Development of a profiling strategy for metabolic mixtures by combining chromatography and mass spectrometry with cell-based GPCR signaling (Q39323929)

11 September 2017

title

Development of a profiling strategy for metabolic mixtures by combining chromatography and mass spectrometry with cell-based GPCR signaling (English)

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G protein-coupled receptor

11 September 2017

main subject

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Saskia Nijmeijer

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David Falck

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Henry F Vischer

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11 September 2017

Anders F Rudebeck

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11 September 2017

Frank Fleurbaaij

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11 September 2017

Rob Leurs

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11 September 2017

Wilfried M A Niessen

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11 September 2017

Jeroen Kool

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11 September 2017

publication date

26 June 2012

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Journal of Biomolecular Screening

11 September 2017

published in

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11 September 2017

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11 September 2017

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11 September 2017

page(s)

1329-1338

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Molecular cloning and characterization of a novel type of histamine receptor preferentially expressed in leukocytes

11 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1177%2F1087057112451922

Molecular and biochemical pharmacology of the histamine H4 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112451922

Identification of a histamine H4 receptor on human eosinophils--role in eosinophil chemotaxis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112451922

En route to new blockbuster anti-histamines: surveying the offspring of the expanding histamine receptor family

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112451922

UR-60427, a novel H4 receptor-inverse agonist that shows good efficacy in a rat asthma model

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112451922

Rotationally constrained 2,4-diamino-5,6-disubstituted pyrimidines: a new class of histamine H4 receptor antagonists with improved druglikeness and in vivo efficacy in pain and inflammation models

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112451922

The first potent and selective non-imidazole human histamine H4 receptor antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112451922

Identification of 2-arylbenzimidazoles as potent human histamine H4 receptor ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112451922

Discovery of S-(2-guanidylethyl)-isothiourea (VUF 8430) as a potent nonimidazole histamine H4 receptor agonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112451922

Synthesis and QSAR of quinazoline sulfonamides as highly potent human histamine H4 receptor inverse agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112451922

A New Classification of Prodrugs: Regulatory Perspectives

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112451922

Pharmacokinetics of opioids in liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112451922

Clinical Pharmacokinetics of Diazepam

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112451922

Enzyme-catalyzed activation of anticancer prodrugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112451922

Discovering drugs through biological transformation: role of pharmacologically active metabolites in drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112451922

Mechanisms of Drug Toxicity and Relevance to Pharmaceutical Development

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112451922

Metabolic bioactivation and drug-related adverse effects: current status and future directions from a pharmaceutical research perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112451922

Bioactivation of drugs: risk and drug design

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112451922

Microfractionation revisited: a 1536 well high resolution screening assay.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112451922

Nanofractionation spotter technology for rapid contactless and high-resolution deposition of LC eluent for further off-line analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112451922

High-resolution metabolic profiling towards G protein-coupled receptors: rapid and comprehensive screening of histamine H₄ receptor ligands.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112451922

In vitro and in vivo characterization of A-940894: a potent histamine H4 receptor antagonist with anti-inflammatory properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112451922

Evaluation of histamine H1-, H2-, and H3-receptor ligands at the human histamine H4 receptor: identification of 4-methylhistamine as the first potent and selective H4 receptor agonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112451922

Reversed-phase liquid chromatography coupled on-line to estrogen receptor bioaffinity detection based on fluorescence polarization

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112451922

Fragment based design of new H4 receptor-ligands with anti-inflammatory properties in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112451922

Clozapine--pharmacokinetic investigations and biochemical effects in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112451922

The clozapine metabolite N-desmethylclozapine displays variable activity in diverse functional assays at human dopamine D2 and serotonin 5-HT1A receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112451922

21 January 2018

Identifiers

DOI

10.1177/1087057112451922

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11 September 2017

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