Uncoupling protein 2 and metabolic diseases (Q39205505)

18 May 2018

title

Uncoupling protein 2 and metabolic diseases (English)

1 reference

18 May 2018

author name string

Annapoorna Sreedhar

series ordinal

1 reference

18 May 2018

Yunfeng Zhao

series ordinal

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18 May 2018

publication date

25 March 2017

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18 May 2018

published in

Mitochondrion

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18 May 2018

volume

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18 May 2018

page(s)

135-140

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18 May 2018

Mitochondrial dysfunction and oxidative stress in aging and cancer

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UCP2 transports C4 metabolites out of mitochondria, regulating glucose and glutamine oxidation.

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UCP2 overexpression worsens mitochondrial dysfunction and accelerates disease progression in a mouse model of amyotrophic lateral sclerosis

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Associations between UCP1 -3826A/G, UCP2 -866G/A, Ala55Val and Ins/Del, and UCP3 -55C/T polymorphisms and susceptibility to type 2 diabetes mellitus: case-control study and meta-analysis

15 June 2018

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Beta-cell uncoupling protein 2 regulates reactive oxygen species production, which influences both insulin and glucagon secretion

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New aspects of mitochondrial Uncoupling Proteins (UCPs) and their roles in tumorigenesis

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15 June 2018

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Mitochondrial recoupling: a novel therapeutic strategy for cancer?

15 June 2018

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Uncoupling protein 2 negatively regulates mitochondrial reactive oxygen species generation and induces phosphatase-mediated anti-inflammatory response in experimental visceral leishmaniasis

15 June 2018

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Genetic Variance in Uncoupling Protein 2 in Relation to Obesity, Type 2 Diabetes, and Related Metabolic Traits: Focus on the Functional -866G>A Promoter Variant (rs659366)

15 June 2018

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The regulation and turnover of mitochondrial uncoupling proteins.

15 June 2018

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Uncoupling protein-2 and cancer

15 June 2018

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UCP2, not a physiologically relevant uncoupler but a glucose sparing switch impacting ROS production and glucose sensing

15 June 2018

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Uncoupling protein-2 regulates lifespan in mice.

15 June 2018

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Mutations in UCP2 in congenital hyperinsulinism reveal a role for regulation of insulin secretion

15 June 2018

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Cancer is a preventable disease that requires major lifestyle changes

15 June 2018

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On the role of uncoupling protein-2 in pancreatic beta cells.

15 June 2018

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The mitochondrial uncoupling protein-2 promotes chemoresistance in cancer cells

15 June 2018

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Metabolic syndrome, hyperinsulinemia, and colon cancer: a review

15 June 2018

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Uncoupling proteins: role in insulin resistance and insulin insufficiency

15 June 2018

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The biology of cancer: metabolic reprogramming fuels cell growth and proliferation

15 June 2018

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Role of uncoupling protein UCP2 in cell-mediated immunity: how macrophage-mediated insulitis is accelerated in a model of autoimmune diabetes.

15 June 2018

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The metabolic syndrome: A high-risk state for cancer?

15 June 2018

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15 June 2018

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Uncoupling proteins, dietary fat and the metabolic syndrome

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5477468

Uncoupling protein 2 has protective function during experimental autoimmune encephalomyelitis.

15 June 2018

1 reference

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The emerging functions of UCP2 in health, disease, and therapeutics

15 June 2018

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Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3.

15 June 2018

1 reference

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Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome: a summary of the evidence

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5477468

Expression of uncoupling protein-2 in human colon cancer.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5477468

Mitochondrial superoxide: production, biological effects, and activation of uncoupling proteins

15 June 2018

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The biology of mitochondrial uncoupling proteins

15 June 2018

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Brown adipose tissue: function and physiological significance

15 June 2018

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Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction.

15 June 2018

1 reference

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Radical causes of cancer.

15 June 2018

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The mitochondrial uncoupling proteins

15 June 2018

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The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men

15 June 2018

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Oxidative damage and phospholipid fatty acyl composition in skeletal muscle mitochondria from mice underexpressing or overexpressing uncoupling protein 3.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5477468

UCP2 and UCP3 in muscle controlling body metabolism

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5477468

Mitochondrial ROS metabolism: modulation by uncoupling proteins.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5477468

Superoxide activates mitochondrial uncoupling proteins

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5477468

Increased uncoupling protein-2 levels in beta-cells are associated with impaired glucose-stimulated insulin secretion: mechanism of action

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5477468

Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5477468

Mitochondrial uncoupling proteins: from mitochondria to the regulation of energy balance

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5477468

The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP

15 June 2018

1 reference

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Mitochondria and neuronal survival

15 June 2018

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UCP4, a novel brain-specific mitochondrial protein that reduces membrane potential in mammalian cells

15 June 2018

1 reference

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BMCP1, a novel mitochondrial carrier with high expression in the central nervous system of humans and rodents, and respiration uncoupling activity in recombinant yeast

15 June 2018

1 reference

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Association between uncoupling protein polymorphisms (UCP2-UCP3) and energy metabolism/obesity in Pima indians.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5477468

Increased uncoupling protein-2 and -3 mRNA expression during fasting in obese and lean humans.

15 June 2018

1 reference

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Uncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expression

15 June 2018

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Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia

15 June 2018

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The two "hit" and multiple "hit" theories of carcinogenesis

15 June 2018

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Mutation and cancer: statistical study of retinoblastoma

15 June 2018

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Expression of uncoupling protein mRNA in thermogenic or weakly thermogenic brown adipose tissue. Evidence for a rapid beta-adrenoreceptor-mediated and transcriptionally regulated step during activation of thermogenesis

15 June 2018

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Diabetes and cardiovascular disease. The Framingham study

15 June 2018

1 reference

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UCP2 knockout suppresses mouse skin carcinogenesis.

15 June 2018

1 reference

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Cancer metabolism: fatty acid oxidation in the limelight

17 June 2018

1 reference

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Mitochondrial dysfunction and cancer metastasis

17 June 2018

1 reference

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Uncoupling protein UCP2: when mitochondrial activity meets immunity.

17 June 2018

1 reference

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Oxidative stress and neurodegenerative diseases: a review of upstream and downstream antioxidant therapeutic options

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5477468

The warburg effect in leukemia-stroma cocultures is mediated by mitochondrial uncoupling associated with uncoupling protein 2 activation

17 June 2018

1 reference

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UCP2 is a mitochondrial transporter with an unusual very short half-life

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5477468

Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5477468

Cardiovascular morbidity and mortality associated with the metabolic syndrome

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5477468

Uncoupling protein 2: a possible link between fatty acid excess and impaired glucose-induced insulin secretion?

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5477468

Diet-induced changes in uncoupling proteins in obesity-prone and obesity-resistant strains of mice

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5477468

Chronic Alcohol Consumption Leads to a Tissue Specific Expression of Uncoupling Protein-2.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5477468

Mitochondrial uncoupling protein 2 is up-regulated in human head and neck, skin, pancreatic, and prostate tumors.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5477468

Breakthrough of the year 2013. Cancer immunotherapy

21 August 2018

1 reference

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UCP2, a metabolic sensor coupling glucose oxidation to mitochondrial metabolism?

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5477468

Uncoupling protein-2 controls proliferation by promoting fatty acid oxidation and limiting glycolysis-derived pyruvate utilization.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5477468

Targeted expression of the human uncoupling protein 2 (hUCP2) to adult neurons extends life span in the fly.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5477468

Evolution of mitochondrial uncoupling proteins: novel invertebrate UCP homologues suggest early evolutionary divergence of the UCP family

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5477468

Uncoupling protein-2 is critical for nigral dopamine cell survival in a mouse model of Parkinson's disease.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5477468

Uncoupling protein 2 knockout mice have enhanced insulin secretory capacity after a high-fat diet

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5477468

Role of ATP production and uncoupling protein-2 in the insulin secretory defect induced by chronic exposure to high glucose or free fatty acids and effects of peroxisome proliferator-activated receptor-gamma inhibition

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5477468

Mitochondrial dysfunction in cancer

21 August 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5477468

Diabetes and Cancer: A Consensus Report

2 December 2018

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12 December 2020

A role for uncoupling protein-2 as a regulator of mitochondrial hydrogen peroxide generation

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12 December 2020

The uncoupling protein 2 modulates the cytokine balance in innate immunity

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12 December 2020

A new approach to the adoptive immunotherapy of cancer with tumor-infiltrating lymphocytes

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12 December 2020

Activation of the potato plant uncoupling mitochondrial protein inhibits reactive oxygen species generation by the respiratory chain

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12 December 2020

Association study of the -866G/A UCP2 gene promoter polymorphism with type 2 diabetes and obesity in a Tehran population: a case control study

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12 December 2020

Uncoupling protein 2, in vivo distribution, induction upon oxidative stress, and evidence for translational regulation

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12 December 2020

10.1016/J.MITO.2017.03.005

Identifiers

DOI

1 reference

18 May 2018

PMC publication ID

5477468

1 reference

18 May 2018

PubMed publication ID

28351676

1 reference

18 May 2018