Critical differences in toxicity mechanisms in induced pluripotent stem cell-derived hepatocytes, hepatic cell lines and primary hepatocytes (Q38986528)

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English	Critical differences in toxicity mechanisms in induced pluripotent stem cell-derived hepatocytes, hepatic cell lines and primary hepatocytes	scientific article

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

8 September 2017

Critical differences in toxicity mechanisms in induced pluripotent stem cell-derived hepatocytes, hepatic cell lines and primary hepatocytes (English)

1 reference

Europe PubMed Central

PubMed publication ID

8 September 2017

author name string

Anna-Karin M Sjogren

1

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Europe PubMed Central

PubMed publication ID

8 September 2017

Maria Liljevald

2

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Europe PubMed Central

PubMed publication ID

8 September 2017

Björn Glinghammar

3

1 reference

Europe PubMed Central

PubMed publication ID

8 September 2017

Johanna Sagemark

4

1 reference

Europe PubMed Central

PubMed publication ID

8 September 2017

Xue-Qing Li

5

1 reference

Europe PubMed Central

PubMed publication ID

8 September 2017

Anna Jonebring

6

1 reference

Europe PubMed Central

PubMed publication ID

8 September 2017

Ian Cotgreave

7

1 reference

Europe PubMed Central

PubMed publication ID

8 September 2017

Gabriella Brolén

8

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Europe PubMed Central

PubMed publication ID

8 September 2017

Tommy B Andersson

9

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Europe PubMed Central

PubMed publication ID

8 September 2017

publication date

10 June 2014

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Europe PubMed Central

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8 September 2017

Archives of Toxicology

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Europe PubMed Central

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8 September 2017

88

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Europe PubMed Central

PubMed publication ID

8 September 2017

7

1 reference

Europe PubMed Central

PubMed publication ID

8 September 2017

1427-1437

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Europe PubMed Central

PubMed publication ID

8 September 2017

Optimization of the HepaRG cell model for drug metabolism and toxicity studies

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1265-Z

21 January 2018

Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1265-Z

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N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen

1 reference

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21 January 2018

Acute liver necrosis following overdose of paracetamol

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1265-Z

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Mechanism of staurosporine-induced apoptosis in murine hepatocytes

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1265-Z

21 January 2018

Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1265-Z

21 January 2018

Infection of a human hepatoma cell line by hepatitis B virus

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1265-Z

21 January 2018

Similarities and Differences in the Expression of Drug-Metabolizing Enzymes between Human Hepatic Cell Lines and Primary Human Hepatocytes

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1265-Z

21 January 2018

Efficient differentiation of hepatocytes from human embryonic stem cells exhibiting markers recapitulating liver development in vivo.

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1265-Z

21 January 2018

Mechanisms of acetaminophen-induced liver necrosis

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1265-Z

21 January 2018

Evaluation of HepaRG cells as an in vitro model for human drug metabolism studies

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1265-Z

21 January 2018

HepaRG cells as an in vitro model for evaluation of cytochrome P450 induction in humans

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1265-Z

21 January 2018

Stem cell-derived hepatocytes as a predictive model for drug-induced liver injury: are we there yet?

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1265-Z

21 January 2018

Can the pharmaceutical industry reduce attrition rates?

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1265-Z

21 January 2018

Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1265-Z

21 January 2018

Comparative analysis of phase I and II enzyme activities in 5 hepatic cell lines identifies Huh-7 and HCC-T cells with the highest potential to study drug metabolism

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1265-Z

21 January 2018

Apoptosis and necrosis in the liver: a tale of two deaths?

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1265-Z

21 January 2018

HepaRG Cells: A Human Model to Study Mechanisms of Acetaminophen Hepatotoxicity Δσ

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1265-Z

21 January 2018

The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1265-Z

21 January 2018

Preapoptotic cell stress response of primary hepatocytes

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1265-Z

21 January 2018

A high content screening assay to predict human drug-induced liver injury during drug discovery

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1265-Z

21 January 2018

Cell culture model for acetaminophen-induced hepatocyte death in vivo

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1265-Z

21 January 2018

Character and temporal evolution of apoptosis in acetaminophen-induced acute liver failure*.

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1265-Z

21 January 2018

Absolute quantification and differential expression of drug transporters, cytochrome P450 enzymes, and UDP-glucuronosyltransferases in cultured primary human hepatocytes

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1265-Z

21 January 2018

An anti-apoptotic protein human survivin is a direct inhibitor of caspase-3 and -7

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1265-Z

21 January 2018

Hepatic differentiation and maturation of human embryonic stem cells cultured in a perfused three-dimensional bioreactor

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1265-Z

21 January 2018

Generation of functional human hepatic endoderm from human induced pluripotent stem cells

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1265-Z

21 January 2018

3D spheroid culture of hESC/hiPSC-derived hepatocyte-like cells for drug toxicity testing

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1265-Z

21 January 2018

Drug metabolizing enzyme and transporter protein profiles of hepatocytes derived from human embryonic and induced pluripotent stem cells

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1265-Z

21 January 2018

Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA.

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1265-Z

21 January 2018

Present state and future perspectives of using pluripotent stem cells in toxicology research

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1265-Z

21 January 2018

Human embryonic stem cell derived hepatocyte-like cells as a tool for in vitro hazard assessment of chemical carcinogenicity

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1265-Z

21 January 2018

Identifiers

10.1007/S00204-014-1265-Z

1 reference

Europe PubMed Central

PubMed publication ID

8 September 2017

Dimensions Publication ID

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PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

8 September 2017

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