Mutant IDH1 inhibits PI3K/Akt signaling in human glioma. (Q39000847)

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16 March 2020

title

Mutant IDH1 inhibits PI3K/Akt signaling in human glioma (English)

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16 March 2020

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16 March 2020

Sebastian F Schoppmann

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16 March 2020

Peter Birner

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16 March 2020

Christo Christov

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16 March 2020

Stiliana Mihaylova

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16 March 2020

Kalina Toumangelova-Uzeir

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16 March 2020

Sevdalin Natchev

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16 March 2020

Andrey Tchorbanov

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16 March 2020

Berthold Streubel

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16 March 2020

Jochen Tuettenberg

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16 March 2020

Marin Guentchev

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16 March 2020

language of work or name

English

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publication date

25 April 2014

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16 March 2020

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16 March 2020

volume

120

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16 March 2020

issue

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16 March 2020

page(s)

2440-2447

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IDH1 and IDH2 mutations in gliomas

16 March 2020

cites work

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IDH1 R132H decreases proliferation of glioma cell lines in vitro and in vivo

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IDH mutation impairs histone demethylation and results in a block to cell differentiation

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Targeting PI3K signalling in cancer: opportunities, challenges and limitations

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PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells

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Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma

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Expression of podoplanin in human astrocytic brain tumors is controlled by the PI3K-AKT-AP-1 signaling pathway and promoter methylation

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Increased expression of podoplanin in malignant astrocytic tumors as a novel molecular marker of malignant progression

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Genomic and expression profiling of glioblastoma stem cell-like spheroid cultures identifies novel tumor-relevant genes associated with survival

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Rembrandt: helping personalized medicine become a reality through integrative translational research

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Enzymatic assay for quantitative analysis of (D)-2-hydroxyglutarate

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21 January 2018

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Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas.

21 January 2018

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An integrated genomic analysis of human glioblastoma multiforme

21 January 2018

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The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo

21 January 2018

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Recurring mutations found by sequencing an acute myeloid leukemia genome

21 January 2018

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IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours

21 January 2018

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Frequent mutation of isocitrate dehydrogenase (IDH)1 and IDH2 in cholangiocarcinoma identified through broad-based tumor genotyping

21 January 2018

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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

21 January 2018

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Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha

21 January 2018

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An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells.

21 January 2018

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IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype

21 January 2018

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