Inhibition of monocarboxylate transporter-4 depletes stem-like glioblastoma cells and inhibits HIF transcriptional response in a lactate-independent manner (Q39090175)

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scientific article published on 30 September 2013

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English	Inhibition of monocarboxylate transporter-4 depletes stem-like glioblastoma cells and inhibits HIF transcriptional response in a lactate-independent manner	scientific article published on 30 September 2013

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scholarly article

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Europe PubMed Central

PMC publication ID

9 September 2017

Inhibition of monocarboxylate transporter-4 depletes stem-like glioblastoma cells and inhibits HIF transcriptional response in a lactate-independent manner (English)

1 reference

Europe PubMed Central

PMC publication ID

9 September 2017

1 reference

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K S Lim

1

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Europe PubMed Central

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9 September 2017

K J Lim

2

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Europe PubMed Central

PMC publication ID

9 September 2017

A C Price

3

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Europe PubMed Central

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9 September 2017

B A Orr

4

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Europe PubMed Central

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9 September 2017

C G Eberhart

5

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Europe PubMed Central

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9 September 2017

E E Bar

6

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9 September 2017

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publication date

30 September 2013

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Europe PubMed Central

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9 September 2017

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Europe PubMed Central

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9 September 2017

33

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Europe PubMed Central

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9 September 2017

35

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Europe PubMed Central

PMC publication ID

9 September 2017

4433-4441

1 reference

Europe PubMed Central

PMC publication ID

9 September 2017

HIF-1α up-regulates NDRG1 expression through binding to NDRG1 promoter, leading to proliferation of lung cancer A549 cells

1 reference

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Monocarboxylate transporters (MCTs) in gliomas: expression and exploitation as therapeutic targets

1 reference

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FoxM1 and Wnt/β-catenin signaling in glioma stem cells

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Wnt/beta-catenin signaling in glioma

1 reference

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Culture of human mesenchymal stem cells at low oxygen tension improves growth and genetic stability by activating glycolysis

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CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors

1 reference

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Non-canonical HIF-2α function drives autonomous breast cancer cell growth via an AREG-EGFR/ErbB4 autocrine loop.

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Metabolic alterations in highly tumorigenic glioblastoma cells: preference for hypoxia and high dependency on glycolysis

1 reference

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Metabolic targeting of lactate efflux by malignant glioma inhibits invasiveness and induces necrosis: an in vivo study

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In vivo pH in metabolic-defective Ras-transformed fibroblast tumors: key role of the monocarboxylate transporter, MCT4, for inducing an alkaline intracellular pH.

1 reference

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Notch signaling contributes to the maintenance of both normal neural stem cells and patient-derived glioma stem cells

1 reference

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Glioblastoma, cancer stem cells and hypoxia

1 reference

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Hypoxia increases the expression of stem-cell markers and promotes clonogenicity in glioblastoma neurospheres

1 reference

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Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1

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Hypoxia inducible factors in cancer stem cells

1 reference

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The lysyl oxidases LOX and LOXL2 are necessary and sufficient to repress E-cadherin in hypoxia: insights into cellular transformation processes mediated by HIF-1

1 reference

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NOTCH pathway blockade depletes CD133-positive glioblastoma cells and inhibits growth of tumor neurospheres and xenografts

1 reference

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The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype

1 reference

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Oxygen and Cell Fate Decisions.

1 reference

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Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells

1 reference

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Quantitative metrics of net proliferation and invasion link biological aggressiveness assessed by MRI with hypoxia assessed by FMISO-PET in newly diagnosed glioblastomas

1 reference

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Identification of oxygen-sensitive transcriptional programs in human embryonic stem cells

1 reference

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Notch activation promotes cell proliferation and the formation of neural stem cell-like colonies in human glioma cells

1 reference

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Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma

1 reference

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HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity

1 reference

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Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors

1 reference

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The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism.

1 reference

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Silencing of monocarboxylate transporters via small interfering ribonucleic acid inhibits glycolysis and induces cell death in malignant glioma: an in vitro study

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Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma

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Green fluorescent protein is a suitable reporter of tumor hypoxia despite an oxygen requirement for chromophore formation

1 reference

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Expression of monocarboxylate transporter MCT1 in normal and neoplastic human CNS tissues

1 reference

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Characterisation of human monocarboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscle

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CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression

1 reference

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A hypoxic niche regulates glioblastoma stem cells through hypoxia inducible factor 2 alpha

1 reference

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miR-124 is frequently down-regulated in medulloblastoma and is a negative regulator of SLC16A1.

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31 March 2020

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10.1038/ONC.2013.390

1 reference

Europe PubMed Central

PMC publication ID

9 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

9 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

9 September 2017

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