Maintenance of acinar cell organization is critical to preventing Kras-induced acinar-ductal metaplasia. (Q39337159)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22665051%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

title

Maintenance of acinar cell organization is critical to preventing Kras-induced acinar-ductal metaplasia (English)

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3 February 2020

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3 February 2020

D DiRenzo

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3 February 2020

C Qu

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3 February 2020

D Barney

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3 February 2020

D Miley

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3 February 2020

S F Konieczny

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3 February 2020

language of work or name

English

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publication date

4 June 2012

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3 February 2020

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3 February 2020

volume

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3 February 2020

issue

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3 February 2020

page(s)

1950-1958

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Acute pancreatitis accelerates initiation and progression to pancreatic cancer in mice expressing oncogenic Kras in the nestin cell lineage

3 February 2020

cites work

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Beta-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice

11 September 2017

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Context-dependent transformation of adult pancreatic cells by oncogenic K-Ras

11 September 2017

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Acute pancreatitis markedly accelerates pancreatic cancer progression in mice expressing oncogenic Kras

11 September 2017

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11 September 2017

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KRAS2 mutations in human pancreatic acinar-ductal metaplastic lesions are limited to those with PanIN: implications for the human pancreatic cancer cell of origin

11 September 2017

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Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia

11 September 2017

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11 September 2017

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In vivo lineage tracing defines the role of acinar-to-ductal transdifferentiation in inflammatory ductal metaplasia

11 September 2017

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Acinar cells contribute to the molecular heterogeneity of pancreatic intraepithelial neoplasia

11 September 2017

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The Nestin progenitor lineage is the compartment of origin for pancreatic intraepithelial neoplasia

11 September 2017

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The maturation of mucus-secreting gastric epithelial progenitors into digestive-enzyme secreting zymogenic cells requires Mist1

11 September 2017

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Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer

11 September 2017

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Multifocal neoplastic precursor lesions associated with lobular atrophy of the pancreas in patients having a strong family history of pancreatic cancer.

11 September 2017

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11 September 2017

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Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse

11 September 2017

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Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice

11 September 2017

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11 September 2017

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Inhibition of Mist1 homodimer formation induces pancreatic acinar-to-ductal metaplasia

11 September 2017

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11 September 2017

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11 September 2017

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11 September 2017

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11 September 2017

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The bHLH transcription factor Mist1 is required to maintain exocrine pancreas cell organization and acinar cell identity

11 September 2017

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11 September 2017

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11 September 2017

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11 September 2017

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14 September 2017

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14 September 2017

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17 June 2018

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17 June 2018

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17 June 2018

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21 August 2018

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Concomitant pancreatic activation of Kras(G12D) and Tgfa results in cystic papillary neoplasms reminiscent of human IPMN.

21 August 2018

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21 August 2018

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21 August 2018

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Successful growth and characterization of mouse pancreatic ductal cells: functional properties of the Ki-RAS(G12V) oncogene

21 August 2018

1 reference

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The mutant K-ras oncogene causes pancreatic periductal lymphocytic infiltration and gastric mucous neck cell hyperplasia in transgenic mice.

21 August 2018

1 reference

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Chronic Pancreatitis Is Essential for Induction of Pancreatic Ductal Adenocarcinoma by K-Ras Oncogenes in Adult Mice

21 August 2018

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Pancreatic epithelial plasticity mediated by acinar cell transdifferentiation and generation of nestin-positive intermediates

31 March 2020

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Mist1-KrasG12D knock-in mice develop mixed differentiation metastatic exocrine pancreatic carcinoma and hepatocellular carcinoma

31 March 2020

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Overexpression of TGFα in transgenic mice: Induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast

31 March 2020

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Malignant transformation of duct-like cells originating from acini in transforming growth factor transgenic mice

31 March 2020

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Pancreatic fibrosis associated with age and ductal papillary hyperplasia

31 March 2020

1 reference

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31 March 2020

Identifiers

DOI

10.1038/ONC.2012.210

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22665051%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

1 reference

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3 February 2020

PubMed publication ID

22665051

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22665051%20AND%20SRC:MED&resulttype=core&format=json