The intricate dance of post-translational modifications in the rhythm of life (Q39030572)

8 September 2017

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title

The intricate dance of post-translational modifications in the rhythm of life (English)

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8 September 2017

Arisa Hirano

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8 September 2017

Ying-Hui Fu

series ordinal

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8 September 2017

Louis J Ptáček

series ordinal

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8 September 2017

publication date

1 December 2016

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Nature Structural & Molecular Biology

8 September 2017

published in

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8 September 2017

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8 September 2017

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8 September 2017

page(s)

1053-1060

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Molecular bases for circadian clocks

8 September 2017

cites work

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Circadian integration of metabolism and energetics

21 January 2018

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Post-translational modifications regulate the ticking of the circadian clock.

21 January 2018

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Kinases and phosphatases in the mammalian circadian clock

21 January 2018

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A central role for ubiquitination within a circadian clock protein modification code

21 January 2018

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Post-translational modifications in circadian rhythms

21 January 2018

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An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome

21 January 2018

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Modeling of a human circadian mutation yields insights into clock regulation by PER2

21 January 2018

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The next level of complexity: crosstalk of posttranslational modifications.

21 January 2018

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Glucose sensor O-GlcNAcylation coordinates with phosphorylation to regulate circadian clock

21 January 2018

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Posttranslational mechanisms regulate the mammalian circadian clock

21 January 2018

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Human casein kinase Idelta phosphorylation of human circadian clock proteins period 1 and 2.

21 January 2018

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Phosphorylation and destabilization of human period I clock protein by human casein kinase I epsilon

21 January 2018

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Control of mammalian circadian rhythm by CKIepsilon-regulated proteasome-mediated PER2 degradation.

21 January 2018

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Control of intracellular dynamics of mammalian period proteins by casein kinase I epsilon (CKIepsilon) and CKIdelta in cultured cells

21 January 2018

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Phosphorylation of clock protein PER1 regulates its circadian degradation in normal human fibroblasts

21 January 2018

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CKIepsilon/delta-dependent phosphorylation is a temperature-insensitive, period-determining process in the mammalian circadian clock

21 January 2018

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Identification of diverse modulators of central and peripheral circadian clocks by high-throughput chemical screening

21 January 2018

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Involvement of the protein kinase CK2 in the regulation of mammalian circadian rhythms.

21 January 2018

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High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIα as a clock regulatory kinase

21 January 2018

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The Drosophila clock gene double-time encodes a protein closely related to human casein kinase Iepsilon

21 January 2018

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double-time is a novel Drosophila clock gene that regulates PERIOD protein accumulation

21 January 2018

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Positional syntenic cloning and functional characterization of the mammalian circadian mutation tau.

21 January 2018

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An opposite role for tau in circadian rhythms revealed by mathematical modeling

21 January 2018

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Setting clock speed in mammals: the CK1 epsilon tau mutation in mice accelerates circadian pacemakers by selectively destabilizing PERIOD proteins

21 January 2018

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Casein kinase 1 delta regulates the pace of the mammalian circadian clock

21 January 2018

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SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein

21 January 2018

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Beta-TrCP1-mediated degradation of PERIOD2 is essential for circadian dynamics

21 January 2018

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The role of {beta}-TrCP1 and {beta}-TrCP2 in circadian rhythm generation by mediating degradation of clock protein PER2

21 January 2018

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Early doors (Edo) mutant mouse reveals the importance of period 2 (PER2) PAS domain structure for circadian pacemaking.

21 January 2018

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Functional consequences of a CKIdelta mutation causing familial advanced sleep phase syndrome

21 January 2018

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A PERIOD3 variant causes a circadian phenotype and is associated with a seasonal mood trait

21 January 2018

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A Cryptochrome 2 mutation yields advanced sleep phase in humans

21 January 2018

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Familial advanced sleep-phase syndrome: A short-period circadian rhythm variant in humans

21 January 2018

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Casein kinase iδ mutations in familial migraine and advanced sleep phase.

21 January 2018

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PER1 phosphorylation specifies feeding rhythm in mice

21 January 2018

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Differential effects of PER2 phosphorylation: molecular basis for the human familial advanced sleep phase syndrome (FASPS)

21 January 2018

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Casein Kinase 1-dependent Phosphorylation of Familial Advanced Sleep Phase Syndrome-associated Residues Controls PERIOD 2 Stability

21 January 2018

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A Period2 Phosphoswitch Regulates and Temperature Compensates Circadian Period

21 January 2018

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Nuclear entry of the circadian regulator mPER1 is controlled by mammalian casein kinase I epsilon

21 January 2018

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Nuclear export of mammalian PERIOD proteins

21 January 2018

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Cloning and characterization of rat casein kinase 1epsilon

21 January 2018

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Identification of mPer1 phosphorylation sites responsible for the nuclear entry

21 January 2018

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Light entrainment of the mammalian circadian clock by a PRKCA-dependent posttranslational mechanism

21 January 2018

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GRK2 Fine-Tunes Circadian Clock Speed and Entrainment via Transcriptional and Post-translational Control of PERIOD Proteins

21 January 2018

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Importin alpha/beta mediates nuclear transport of a mammalian circadian clock component, mCRY2, together with mPER2, through a bipartite nuclear localization signal

21 January 2018

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Functional evolution of the photolyase/cryptochrome protein family: importance of the C terminus of mammalian CRY1 for circadian core oscillator performance.

21 January 2018

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Nuclear entry mechanism of rat PER2 (rPER2): role of rPER2 in nuclear localization of CRY protein

21 January 2018

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The period of the circadian oscillator is primarily determined by the balance between casein kinase 1 and protein phosphatase 1

21 January 2018

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Protein phosphatase 1 regulates the stability of the circadian protein PER2.

21 January 2018

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Protein phosphatase 1 (PP1) is a post-translational regulator of the mammalian circadian clock

21 January 2018

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Cryptochromes and circadian photoreception in animals

21 January 2018

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The de-ubiquitinylating enzyme, USP2, is associated with the circadian clockwork and regulates its sensitivity to light

21 January 2018

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USP2a protein deubiquitinates and stabilizes the circadian protein CRY1 in response to inflammatory signals

21 January 2018

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Regulation of behavioral circadian rhythms and clock protein PER1 by the deubiquitinating enzyme USP2.

21 January 2018

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SIRT1 regulates circadian clock gene expression through PER2 deacetylation

21 January 2018

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The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control

21 January 2018

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mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop

21 January 2018

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The after-hours mutant reveals a role for Fbxl3 in determining mammalian circadian period

21 January 2018

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Circadian mutant Overtime reveals F-box protein FBXL3 regulation of cryptochrome and period gene expression

21 January 2018

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SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins

21 January 2018

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Competing E3 ubiquitin ligases govern circadian periodicity by degradation of CRY in nucleus and cytoplasm

21 January 2018

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FBXL21 regulates oscillation of the circadian clock through ubiquitination and stabilization of cryptochromes

21 January 2018

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Implication of the F-Box Protein FBXL21 in circadian pacemaker function in mammals

21 January 2018

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CUL4-DDB1-CDT2 E3 Ligase Regulates the Molecular Clock Activity by Promoting Ubiquitination-Dependent Degradation of the Mammalian CRY1

21 January 2018

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Circadian Clock Gene CRY2 Degradation Is Involved in Chemoresistance of Colorectal Cancer.

21 January 2018

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AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation

21 January 2018

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DYRK1A and glycogen synthase kinase 3beta, a dual-kinase mechanism directing proteasomal degradation of CRY2 for circadian timekeeping

21 January 2018

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Ser-557-phosphorylated mCRY2 is degraded upon synergistic phosphorylation by glycogen synthase kinase-3 beta.

21 January 2018

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In vivo role of phosphorylation of cryptochrome 2 in the mouse circadian clock

21 January 2018

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Phosphorylation of the cryptochrome 1 C-terminal tail regulates circadian period length

21 January 2018

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USP7 and TDP-43: Pleiotropic Regulation of Cryptochrome Protein Stability Paces the Oscillation of the Mammalian Circadian Clock

21 January 2018

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SCFFBXL3 ubiquitin ligase targets cryptochromes at their cofactor pocket

21 January 2018

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Identification of small molecule activators of cryptochrome

21 January 2018

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Nucleocytoplasmic shuttling and mCRY-dependent inhibition of ubiquitylation of the mPER2 clock protein

21 January 2018

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Structures of Drosophila cryptochrome and mouse cryptochrome1 provide insight into circadian function

21 January 2018

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Interaction of circadian clock proteins CRY1 and PER2 is modulated by zinc binding and disulfide bond formation

21 January 2018

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Roles of CLOCK phosphorylation in suppression of E-box-dependent transcription

21 January 2018

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Circadian Dbp transcription relies on highly dynamic BMAL1-CLOCK interaction with E boxes and requires the proteasome

21 January 2018

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Cyclic, proteasome-mediated turnover of unliganded and liganded ERalpha on responsive promoters is an integral feature of estrogen signaling

21 January 2018

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Positional cloning of the mouse circadian clock gene

21 January 2018

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Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior

21 January 2018

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Role of the CLOCK protein in the mammalian circadian mechanism

21 January 2018

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A serine cluster mediates BMAL1-dependent CLOCK phosphorylation and degradation

21 January 2018

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Regulation of BMAL1 protein stability and circadian function by GSK3beta-mediated phosphorylation.

21 January 2018

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Cyclin-dependent kinase 5 (Cdk5) regulates the function of CLOCK protein by direct phosphorylation

21 January 2018

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PKCγ participates in food entrainment by regulating BMAL1

21 January 2018

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Dual modification of BMAL1 by SUMO2/3 and ubiquitin promotes circadian activation of the CLOCK/BMAL1 complex

21 January 2018

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Circadian clock control by SUMOylation of BMAL1.

21 January 2018

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CLOCK is a substrate of SUMO and sumoylation of CLOCK upregulates the transcriptional activity of estrogen receptor-α.

21 January 2018

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O-GlcNAc signaling entrains the circadian clock by inhibiting BMAL1/CLOCK ubiquitination

21 January 2018

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The E3 ubiquitin ligase UBE3A is an integral component of the molecular circadian clock through regulating the BMAL1 transcription factor

21 January 2018

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Circadian regulator CLOCK is a histone acetyltransferase

21 January 2018

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CLOCK-mediated acetylation of BMAL1 controls circadian function

21 January 2018

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CRY Drives Cyclic CK2-Mediated BMAL1 Phosphorylation to Control the Mammalian Circadian Clock

21 January 2018

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CK2alpha phosphorylates BMAL1 to regulate the mammalian clock

21 January 2018

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Feedback regulation of transcriptional termination by the mammalian circadian clock PERIOD complex

21 January 2018

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The mammalian circadian clock protein period counteracts cryptochrome in phosphorylation dynamics of circadian locomotor output cycles kaput (CLOCK).

21 January 2018

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Cryptochromes impair phosphorylation of transcriptional activators in the clock: a general mechanism for circadian repression

21 January 2018

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Posttranslational regulation of the mammalian circadian clock by cryptochrome and protein phosphatase 5.

21 January 2018

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The circadian regulatory proteins BMAL1 and cryptochromes are substrates of casein kinase Iepsilon

21 January 2018

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Transcriptional architecture and chromatin landscape of the core circadian clock in mammals

21 January 2018

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The histone methyltransferase MLL1 permits the oscillation of circadian gene expression

21 January 2018

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Temporal orchestration of repressive chromatin modifiers by circadian clock Period complexes

21 January 2018

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Histone lysine demethylase JARID1a activates CLOCK-BMAL1 and influences the circadian clock

21 January 2018

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BMAL1 shuttling controls transactivation and degradation of the CLOCK/BMAL1 heterodimer

21 January 2018

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BMAL1-dependent circadian oscillation of nuclear CLOCK: posttranslational events induced by dimerization of transcriptional activators of the mammalian clock system

21 January 2018

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CLOCK-controlled polyphonic regulation of circadian rhythms through canonical and noncanonical E-boxes

21 January 2018

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Rhythmic CLOCK-BMAL1 binding to multiple E-box motifs drives circadian Dbp transcription and chromatin transitions

21 January 2018

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Genome-wide and phase-specific DNA-binding rhythms of BMAL1 control circadian output functions in mouse liver

21 January 2018

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Crystal Structure of the Heterodimeric CLOCK:BMAL1 Transcriptional Activator Complex

21 January 2018

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Identification of RACK1 and protein kinase Calpha as integral components of the mammalian circadian clock.

21 January 2018

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Circadian Amplitude Regulation via FBXW7-Targeted REV-ERBα Degradation

21 January 2018

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Nuclear receptor Rev-erbalpha is a critical lithium-sensitive component of the circadian clock

21 January 2018

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E3 ligases Arf-bp1 and Pam mediate lithium-stimulated degradation of the circadian heme receptor Rev-erb alpha

21 January 2018

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Dual roles of FBXL3 in the mammalian circadian feedback loops are important for period determination and robustness of the clock

21 January 2018

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DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization

21 January 2018

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Dimerization and nuclear entry of mPER proteins in mammalian cells

31 March 2020

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PubMed

https://pubmed.ncbi.nlm.nih.gov/27922612

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Post-translational modifications and their biological functions: proteomic analysis and systematic approaches

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27922612

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NSMB.3326

1 reference

8 September 2017

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