Antitumor activity of new pyrazolo[3,4-d]pyrimidine SRC kinase inhibitors in Burkitt lymphoma cell lines and its enhancement by WEE1 inhibition (Q39396721)

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English	Antitumor activity of new pyrazolo[3,4-d]pyrimidine SRC kinase inhibitors in Burkitt lymphoma cell lines and its enhancement by WEE1 inhibition	scientific article

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Europe PubMed Central

PubMed publication ID

11 September 2017

Antitumor activity of new pyrazolo[3,4-d]pyrimidine SRC kinase inhibitors in Burkitt lymphoma cell lines and its enhancement by WEE1 inhibition (English)

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11 September 2017

Burkitt lymphoma

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Antonio Giordano

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11 September 2017

Francesca Pentimalli

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Francesca Pentimalli

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Iris Maria Forte

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Iris Maria Forte

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Maurizio Botta

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11 September 2017

11

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Paola Indovina

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11 September 2017

Vittorio D'Urso

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Vittorio D'Urso

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11 September 2017

Silvia Schenone

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Silvia Schenone

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11 September 2017

Eleonora Marcelli

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Eleonora Marcelli

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1

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Martina Cozzi

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11 September 2017

Giulia De Falco

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Giulia De Falco

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11 September 2017

author name string

Francesca Giorgi

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11 September 2017

publication date

1 March 2012

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11 September 2017

number of pages

11

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11 September 2017

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11 September 2017

1029-1039

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11 September 2017

The molecular background of aggressive B cell lymphomas as a basis for targeted therapy

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https://api.crossref.org/works/10.4161%2FCC.11.5.19519

21 January 2018

Burkitt's lymphoma: clinicopathologic features and differential diagnosis

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Selective killing of Burkitt's lymphoma cells by mBAFF-targeted delivery of PinX1

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Role of genetic and epigenetic changes in Burkitt lymphoma

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A renaissance for SRC

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Tyrosine kinase inhibition in diffuse large B-cell lymphoma: molecular basis for antitumor activity and drug resistance of dasatinib.

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Anomalous constitutive Src kinase activity promotes B lymphoma survival and growth

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Therapeutic implications of Src independent calcium mobilization in diffuse large B-cell lymphoma

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Novel dual Src/Abl inhibitors for hematologic and solid malignancies

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Dasatinib inhibits migration and invasion in diverse human sarcoma cell lines and induces apoptosis in bone sarcoma cells dependent on SRC kinase for survival

1 reference

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Inhibition of Src with AZD0530 reveals the Src-Focal Adhesion kinase complex as a novel therapeutic target in papillary and anaplastic thyroid cancer.

1 reference

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Src kinase phosphorylates Caspase-8 on Tyr380: a novel mechanism of apoptosis suppression

1 reference

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SRC directly phosphorylates Bif-1 and prevents its interaction with Bax and the initiation of anoikis

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Control of M-phase by maturation-promoting factor

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21 January 2018

Chk1 is a wee1 kinase in the G2 DNA damage checkpoint inhibiting cdc2 by Y15 phosphorylation.

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21 January 2018

Cdc25 and Wee1: analogous opposites?

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Ras, PI(3)K and mTOR signalling controls tumour cell growth

1 reference

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21 January 2018

AKT inhibitor, GSK690693, induces growth inhibition and apoptosis in acute lymphoblastic leukemia cell lines

1 reference

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21 January 2018

Regulation of Akt/PKB activation by tyrosine phosphorylation

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21 January 2018

Akt/protein kinase B-dependent phosphorylation and inactivation of WEE1Hu promote cell cycle progression at G2/M transition

1 reference

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21 January 2018

M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP

1 reference

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21 January 2018

Targeting the checkpoint kinases: chemosensitization versus chemoprotection

1 reference

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21 January 2018

p53-based cancer therapies: Is defective p53 the Achilles heel of the tumor?

1 reference

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21 January 2018

Knockdown of Chk1, Wee1 and Myt1 by RNA interference abrogates G2 checkpoint and induces apoptosis

1 reference

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21 January 2018

Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents

1 reference

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21 January 2018

MK-1775, a small molecule Wee1 inhibitor, enhances anti-tumor efficacy of various DNA-damaging agents, including 5-fluorouracil

1 reference

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Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

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AXL is a potential target for therapeutic intervention in breast cancer progression.

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New pyrazolo[3,4-d]pyrimidines endowed with A431 antiproliferative activity and inhibitory properties of Src phosphorylation.

1 reference

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21 January 2018

Pyrazolo[3,4-d]pyrimidines as potent antiproliferative and proapoptotic agents toward A431 and 8701-BC cells in culture via inhibition of c-Src phosphorylation.

1 reference

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21 January 2018

Antiproliferative and proapoptotic activities of new pyrazolo[3,4-d]pyrimidine derivative Src kinase inhibitors in human osteosarcoma cells

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Requirement for Src family protein tyrosine kinases in G2 for fibroblast cell division

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New pyrazolo-[3,4-d]-pyrimidine derivative Src kinase inhibitors lead to cell cycle arrest and tumor growth reduction of human medulloblastoma cells

1 reference

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Cyclin-dependent kinase-1: linking apoptosis to cell cycle and mitotic catastrophe.

1 reference

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Coordinated synthesis and degradation of cdc2 in the mammalian cell cycle

1 reference

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Effects of adenoviral wild-type p53 gene transfer in p53-mutated lymphoma cells

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21 January 2018

Synthesis, biological evaluation and docking studies of 4-amino substituted 1H-pyrazolo[3,4-d]pyrimidines

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Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

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Identifiers

10.4161/CC.11.5.19519

1 reference

Europe PubMed Central

PubMed publication ID

11 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

11 September 2017

ResearchGate publication ID

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