Induction of apoptosis by double-stranded-RNA-dependent protein kinase (PKR) involves the alpha subunit of eukaryotic translation initiation factor 2 and NF-kappaB. (Q39446101)

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English	Induction of apoptosis by double-stranded-RNA-dependent protein kinase (PKR) involves the alpha subunit of eukaryotic translation initiation factor 2 and NF-kappaB.	scientific article

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scholarly article

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Europe PubMed Central

PMC publication ID

12 September 2017

Induction of apoptosis by double-stranded-RNA-dependent protein kinase (PKR) involves the alpha subunit of eukaryotic translation initiation factor 2 and NF-kappaB. (English)

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Europe PubMed Central

PMC publication ID

12 September 2017

apoptotic process

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author name string

J Gil

1

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Europe PubMed Central

PMC publication ID

12 September 2017

J Alcamí

2

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Europe PubMed Central

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12 September 2017

M Esteban

3

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Europe PubMed Central

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12 September 2017

language of work or name

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publication date

1 July 1999

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Europe PubMed Central

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12 September 2017

Molecular and Cellular Biology

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Europe PubMed Central

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12 September 2017

19

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Europe PubMed Central

PMC publication ID

12 September 2017

7

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

4653-4663

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

TPL-2 kinase regulates the proteolysis of the NF-kappaB-inhibitory protein NF-kappaB1 p105

1 reference

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How cells respond to interferons

1 reference

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NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation

1 reference

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A mutant cell line defective in response to double-stranded RNA and in regulating basal expression of interferon-stimulated genes

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Suppression of steady-state, but not stimulus-induced NF-kappaB activity inhibits alphavirus-induced apoptosis

1 reference

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Interferon action and apoptosis are defective in mice devoid of 2',5'-oligoadenylate-dependent RNase L

1 reference

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Ikappa Balpha is a target for the mitogen-activated 90kDa ribosomal S6 kinase

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1 reference

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When two strands are better than one: the mediators and modulators of the cellular responses to double-stranded RNA.

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Thiol agents and Bcl-2 identify an alphavirus-induced apoptotic pathway that requires activation of the transcription factor NF-kappa B.

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Double-stranded RNA-dependent protein kinase activates transcription factor NF-kappa B by phosphorylating I kappa B.

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Even viruses can learn to cope with stress

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https://pubmed.ncbi.nlm.nih.gov/10373514

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The Interferon-Induced Double-Stranded RNA-Activated Human p68 Protein Kinase Potently Inhibits Protein Synthesis in Cultured Cells

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https://pubmed.ncbi.nlm.nih.gov/10373514

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High levels of c-rel expression are associated with programmed cell death in the developing avian embryo and in bone marrow cells in vitro

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https://pubmed.ncbi.nlm.nih.gov/10373514

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based on heuristic

inferred from PubMed ID database lookup

The interferon-induced double-stranded RNA-activated protein kinase induces apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/10373514

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based on heuristic

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Tyrosine phosphorylation of I kappa B-alpha activates NF-kappa B without proteolytic degradation of I kappa B-alpha

1 reference

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The apoptosis pathway triggered by the interferon-induced protein kinase PKR requires the third basic domain, initiates upstream of Bcl-2, and involves ICE-like proteases

1 reference

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Identifiers

10.1128/MCB.19.7.4653

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

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