Drug-Mediated Regulation of Glycosaminoglycan Biosynthesis (Q39060517)

Recent advances in the structural study of functional chondroitin sulfate and dermatan sulfate in health and disease

21 January 2018

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Fell-Muir Lecture: Heparan sulphate and the art of cell regulation: a polymer chain conducts the protein orchestra

21 January 2018

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Heparan sulfate proteoglycan as a cell-surface endocytosis receptor

21 January 2018

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Glycosaminoglycans in infectious disease

21 January 2018

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Fell-Muir Lecture: Proteoglycans and more--from molecules to biology

21 January 2018

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Demystifying heparan sulfate-protein interactions.

21 January 2018

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Functions of cell surface heparan sulfate proteoglycans

21 January 2018

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Structure, metabolism, and tissue roles of chondroitin sulfate proteoglycans

21 January 2018

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Order out of chaos: assembly of ligand binding sites in heparan sulfate

21 January 2018

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Recent advances in the structural biology of chondroitin sulfate and dermatan sulfate

21 January 2018

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Pathophysiology of heparan sulphate: many diseases, few drugs

21 January 2018

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Proteoglycan synthesis and Golgi organization in polarized epithelial cells.

21 January 2018

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Heparan sulfate biosynthesis enzymes EXT1 and EXT2 affect NDST1 expression and heparan sulfate sulfation

21 January 2018

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Enzyme interactions in heparan sulfate biosynthesis: uronosyl 5-epimerase and 2-O-sulfotransferase interact in vivo

21 January 2018

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C5-epimerase and 2-O-sulfotransferase associate in vitro to generate contiguous epimerized and 2-O-sulfated heparan sulfate domains

21 January 2018

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'Immunosequencing' of heparan sulfate from human cell lines and rat kidney: the (GlcNS6S-IdoA2S)₃ motif, recognized by antibody NS4F5, is located towards the non-reducing end.

21 January 2018

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3-O-sulfated oligosaccharide structures are recognized by anti-heparan sulfate antibody HS4C3.

21 January 2018

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Characterization of anti-heparan sulfate phage display antibodies AO4B08 and HS4E4.

21 January 2018

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Interactions between heparan sulfate and proteins-design and functional implications

21 January 2018

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Intracellular lectins involved in folding and transport in the endoplasmic reticulum.

21 January 2018

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Human genetic disorders and knockout mice deficient in glycosaminoglycan

21 January 2018

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Glycan antagonists and inhibitors: a fount for drug discovery

21 January 2018

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Drugs affecting glycosaminoglycan metabolism

21 January 2018

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Developing inhibitors of glycan processing enzymes as tools for enabling glycobiology.

21 January 2018

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Transporters of nucleotide sugars, ATP, and nucleotide sulfate in the endoplasmic reticulum and Golgi apparatus

21 January 2018

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The dynamic metabolism of hyaluronan regulates the cytosolic concentration of UDP-GlcNAc.

21 January 2018

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The role of nucleotide sugar transporters in development of eukaryotes

21 January 2018

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Structure and function of nucleotide sugar transporters: Current progress

21 January 2018

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UDP-galactose (SLC35A2) and UDP-N-acetylglucosamine (SLC35A3) Transporters Form Glycosylation-related Complexes with Mannoside Acetylglucosaminyltransferases (Mgats).

21 January 2018

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Molecular cloning and characterization of a novel 3'-phosphoadenosine 5'-phosphosulfate transporter, PAPST2.

21 January 2018

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Overexpression of the 3'-phosphoadenosine 5'-phosphosulfate (PAPS) transporter 1 increases sulfation of chondroitin sulfate in the apical pathway of MDCK II cells.

21 January 2018

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Human xylosyltransferases in health and disease

21 January 2018

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FAM20B is a kinase that phosphorylates xylose in the glycosaminoglycan-protein linkage region

21 January 2018

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Phosphorylation and sulfation of oligosaccharide substrates critically influence the activity of human beta1,4-galactosyltransferase 7 (GalT-I) and beta1,3-glucuronosyltransferase I (GlcAT-I) involved in the biosynthesis of the glycosaminoglycan-pro

21 January 2018

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GlcUAβ1-3Galβ1-3Galβ1-4Xyl(2-O-phosphate) is the preferred substrate for chondroitin N-acetylgalactosaminyltransferase-1.

21 January 2018

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Identification of phosphatase that dephosphorylates xylose in the glycosaminoglycan-protein linkage region of proteoglycans

21 January 2018

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EXTL2, a member of the EXT family of tumor suppressors, controls glycosaminoglycan biosynthesis in a xylose kinase-dependent manner

21 January 2018

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Xylose phosphorylation functions as a molecular switch to regulate proteoglycan biosynthesis

21 January 2018

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The putative tumor suppressors EXT1 and EXT2 are glycosyltransferases required for the biosynthesis of heparan sulfate

21 January 2018

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Heparin/heparan sulfate biosynthesis: processive formation of N-sulfated domains

21 January 2018

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Glucuronyl C5-epimerase an enzyme converting glucuronic acid to iduronic acid in heparan sulfate/heparin biosynthesis

21 January 2018

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Heparan Sulfate: Biosynthesis, Structure, and Function.

21 January 2018

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Biosynthesis and function of chondroitin sulfate

21 January 2018

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Iduronic acid in chondroitin/dermatan sulfate: biosynthesis and biological function

21 January 2018

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Iduronic acid in chondroitin/dermatan sulfate affects directional migration of aortic smooth muscle cells

21 January 2018

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Two dermatan sulfate epimerases form iduronic acid domains in dermatan sulfate.

21 January 2018

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Dermatan 4-O-sulfotransferase 1 is pivotal in the formation of iduronic acid blocks in dermatan sulfate

21 January 2018

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Keratan sulfate: an up-to-date review

21 January 2018

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Keratan sulfate biosynthesis

21 January 2018

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Molecular cloning and characterization of human keratan sulfate Gal-6-sulfotransferase

21 January 2018

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KSGal6ST is essential for the 6-sulfation of galactose within keratan sulfate in early postnatal brain

21 January 2018

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Purification and characterization of N-acetylglucosaminyl sulfotransferase from chick corneas

21 January 2018

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N-acetylglucosamine 6-O-sulfotransferase-1-deficient mice show better functional recovery after spinal cord injury.

21 January 2018

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21 January 2018

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Tissue distribution and subcellular localization of hyaluronan synthase isoenzymes

21 January 2018

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Hyaluronan: genetic insights into the complex biology of a simple polysaccharide

21 January 2018

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Transcriptional and post-translational regulation of hyaluronan synthesis.

21 January 2018

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The activity of hyaluronan synthase 2 is regulated by dimerization and ubiquitination

21 January 2018

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Role of UDP-N-acetylglucosamine (GlcNAc) and O-GlcNAcylation of hyaluronan synthase 2 in the control of chondroitin sulfate and hyaluronan synthesis

21 January 2018

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Influence of core protein sequence on glycosaminoglycan assembly

21 January 2018

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Decorin core protein secretion is regulated by N-linked oligosaccharide and glycosaminoglycan additions

21 January 2018

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Biosynthesis of chondroitin/dermatan sulfate

21 January 2018

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Glycosaminoglycan Chains Affect Exocytic and Endocytic Protein Traffic

21 January 2018

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Uncoupling of chondroitin sulfate glycosaminoglycan synthesis by brefeldin A.

21 January 2018

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The biosynthesis of chondroitin-sulfate protein complex

21 January 2018

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The role of extracellular materials in cell movement. I. Inhibition of mucopolysaccharide synthesis does not stop ruffling membrane activity or cell movement

21 January 2018

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Comparative enzymology of the adenosine triphosphate sulphurylases from leaf tissue of selenium-accumulator and non-accumulator plants

21 January 2018

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Modulation of cell surface heparan sulfate structure by growth of cells in the presence of chlorate

21 January 2018

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Inhibition of hyaluronan synthesis in Streptococcus equi FM100 by 4-methylumbelliferone

21 January 2018

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A novel mechanism for the inhibition of hyaluronan biosynthesis by 4-methylumbelliferone

21 January 2018

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4-Methylumbelliferone inhibits hyaluronan synthesis by depletion of cellular UDP-glucuronic acid and downregulation of hyaluronan synthase 2 and 3.

21 January 2018

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Inhibition of hyaluronan synthesis in rats reduces renal ability to excrete fluid and electrolytes during acute hydration.

21 January 2018

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An inhibitor of the human UDP-GlcNAc 4-epimerase identified from a uridine-based library: a strategy to inhibit O-linked glycosylation

21 January 2018

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Identification of novel inhibitors of UDP-Glc 4'-epimerase, a validated drug target for african sleeping sickness.

21 January 2018

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Synthesis of 4-deoxy analogues of 2-acetamido-2-deoxy-D-glucose and 2-acetamido-2-deoxy-D-xylose and their effects on glycoconjugate biosynthesis

21 January 2018

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Synthesis of 4-deoxy-4-fluoro analogues of 2-acetamido-2-deoxy-D-glucose and 2-acetamido-2-deoxy-D-galactose and their effects on cellular glycosaminoglycan biosynthesis

21 January 2018

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Novel Glycosaminoglycan Precursors as Anti-Amyloid Agents, Part III

21 January 2018

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Synthesis and biological evaluation of a radiolabeled analog of methyl 2-acetamido-2,4-dideoxy-beta-D-xylo-hexopyranoside directed towards influencing cellular glycosaminoglycan biosynthesis

21 January 2018

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Interfering with UDP-GlcNAc metabolism and heparan sulfate expression using a sugar analogue reduces angiogenesis

21 January 2018

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Heparan sulphate proteoglycans in Alzheimer's disease and amyloid-related disorders

21 January 2018

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Novel glycosaminoglycan precursors as anti-amyloid agents part II.

21 January 2018

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Novel glycosaminoglycan precursors as antiamyloid agents: Part IV.

21 January 2018

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Inhibition of glycosaminoglycan synthesis and protein glycosylation with WAS-406 and azaserine result in reduced islet amyloid formation in vitro

21 January 2018

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Regulation of heparan sulfate and chondroitin sulfate glycosaminoglycan biosynthesis by 4-fluoro-glucosamine in murine airway smooth muscle cells

21 January 2018

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A 4-deoxy analogue of N-acetyl-D-glucosamine inhibits heparan sulphate expression and growth factor binding in vitro

21 January 2018

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Separation and characterization of chondroitin 6-sulfotransferase and chondroitin 4-sulfotransferase from chick embryo cartilage

21 January 2018

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Regulation of serum glycosaminoglycan sulfotransferase activities: inhibition by sulfated glycosaminoglycans and activation by polyamines and basic peptides including a polylysine-containing segment of the c-Ki-ras 2 protein

21 January 2018

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Inhibitory peptides of the sulfotransferase domain of the heparan sulfate enzyme, N-deacetylase-N-sulfotransferase-1.

21 January 2018

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Sulfotransferase structural biology and inhibitor discovery

21 January 2018

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Strategies for drug discovery by targeting sulfation pathways

21 January 2018

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Understanding the substrate specificity of the heparan sulfate sulfotransferases by an integrated biosynthetic and crystallographic approach

21 January 2018

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Discovery of Carbohydrate Sulfotransferase Inhibitors from a Kinase-Directed Library We thank Sharon Long and Dave Keating for providing both the NodH sulfotransferase and APS Kinase during our preliminary experiments and Jack Kirsch for [...]

21 January 2018

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Tyrosylprotein sulfotransferase inhibitors generated by combinatorial target-guided ligand assembly

21 January 2018

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Discovery of estrogen sulfotransferase inhibitors from a purine library screen

21 January 2018

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A library approach to the generation of bisubstrate analogue sulfotransferase inhibitors

21 January 2018

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Inhibition of N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase by beta-D-4-O-sulfo-N-acetylgalactosaminides bearing various hydrophobic aglycons.

21 January 2018

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Synthesis and biological evaluation of gem-diamine 1-N-iminosugars related to L-iduronic acid as inhibitors of heparan sulfate 2-O-sulfotransferase

21 January 2018

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The effect of D-xylose, β-D-xylosides and β-D-galactosides on chondroitin sulphate biosynthesis in embryonic chicken cartilage

21 January 2018

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Stimulation of synthesis of free chondroitin sulfate chains by beta-D-xylosides in cultured cells

21 January 2018

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beta-D-xylosides and their analogues as artificial initiators of glycosaminoglycan chain synthesis. Aglycone-related variation in their effectiveness in vitro and in ovo

21 January 2018

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Glycoside primers of Psittacanthus cucullaris

21 January 2018

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Primers of glycosaminoglycan biosynthesis from Peruvian rain forest plants

21 January 2018

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Tumor attenuation by combined heparan sulfate and polyamine depletion.

21 January 2018

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"Click" xylosides initiate glycosaminoglycan biosynthesis in a mammalian cell line

21 January 2018

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Investigating the elusive mechanism of glycosaminoglycan biosynthesis

21 January 2018

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Inhibition of heparan sulfate and chondroitin sulfate proteoglycan biosynthesis

21 January 2018

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Novel glycosaminoglycan biosynthetic inhibitors affect tumor-associated angiogenesis

21 January 2018

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Synthesis and biology of oligoethylene glycol linked naphthoxylosides

21 January 2018

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Exploration of the active site of β4GalT7: modifications of the aglycon of aromatic xylosides.

21 January 2018

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RGD-xyloside conjugates prime glycosaminoglycans

21 January 2018

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A New C-Xyloside induces modifications of GAG expression, structure and functional properties

21 January 2018

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Exogenous addition of a C-xylopyranoside derivative stimulates keratinocyte dermatan sulfate synthesis and promotes migration

21 January 2018

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FGF-10 and specific structural elements of dermatan sulfate size and sulfation promote maximal keratinocyte migration and cellular proliferation

21 January 2018

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Diethylcarbamazine, antifilarial drug, inhibits microtubule polymerization and disrupts preformed microtubules

21 January 2018

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Organizational interplay of Golgi N-glycosyltransferases involves organelle microenvironment-dependent transitions between enzyme homo- and heteromers

21 January 2018

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Anti-inflammatory effects of diethylcarbamazine: a review

21 January 2018

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Weak bases and ionophores rapidly and reversibly raise the pH of endocytic vesicles in cultured mouse fibroblasts

21 January 2018

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Monensin inhibits synthesis of proteoglycan, but not of hyaluronate, in chondrocytes

21 January 2018

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Brefeldin A: deciphering an enigmatic inhibitor of secretion

21 January 2018

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Effects of cyclofenil diphenol, an agent which disrupts Golgi structure, on proteoglycan synthesis in chondrocytes

21 January 2018

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Selective inhibition of proteoglycan and hyaluronate synthesis in chondrocyte cultures by cyclofenil diphenol, a non-steroidal weak oestrogen

21 January 2018

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Effects of flavonoids on glycosaminoglycan synthesis: implications for substrate reduction therapy in Sanfilippo disease and other mucopolysaccharidoses

21 January 2018

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Genistein-mediated inhibition of glycosaminoglycan synthesis as a basis for gene expression-targeted isoflavone therapy for mucopolysaccharidoses

21 January 2018

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Storage correction in cells of patients suffering from mucopolysaccharidoses types IIIA and VII after treatment with genistein and other isoflavones

21 January 2018

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Genistein increases glycosaminoglycan levels in mucopolysaccharidosis type I cell models

21 January 2018

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Genistein reduces glycosaminoglycan levels in a mouse model of mucopolysaccharidosis type II

21 January 2018

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Genistein reduces lysosomal storage in peripheral tissues of mucopolysaccharide IIIB mice

21 January 2018

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Genistein improves neuropathology and corrects behaviour in a mouse model of neurodegenerative metabolic disease

21 January 2018

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Adverse Effects of Genistein in a Mucopolysaccharidosis Type I Mouse Model

21 January 2018

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The use of elevated doses of genistein-rich soy extract in the gene expression-targeted isoflavone therapy for Sanfilippo disease patients

21 January 2018

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Genistein supplementation in patients affected by Sanfilippo disease

21 January 2018

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Synthetic genistein derivatives as modulators of glycosaminoglycan storage

21 January 2018

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Genistein--a dietary compound inducing hormonal and metabolic changes

21 January 2018

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The phytoestrogen genistein modulates lysosomal metabolism and transcription factor EB (TFEB) activation

21 January 2018

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Modulation of expression of genes involved in glycosaminoglycan metabolism and lysosome biogenesis by flavonoids

21 January 2018

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Rhodamine B inhibition of glycosaminoglycan production by cultured human lip fibroblasts.

21 January 2018

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Rhodamine B and 2-acetamido-1,3,6-tri-O-acetyl-4-deoxy-4-fluoro-D-glucopyranose (F-GlcNAc) inhibit chondroitin/dermatan and keratan sulphate synthesis by different mechanisms in bovine chondrocytes

21 January 2018

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Inhibition of glycosaminoglycan synthesis using rhodamine B in a mouse model of mucopolysaccharidosis type IIIA.

21 January 2018

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Improvement in behaviour after substrate deprivation therapy with rhodamine B in a mouse model of MPS IIIA.

21 January 2018

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BIOCHEMICAL PROPERTIES OF ANTI-INFLAMMATORY DRUGS-II. SOME EFFECTS ON SULPHATE-35S METABOLISM IN VIVO.

21 January 2018

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Studies on the mechanism of action of salicylates. VII. Effect of a few anti-inflammatory agents on uridine-5'-diphosphoglucose dehydrogenase

21 January 2018

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Studies on mechanism of action of salicylates. V. Effect of salicylic acid on enzymes involved in mucopolysaccharides synthesis.

21 January 2018

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Effect of anti-inflammatory drugs on sulphated glycosaminoglycan synthesis in aged human articular cartilage

21 January 2018

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Studies on the metabolism of glycosaminoglycans under the influence of new herbal anti-inflammatory agents

21 January 2018

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Effect of non-steroidal anti-inflammatory drugs on the course of osteoarthritis

21 January 2018

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Is there an association between the use of different types of nonsteroidal antiinflammatory drugs and radiologic progression of osteoarthritis? The Rotterdam Study

21 January 2018

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Effects of tenoxicam and aspirin on the metabolism of proteoglycans and hyaluronan in normal and osteoarthritic human articular cartilage

21 January 2018

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Effects of meloxicam, compared with other NSAIDs, on cartilage proteoglycan metabolism, synovial prostaglandin E2, and production of interleukins 1, 6 and 8, in human and porcine explants in organ culture.

21 January 2018

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Effects of diclofenac, aceclofenac and meloxicam on the metabolism of proteoglycans and hyaluronan in osteoarthritic human cartilage

21 January 2018

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Differential direct effects of cyclo-oxygenase-1/2 inhibition on proteoglycan turnover of human osteoarthritic cartilage: an in vitro study

21 January 2018

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The chondroprotective effect of selective COX-2 inhibition in osteoarthritis: ex vivo evaluation of human cartilage tissue after in vivo treatment

21 January 2018

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Morphologic and biochemical changes in articular cartilages of immature beagle dogs dosed with difloxacin

21 January 2018

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The effects of levofloxacin on rabbit fibroblast-like synoviocytes in vitro

21 January 2018

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The effect of enrofloxacin on cell proliferation and proteoglycans in horse tendon cells

21 January 2018

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The effects of enrofloxacin on decorin and glycosaminoglycans in avian tendon cell cultures

21 January 2018

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Differential effects of gemfibrozil on migration, proliferation and proteoglycan production in human vascular smooth muscle cells.

21 January 2018

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Fenofibrate modifies human vascular smooth muscle proteoglycans and reduces lipoprotein binding

21 January 2018

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Thiazolidinediones reduce the LDL binding affinity of non-human primate vascular cell proteoglycans

21 January 2018

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Agonists of peroxisome proliferators-activated receptors (PPAR) alpha, beta/delta or gamma reduce transforming growth factor (TGF)-beta-induced proteoglycans' production in chondrocytes

21 January 2018

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Regulation of the atherogenic properties of vascular smooth muscle proteoglycans by oral anti-hyperglycemic agents.

21 January 2018

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Effect of calcium channel blockers on proteoglycan synthesis by vascular smooth muscle cells and low density lipoprotein--proteoglycan interaction

21 January 2018

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A clinical review of drug-induced gingival overgrowths

21 January 2018

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Nifedipine-induced gingival hyperplasia. A histochemical and ultrastructural study.

21 January 2018

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Statin-exposed vascular smooth muscle cells secrete proteoglycans with decreased binding affinity for LDL.

21 January 2018

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Dimethyl sulfoxide affects colony morphology on agar and alters distribution of glycosaminoglycans and fibronectin

21 January 2018

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Effect of dimethylsulfoxide on the proliferation and glycosaminoglycan synthesis of rat prostate adenocarcinoma cells (PAIII) in vitro: isolation and characterization of DMSO-resistant cells.

21 January 2018

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Multidisciplinary utilization of dimethyl sulfoxide: pharmacological, cellular, and molecular aspects

21 January 2018

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Diphenylhydantoin (dilantin) gingival hyperplasia: drug-induced abnormality of connective tissue

21 January 2018

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The pathogenesis of drug-induced gingival overgrowth

21 January 2018

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Stimulation of collagen and glycosaminoglycan production by phenytoin 5,5-diphenylhydantoin in monolayer cultures of mesenchymal cells derived from embryonic chick sternae.

21 January 2018

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The clinical effect of topical phenytoin on wound healing: a systematic review

21 January 2018

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Pathogenesis of drug-induced gingival overgrowth. A review of studies in the rat model

21 January 2018

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Role of heparan sulfate in sexually transmitted infections

21 January 2018

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Molecular interactions between chondroitin-dermatan sulfate and growth factors/receptors/matrix proteins

21 January 2018

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Sulfated sugars in the extracellular matrix orchestrate ovarian cancer development: 'when sweet turns sour'.

21 January 2018

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Sulfated glycans in inflammation

21 January 2018

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Glycosaminoglycans and their proteoglycans: host-associated molecular patterns for initiation and modulation of inflammation

21 January 2018

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Predicting targeted polypharmacology for drug repositioning and multi- target drug discovery

21 January 2018

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Polypharmacology: drug discovery for the future

21 January 2018

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Polypharmacology: challenges and opportunities in drug discovery

21 January 2018

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Shifting from the single to the multitarget paradigm in drug discovery

21 January 2018

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The influence of drug-like concepts on decision-making in medicinal chemistry

21 January 2018

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A guide to drug discovery: Target selection in drug discovery

21 January 2018

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The human D-glucuronyl C5-epimerase gene is transcriptionally activated through the beta-catenin-TCF4 pathway

21 January 2018

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D-glucuronyl C5-epimerase acts in dorso-ventral axis formation in zebrafish

21 January 2018

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Clinical development success rates for investigational drugs

21 January 2018

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Trends in the exploitation of novel drug targets

21 January 2018

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How many drug targets are there?

21 January 2018

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Exploring the biologically relevant chemical space for drug discovery.

21 January 2018

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Selective optimization of side activities: another way for drug discovery

21 January 2018

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Drug repurposing: far beyond new targets for old drugs.

21 January 2018

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New horizons for old drugs and drug leads

21 January 2018

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The 4-quinolone-3-carboxylic acid motif as a multivalent scaffold in medicinal chemistry

21 January 2018

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