Generation of genetically-modified human differentiated cells for toxicological tests and the study of neurodegenerative diseases. (Q39068725)

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28 February 2020

title

Generation of genetically-modified human differentiated cells for toxicological tests and the study of neurodegenerative diseases (English)

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28 February 2020

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28 February 2020

Stefan Schildknecht

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28 February 2020

Christiaan Karreman

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28 February 2020

Dominik Pöltl

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28 February 2020

Liudmila Efrémova

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28 February 2020

Cornelius Kullmann

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28 February 2020

Simon Gutbier

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28 February 2020

Anne Krug

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28 February 2020

Diana Scholz

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28 February 2020

Hanne R Gerding

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28 February 2020

publication date

1 January 2013

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ALTEX: Alternatives to Animal Experimentation

28 February 2020

published in

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28 February 2020

volume

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28 February 2020

issue

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28 February 2020

page(s)

427-444

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describes a project that uses

28 February 2020

LUHMES

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cites work

A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing - t4 report*.

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15 October 2024

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Food for thought... on the real success of 3R approaches

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Impaired mitochondrial dynamics and function in the pathogenesis of Parkinson's disease

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Coordinated waves of gene expression during neuronal differentiation of embryonic stem cells as basis for novel approaches to developmental neurotoxicity testing

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RNA interference-mediated knockdown of alpha-synuclein protects human dopaminergic neuroblastoma cells from MPP(+) toxicity and reduces dopamine transport.

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15 October 2024

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Sensitivity of dopaminergic neuron differentiation from stem cells to chronic low-dose methylmercury exposure

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Defined inflammatory states in astrocyte cultures: correlation with susceptibility towards CD95-driven apoptosis

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Wallerian degeneration of injured axons and synapses is delayed by a Ube4b/Nmnat chimeric gene.

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Targeting NMNAT1 to axons and synapses transforms its neuroprotective potency in vivo.

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Astroglial cells provide a template for the positioning of developing cerebellar neurons in vitro

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Deletion of the alpha-synuclein locus in a subpopulation of C57BL/6J inbred mice

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Vesicular monoamine transporter 2 regulates the sensitivity of rat dopaminergic neurons to disturbed cytosolic dopamine levels.

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15 October 2024

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Ubiquitin-fusion protein system: a powerful tool for ectopic protein expression in mammalian cells.

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Neuronal regulation of astroglial morphology and proliferation in vitro

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Additive Effects of Caspase Inhibitor and Lazaroid on the Survival of Transplanted Rat and Human Embryonic Dopamine Neurons

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15 October 2024

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Tyrosine hydroxylase expression is unstable in a human immortalized mesencephalic cell line--studies in vitro and after intracerebral grafting in vivo

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15 October 2024

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Reduced immunoproteasome formation and accumulation of immunoproteasomal precursors in the brains of lymphocytic choriomeningitis virus-infected mice

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15 October 2024

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A new versatile and compact lentiviral vector.

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Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells

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15 October 2024

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Oxidative and nitrative alpha-synuclein modifications and proteostatic stress: implications for disease mechanisms and interventions in synucleinopathies.

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15 October 2024

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A segment of the 5' nontranslated region of encephalomyocarditis virus RNA directs internal entry of ribosomes during in vitro translation

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15 October 2024

https://opencitations.net/index/api/v1/references/10.14573/ALTEX.2013.4.427

Requirement of a dopaminergic neuronal phenotype for toxicity of low concentrations of 1-methyl-4-phenylpyridinium to human cells

1 reference

15 October 2024

https://opencitations.net/index/api/v1/references/10.14573/ALTEX.2013.4.427

Analysis of the aphthovirus 2A/2B polyprotein ‘cleavage’ mechanism indicates not a proteolytic reaction, but a novel translational effect: a putative ribosomal ‘skip’

1 reference

15 October 2024

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Botulinum neurotoxin C initiates two different programs for neurite degeneration and neuronal apoptosis

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15 October 2024

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An 85-kb tandem triplication in the slow Wallerian degeneration (Wlds) mouse

1 reference

15 October 2024

https://opencitations.net/index/api/v1/references/10.14573/ALTEX.2013.4.427

Increased sensitivity to MPTP in human alpha-synuclein A30P transgenic mice.

1 reference

15 October 2024

https://opencitations.net/index/api/v1/references/10.14573/ALTEX.2013.4.427

Neural stem cells in the adult human brain

1 reference

15 October 2024

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Food for thought ... considerations and guidelines for basic test method descriptions in toxicology

2 references

15 October 2024

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15 October 2024

https://opencitations.net/index/api/v1/citations/10.14573/ALTEX.2010.4.309

Effect of the overexpression of wild-type or mutant alpha-synuclein on cell susceptibility to insult

1 reference

15 October 2024

https://opencitations.net/index/api/v1/references/10.14573/ALTEX.2013.4.427

Comparison between proliferative and neuron-like SH-SY5Y cells as an in vitro model for Parkinson disease studies

1 reference

15 October 2024

https://opencitations.net/index/api/v1/references/10.14573/ALTEX.2013.4.427

Control of Aβ release from human neurons by differentiation status and RET signaling

1 reference

15 October 2024

https://opencitations.net/index/api/v1/references/10.14573/ALTEX.2013.4.427

Translating neurobehavioural endpoints of developmental neurotoxicity tests into in vitro assays and readouts

1 reference

15 October 2024

https://opencitations.net/index/api/v1/references/10.14573/ALTEX.2013.4.427

Expression of mutant alpha-synucleins enhances dopamine transporter-mediated MPP+ toxicity in vitro

1 reference

15 October 2024

https://opencitations.net/index/api/v1/references/10.14573/ALTEX.2013.4.427

Neuroprotection by minocycline caused by direct and specific scavenging of peroxynitrite

1 reference

15 October 2024

https://opencitations.net/index/api/v1/references/10.14573/ALTEX.2013.4.427

Sensitivity to MPTP is not increased in Parkinson's disease-associated mutant alpha-synuclein transgenic mice

1 reference

15 October 2024

https://opencitations.net/index/api/v1/references/10.14573/ALTEX.2013.4.427

Derivation of neural crest cells from human pluripotent stem cells.

1 reference

15 October 2024

https://opencitations.net/index/api/v1/references/10.14573/ALTEX.2013.4.427

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor

1 reference

15 October 2024

https://opencitations.net/index/api/v1/references/10.14573/ALTEX.2013.4.427

Free radical scavengers protect dopaminergic cell lines from apoptosis induced by complex I inhibitors

1 reference

15 October 2024

https://opencitations.net/index/api/v1/references/10.14573/ALTEX.2013.4.427

Effect of mutant alpha-synuclein on dopamine homeostasis in a new human mesencephalic cell line

1 reference

15 October 2024

https://opencitations.net/index/api/v1/references/10.14573/ALTEX.2013.4.427

Assessment of chemical-induced impairment of human neurite outgrowth by multiparametric live cell imaging in high-density cultures

1 reference

15 October 2024

https://opencitations.net/index/api/v1/references/10.14573/ALTEX.2013.4.427

Retinoic acid-induced differentiation of cultured human neuroblastoma cells: a comparison with phorbolester-induced differentiation

1 reference

15 October 2024

https://opencitations.net/index/api/v1/references/10.14573/ALTEX.2013.4.427

Overexpression of Parkinson's disease-associated alpha-synucleinA53T by recombinant adeno-associated virus in mice does not increase the vulnerability of dopaminergic neurons to MPTP.

1 reference

15 October 2024

https://opencitations.net/index/api/v1/references/10.14573/ALTEX.2013.4.427

Non-nuclear Wld(S) determines its neuroprotective efficacy for axons and synapses in vivo.

1 reference

15 October 2024

https://opencitations.net/index/api/v1/references/10.14573/ALTEX.2013.4.427

Progressive degeneration of human mesencephalic neuron-derived cells triggered by dopamine-dependent oxidative stress is dependent on the mixed-lineage kinase pathway.

1 reference

15 October 2024

https://opencitations.net/index/api/v1/references/10.14573/ALTEX.2013.4.427

alpha-Synuclein locus triplication causes Parkinson's disease

1 reference

15 October 2024

https://opencitations.net/index/api/v1/references/10.14573/ALTEX.2013.4.427

Uncoupling of ATP-depletion and cell death in human dopaminergic neurons

1 reference

15 October 2024

https://opencitations.net/index/api/v1/references/10.14573/ALTEX.2013.4.427

Wild-type alpha-synuclein interacts with pro-apoptotic proteins PKCdelta and BAD to protect dopaminergic neuronal cells against MPP+-induced apoptotic cell death

1 reference

15 October 2024

https://opencitations.net/index/api/v1/references/10.14573/ALTEX.2013.4.427

Novel technologies and an overall strategy to allow hazard assessment and risk prediction of chemicals, cosmetics, and drugs with animal-free methods.

2 references

15 October 2024

https://opencitations.net/index/api/v1/references/10.14573/ALTEX.2013.4.427

15 October 2024

https://opencitations.net/index/api/v1/citations/10.14573/ALTEX.2012.4.373

Increased dopaminergic neuron sensitivity to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in transgenic mice expressing mutant A53T alpha-synuclein

1 reference

15 October 2024

https://opencitations.net/index/api/v1/references/10.14573/ALTEX.2013.4.427

AiO, combining DNA/protein programs and oligo-management

1 reference

15 October 2024

https://opencitations.net/index/api/v1/references/10.14573/ALTEX.2013.4.427

α-Synuclein in Parkinson's disease

1 reference

15 October 2024

https://opencitations.net/index/api/v1/references/10.14573/ALTEX.2013.4.427

Alpha-synuclein knockdown attenuates MPP+ induced mitochondrial dysfunction of SH-SY5Y cells

1 reference

15 October 2024

https://opencitations.net/index/api/v1/references/10.14573/ALTEX.2013.4.427

VCP binding influences intracellular distribution of the slow Wallerian degeneration protein, Wld(S).

1 reference

15 October 2024

https://opencitations.net/index/api/v1/references/10.14573/ALTEX.2013.4.427

Role of alpha-synuclein in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in mice

1 reference

15 October 2024

https://opencitations.net/index/api/v1/references/10.14573/ALTEX.2013.4.427

Rapid, complete and large-scale generation of post-mitotic neurons from the human LUHMES cell line.

1 reference

15 October 2024

https://opencitations.net/index/api/v1/references/10.14573/ALTEX.2013.4.427

Role of alpha-synuclein protein levels in mitochondrial morphology and cell survival in cell lines

1 reference

15 October 2024

https://opencitations.net/index/api/v1/references/10.14573/ALTEX.2013.4.427

NAD(+) and axon degeneration revisited: Nmnat1 cannot substitute for Wld(S) to delay Wallerian degeneration

1 reference

15 October 2024

https://opencitations.net/index/api/v1/references/10.14573/ALTEX.2013.4.427

Absence of Wallerian Degeneration does not Hinder Regeneration in Peripheral Nerve

1 reference

15 October 2024

https://opencitations.net/index/api/v1/references/10.14573/ALTEX.2013.4.427

Site-specific interaction between α-synuclein and membranes probed by NMR-observed methionine oxidation rates

1 reference

15 October 2024

https://opencitations.net/index/api/v1/references/10.14573/ALTEX.2013.4.427

Mitochondrial fragmentation in neurodegeneration

1 reference

15 October 2024

https://opencitations.net/index/api/v1/references/10.14573/ALTEX.2013.4.427

Identifiers

DOI

10.14573/ALTEX.2013.4.427

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24173167%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24173167%20AND%20SRC:MED&resulttype=core&format=json