Telomerase directly regulates NF-κB-dependent transcription. (Q39243328)

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18 February 2020

title

Telomerase directly regulates NF-κB-dependent transcription (English)

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18 February 2020

Shi Chi Leow

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18 February 2020

Ekta Khattar

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18 February 2020

Eun Myong Shin

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18 February 2020

Ting Dong Yan

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18 February 2020

Marc Wong

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Zhizhuo Zhang

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Jianbiao Zhou

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Wee Joo Chng

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18 February 2020

Shang Li

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18 February 2020

Edison Liu

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Vinay Tergaonkar

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Guoliang Li

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18 February 2020

publication date

18 November 2012

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18 February 2020

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18 February 2020

volume

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issue

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18 February 2020

page(s)

1270-1281

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Recognition and elongation of telomeres by telomerase

18 February 2020

cites work

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Constitutive telomerase expression promotes mammary carcinomas in aging mice

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Differential regulation of telomerase activity and telomerase RNA during multi-stage tumorigenesis

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Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53-dependent cellular senescence

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Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes.

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Telomerase activation in atherosclerosis and induction of telomerase reverse transcriptase expression by inflammatory stimuli in macrophages

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A telomerase component is defective in the human disease dyskeratosis congenita

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Reversible cell-cycle entry in adult kidney podocytes through regulated control of telomerase and Wnt signaling

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Telomerase modulates Wnt signalling by association with target gene chromatin

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hTERT Overexpression Alleviates Intracellular ROS Production, Improves Mitochondrial Function, and Inhibits ROS-Mediated Apoptosis in Cancer Cells

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Separation of telomerase functions by reverse genetics

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The telomerase reverse transcriptase regulates chromatin state and DNA damage responses.

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The Telomerase Inhibitor Imetelstat Depletes Cancer Stem Cells in Breast and Pancreatic Cancer Cell Lines

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Telomerase reverse transcriptase protects ATM-deficient hematopoietic stem cells from ROS-induced apoptosis through a telomere-independent mechanism.

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Shared principles in NF-kappaB signaling

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Telomere-independent Rap1 is an IKK adaptor and regulates NF-kappaB-dependent gene expression

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Inflammation meets cancer, with NF-κB as the matchmaker

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ATM- and NEMO-Dependent ELKS Ubiquitination Coordinates TAK1-Mediated IKK Activation in Response to Genotoxic Stress

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Integrating cell-signalling pathways with NF-kappaB and IKK function

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Degradation of promoter-bound p65/RelA is essential for the prompt termination of the nuclear factor kappaB response

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WIP1 phosphatase is a negative regulator of NF-kappaB signalling

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Mutations in the IkBa gene in Hodgkin's disease suggest a tumour suppressor role for IkappaBalpha.

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Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

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Suppression of TNF-alpha-induced apoptosis by NF-kappaB

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Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection

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Tumor necrosis factor alpha mediates the lethal hepatotoxic effects of poly(I:C) in D-galactosamine-sensitized mice

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NF-kappa B regulates transcription of the mouse telomerase catalytic subunit

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The nuclear factor-kappaB engages CBP/p300 and histone acetyltransferase activity for transcriptional activation of the interleukin-6 gene promoter.

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Mechanism of telomerase induction during T cell activation

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Ulcerative Typhlocolitis Associated With Helicobacter mastomyrinus in Telomerase-Deficient Mice

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Genomic maps of long noncoding RNA occupancy reveal principles of RNA-chromatin interactions

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DNA damage-mediated induction of a chemoresistant niche

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Rapid inhibition of cancer cell growth induced by lentiviral delivery and expression of mutant-template telomerase RNA and anti-telomerase short-interfering RNA.

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12 December 2020

The diverse and complex roles of NF-κB subunits in cancer

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12 December 2020

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12 December 2020

Identifiers

DOI

10.1038/NCB2621

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18 February 2020

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