Pyruvate kinase type M2 is upregulated in colorectal cancer and promotes proliferation and migration of colon cancer cells (Q39312837)

10 September 2017

title

Pyruvate kinase type M2 is upregulated in colorectal cancer and promotes proliferation and migration of colon cancer cells (English)

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10 September 2017

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Cheng-Fu Zhou

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10 September 2017

Xue-Bing Li

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10 September 2017

Heng Sun

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10 September 2017

Bo Zhang

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Yu-Song Han

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10 September 2017

Yi Jiang

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10 September 2017

Qiu-Lin Zhuang

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10 September 2017

Jing Fang

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10 September 2017

Guo-Hao Wu

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10 September 2017

publication date

18 July 2012

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10 September 2017

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page(s)

775-782

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Glucose avidity of carcinomas.

10 September 2017

cites work

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Pyruvate kinase type M2 and its role in tumor growth and spreading

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Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth

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Prolyl hydroxylase-3 is down-regulated in colorectal cancer cells and inhibits IKKbeta independent of hydroxylase activity

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Apigenin inhibited migration and invasion of human ovarian cancer A2780 cells through focal adhesion kinase

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Isotype-specific inhibitors of the glycolytic key regulator pyruvate kinase subtype M2 moderately decelerate tumor cell proliferation

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The metabolic marker tumour pyruvate kinase type M2 (tumour M2-PK) shows increased expression along the metaplasia-dysplasia-adenocarcinoma sequence in Barrett's oesophagus

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No evidence for a shift in pyruvate kinase PKM1 to PKM2 expression during tumorigenesis

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Pyruvate kinase isoenzyme M2 is a glycolytic sensor differentially regulating cell proliferation, cell size and apoptotic cell death dependent on glucose supply

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Breast cancer stromal myxoid changes are associated with tumor invasion and metastasis: a central role for hyaluronan

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Tumorigenesis suppressor Pdcd4 down-regulates mitogen-activated protein kinase kinase kinase kinase 1 expression to suppress colon carcinoma cell invasion

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Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer

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Ketones and lactate "fuel" tumor growth and metastasis: Evidence that epithelial cancer cells use oxidative mitochondrial metabolism

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Lactate promotes glioma migration by TGF-beta2-dependent regulation of matrix metalloproteinase-2.

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Lactate stimulates endothelial cell migration.

21 January 2018

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Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-κB/IL-8 pathway that drives tumor angiogenesis

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Regulation of tumor pH and the role of carbonic anhydrase 9.

21 January 2018

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Silencing of pkm2 increases the efficacy of docetaxel in human lung cancer xenografts in mice

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21 January 2018

Identifiers

DOI

10.1002/IUB.1066

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10 September 2017

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