12 December 2020

Assembled pre-B cell receptor complexes are retained in the endoplasmic reticulum by a mechanism that is not selective for the pseudo-light chain

1 reference

12 December 2020

Targeted disruption of mu chain membrane exon causes loss of heavy-chain allelic exclusion

1 reference

12 December 2020

10.1016/J.CELREP.2016.08.003

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27568564%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

1 reference

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13 June 2020

PubMed publication ID

27568564

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27568564%20AND%20SRC:MED&resulttype=core&format=json