Liquid biopsies come of age: towards implementation of circulating tumour DNA. (Q39149201)

9 September 2017

title

Liquid biopsies come of age: towards implementation of circulating tumour DNA. (English)

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9 September 2017

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13 June 2020

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13 June 2020

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13 June 2020

James D Brenton

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13 June 2020

Carlos Caldas

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13 June 2020

Charles Massie

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13 June 2020

Javier Garcia-Corbacho

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13 June 2020

Simon Pacey

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13 June 2020

Nitzan Rosenfeld

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13 June 2020

language of work or name

English

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publication date

24 February 2017

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9 September 2017

published in

Nature Reviews Cancer

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13 June 2020

volume

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13 June 2020

issue

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13 June 2020

page(s)

223-238

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Risk stratification of Barrett's oesophagus using a non-endoscopic sampling method coupled with a biomarker panel: a cohort study.

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21 January 2018

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21 January 2018

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Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence

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Identification of Circulating Tumor DNA for the Early Detection of Small-cell Lung Cancer

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MicroRNAs accurately identify cancer tissue origin

21 January 2018

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A Minimally-invasive Blood-derived Biomarker of Oligodendrocyte Cell-loss in Multiple Sclerosis

21 January 2018

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Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

21 January 2018

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Subclonal diversification of primary breast cancer revealed by multiregion sequencing

21 January 2018

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Metastasis as an evolutionary process

21 January 2018

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Heterogeneity Underlies the Emergence of EGFRT790 Wild-Type Clones Following Treatment of T790M-Positive Cancers with a Third-Generation EGFR Inhibitor

21 January 2018

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Establishing the origin of metastatic deposits in the setting of multiple primary malignancies: the role of massively parallel sequencing

21 January 2018

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Noninvasive detection of cancer-associated genome-wide hypomethylation and copy number aberrations by plasma DNA bisulfite sequencing

21 January 2018

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Spatial and temporal diversity in genomic instability processes defines lung cancer evolution

21 January 2018

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Intratumor heterogeneity in localized lung adenocarcinomas delineated by multiregion sequencing

21 January 2018

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Association Between Plasma Genotyping and Outcomes of Treatment With Osimertinib (AZD9291) in Advanced Non-Small-Cell Lung Cancer

21 January 2018

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Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients.

21 January 2018

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Circulating tumor DNA as an early marker of therapeutic response in patients with metastatic colorectal cancer

21 January 2018

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Circulating tumour DNA profiling reveals heterogeneity of EGFR inhibitor resistance mechanisms in lung cancer patients.

21 January 2018

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Association of EGFR L858R Mutation in Circulating Free DNA With Survival in the EURTAC Trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

ctDNA Determination of EGFR Mutation Status in European and Japanese Patients with Advanced NSCLC: The ASSESS Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

Gefitinib treatment in EGFR mutated caucasian NSCLC: circulating-free tumor DNA as a surrogate for determination of EGFR status

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

First-line gefitinib in Caucasian EGFR mutation-positive NSCLC patients: a phase-IV, open-label, single-arm study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

Monitoring of epidermal growth factor receptor tyrosine kinase inhibitor-sensitizing and resistance mutations in the plasma DNA of patients with advanced non-small cell lung cancer during treatment with erlotinib

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

Noninvasive detection of response and resistance in EGFR-mutant lung cancer using quantitative next-generation genotyping of cell-free plasma DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

EGFR mutation detection in ctDNA from NSCLC patient plasma: A cross-platform comparison of leading technologies to support the clinical development of AZD9291.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

Use of Liquid Biopsies in Clinical Oncology: Pilot Experience in 168 Patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

Establishment of tumor-specific copy number alterations from plasma DNA of patients with cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

Changes in colorectal carcinoma genomes under anti-EGFR therapy identified by whole-genome plasma DNA sequencing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

FAST-SeqS: a simple and efficient method for the detection of aneuploidy by massively parallel sequencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

Lengthening and shortening of plasma DNA in hepatocellular carcinoma patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

Plasma AR and abiraterone-resistant prostate cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

Bias-Corrected Targeted Next-Generation Sequencing for Rapid, Multiplexed Detection of Actionable Alterations in Cell-Free DNA from Advanced Lung Cancer Patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

Quantitative assessment of BRAF V600 mutant circulating cell-free tumor DNA as a tool for therapeutic monitoring in metastatic melanoma patients treated with BRAF/MEK inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

Early Prediction of Response to Tyrosine Kinase Inhibitors by Quantification of EGFR Mutations in Plasma of NSCLC Patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

Circulating Tumor DNA as an Early Indicator of Response to T-cell Transfer Immunotherapy in Metastatic Melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

Circulating tumor DNA analysis detects minimal residual disease and predicts recurrence in patients with stage II colon cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

Mutation tracking in circulating tumor DNA predicts relapse in early breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

Analysis of circulating tumour DNA to monitor disease burden following colorectal cancer surgery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

Serial monitoring of circulating tumor DNA in patients with primary breast cancer for detection of occult metastatic disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

Development of personalized tumor biomarkers using massively parallel sequencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

Use of cancer-specific genomic rearrangements to quantify disease burden in plasma from patients with solid tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

Acquired Resistance to the TRK Inhibitor Entrectinib in Colorectal Cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

Pros: Can tissue biopsy be replaced by liquid biopsy?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

Acquired EGFR C797S mutation mediates resistance to AZD9291 in non-small cell lung cancer harboring EGFR T790M.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

Tumor Heterogeneity and Lesion-Specific Response to Targeted Therapy in Colorectal Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

Characterizing the patterns of clonal selection in circulating tumor DNA from patients with colorectal cancer refractory to anti-EGFR treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

Distinct subclonal tumour responses to therapy revealed by circulating cell-free DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

Whole-genome plasma sequencing reveals focal amplifications as a driving force in metastatic prostate cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

Cellular barcoding: a technical appraisal.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

Circulating DNA as a Strong Multimarker Prognostic Tool for Metastatic Colorectal Cancer Patient Management Care

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

Changes in mutational status during third-line treatment for metastatic colorectal cancer--results of consecutive measurement of cell free DNA, KRAS and BRAF in the plasma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

Cell-free nucleic acids as biomarkers in cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

Co-occurrence of MYC amplification and TP53 mutations in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

Chip-based analysis of exosomal mRNA mediating drug resistance in glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

Clinical Applications of Circulating Tumor Cells and Circulating Tumor DNA as Liquid Biopsy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

RNA-Seq of Tumor-Educated Platelets Enables Blood-Based Pan-Cancer, Multiclass, and Molecular Pathway Cancer Diagnostics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

Circulating free DNA in plasma or serum as biomarker of carcinogenesis: practical aspects and biological significance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

21 January 2018

The cancer bloodhounds.

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

Sense and nonsense in the process of accreditation of a pathology laboratory

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

Multi-center evaluation of the novel fully-automated PCR-based Idylla™ BRAF Mutation Test on formalin-fixed paraffin-embedded tissue of malignant melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

BRAF Mutation Testing in Cell-Free DNA from the Plasma of Patients with Advanced Cancers Using a Rapid, Automated Molecular Diagnostics System

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

Nanopore sequencing detects structural variants in cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

Real-time, portable genome sequencing for Ebola surveillance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

Rapid Short-Read Sequencing and Aneuploidy Detection Using MinION Nanopore Technology

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

Real-time selective sequencing using nanopore technology

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

Circulating cell free DNA: Preanalytical considerations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

Comparison of cell stabilizing blood collection tubes for circulating plasma tumor DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

Comparative analysis of circulating tumor DNA stability In K3EDTA, Streck, and CellSave blood collection tubes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

Performance of Streck cfDNA Blood Collection Tubes for Liquid Biopsy Testing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

A stabilizing reagent prevents cell-free DNA contamination by cellular DNA in plasma during blood sample storage and shipping as determined by digital PCR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

Low Input Whole-Exome Sequencing to Determine the Representation of the Tumor Exome in Circulating DNA of Non-Small Cell Lung Cancer Patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

Detection of ultra-rare mutations by next-generation sequencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

Multiplex Detection of Rare Mutations by Picoliter Droplet Based Digital PCR: Sensitivity and Specificity Considerations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

Mutation profiling of tumor DNA from plasma and tumor tissue of colorectal cancer patients with a novel, high-sensitivity multiplexed mutation detection platform

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

Cellular Uptake of Deoxyribonucleic Acid by Human Tissue Culture Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

The value of serial plasma nuclear and mitochondrial DNA levels in patients with acute ischemic stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

Direct measurement of cell-free DNA from serially collected capillary plasma during incremental exercise

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

Prenatal DNA diagnosis of a single-gene disorder from maternal plasma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

Detection of K-ras mutation in sputum by mutant-allele-specific amplification (MASA)

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

Tumor-specific p53 sequences in blood and peritoneal fluid of women with epithelial ovarian cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

PCR-detection of tumor-derived p53 DNA in cerebrospinal fluid.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

Reversible acetylation on Lys501 regulates the activity of RNase II

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

Presymptomatic Identification of Cancers in Pregnant Women During Noninvasive Prenatal Testing

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

Comparison of KRAS mutation analysis of primary tumors and matched circulating cell-free DNA in plasmas of patients with colorectal cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

Guide to detecting epidermal growth factor receptor (EGFR) mutations in ctDNA of patients with advanced non-small-cell lung cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

Osimertinib or Platinum-Pemetrexed in EGFR T790M-Positive Lung Cancer.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

Osimertinib benefit in EGFR-mutant NSCLC patients with T790M-mutation detected by circulating tumour DNA.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

A pilot study evaluating concordance between blood-based and patient-matched tumor molecular testing within pancreatic cancer patients participating in the Know Your Tumor (KYT) initiative

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

Inferring expressed genes by whole-genome sequencing of plasma DNA.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

MinION Analysis and Reference Consortium: Phase 1 data release and analysis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

Higher amount of free circulating DNA in serum than in plasma is not mainly caused by contaminated extraneous DNA during separation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

Plasma collected from heparinized blood is not suitable for HCV-RNA detection by conventional RT-PCR assay

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

Changes in Concentration of DNA in Serum and Plasma during Storage of Blood Samples

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

The Effect of Preservative and Temperature on the Analysis of Circulating Tumor DNA.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.7

Exercise-induced increases in cell free DNA in human plasma originate predominantly from cells of the haematopoietic lineage

31 March 2020

1 reference

12 December 2020

Predominant hematopoietic origin of cell-free DNA in plasma and serum after sex-mismatched bone marrow transplantation

1 reference

12 December 2020

Circulating cell-free DNA has a high degree of specificity to detect exon 19 deletions and the single-point substitution mutation L858R in non-small cell lung cancer

1 reference

12 December 2020

The clearance and localization of nucleic acids by New Zealand and normal mice

1 reference

12 December 2020

Detection of microsatellite alterations in plasma DNA of non-small cell lung cancer patients: a prospect for early diagnosis

1 reference

12 December 2020

Free DNA in the serum of cancer patients and the effect of therapy.

1 reference

12 December 2020

Measurement of deoxyribonuclease I activity in human tissues and body fluids by a single radial enzyme-diffusion method

1 reference

12 December 2020

Detection rate of actionable mutations in diverse cancers using a biopsy-free (blood) circulating tumor cell DNA assay

1 reference

12 December 2020

Detection of K-ras mutations in the stool of patients with pancreatic adenocarcinoma and pancreatic ductal hyperplasia

1 reference

12 December 2020

DNA fragments in the blood plasma of cancer patients: quantitations and evidence for their origin from apoptotic and necrotic cells.

1 reference

12 December 2020

Genetic analysis of DNA excreted in urine: a new approach for detecting specific genomic DNA sequences from cells dying in an organism.

1 reference

12 December 2020

Soluble normal and mutated DNA sequences from single-copy genes in human blood

1 reference

12 December 2020

Rapid clearance of plasma Epstein-Barr virus DNA after surgical treatment of nasopharyngeal carcinoma

1 reference

12 December 2020

1 reference

12 December 2020

Cell-free DNA in human blood plasma: length measurements in patients with pancreatic cancer and healthy controls

1 reference

12 December 2020

Optimised Pre-Analytical Methods Improve KRAS Mutation Detection in Circulating Tumour DNA (ctDNA) from Patients with Non-Small Cell Lung Cancer (NSCLC)

1 reference

12 December 2020

Elimination of unaltered DNA in mixed clinical samples via nuclease-assisted minor-allele enrichment

1 reference

12 December 2020

Detection of oncogene mutations in sputum precedes diagnosis of lung cancer.

1 reference

12 December 2020

Circulating tumor DNA to monitor treatment response and detect acquired resistance in patients with metastatic melanoma

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRC.2017.7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28233803%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28233803%20AND%20SRC:MED&resulttype=core&format=json