Targeting microsomal triglyceride transfer protein and lipoprotein assembly to treat homozygous familial hypercholesterolemia (Q38969073)

8 September 2017

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title

Targeting microsomal triglyceride transfer protein and lipoprotein assembly to treat homozygous familial hypercholesterolemia (English)

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homozygous familial hypercholesterolemia

8 September 2017

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Meghan T Walsh

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8 September 2017

M Mahmood Hussain

series ordinal

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8 September 2017

publication date

1 October 2016

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Critical Reviews in Clinical Laboratory Sciences

8 September 2017

published in

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8 September 2017

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8 September 2017

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8 September 2017

page(s)

26-48

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Familial hypercholesterolemia and coronary heart disease: a HuGE association review

8 September 2017

cites work

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Genetic causes of monogenic heterozygous familial hypercholesterolemia: a HuGE prevalence review

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Demonstration of a physical interaction between microsomal triglyceride transfer protein and apolipoprotein B during the assembly of ApoB-containing lipoproteins

21 January 2018

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Interactions between microsomal triglyceride transfer protein and apolipoprotein B within the endoplasmic reticulum in a heterologous expression system.

21 January 2018

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Lysine and arginine residues in the N-terminal 18% of apolipoprotein B are critical for its binding to microsomal triglyceride transfer protein

21 January 2018

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Contemporary aspects of the biology and therapeutic regulation of the microsomal triglyceride transfer protein

21 January 2018

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Lomitapide and mipomersen: two first-in-class drugs for reducing low-density lipoprotein cholesterol in patients with homozygous familial hypercholesterolemia

21 January 2018

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Progress towards understanding the role of microsomal triglyceride transfer protein in apolipoprotein-B lipoprotein assembly

21 January 2018

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The many intersecting pathways underlying apolipoprotein B secretion and degradation

21 January 2018

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The structure of human high density lipoprotein and the levels of apolipoprotein A-I in plasma as determined by radioimmunoassay

21 January 2018

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Synthesis and transport of lipoprotein particles by intestinal absorptive cells in man

21 January 2018

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Synthesis of two forms of apolipoprotein B by cultured rat hepatocytes

21 January 2018

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Molecular cloning of an apolipoprotein B messenger RNA editing protein

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Apolipoprotein B-48 is the product of a messenger RNA with an organ-specific in-frame stop codon

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

A novel form of tissue-specific RNA processing produces apolipoprotein-B48 in intestine

21 January 2018

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The structure of vitellogenin provides a molecular model for the assembly and secretion of atherogenic lipoproteins

21 January 2018

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Apolipoprotein B-containing lipoprotein particle assembly: lipid capacity of the nascent lipoprotein particle

21 January 2018

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Assembly of lipoprotein particles containing apolipoprotein-B: structural model for the nascent lipoprotein particle

21 January 2018

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Surface tensiometry of apolipoprotein B domains at lipid interfaces suggests a new model for the initial steps in triglyceride-rich lipoprotein assembly

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Interfacial properties of apolipoprotein B292-593 (B6.4-13) and B611-782 (B13-17). Insights into the structure of the lipovitellin homology region in apolipoprotein B.

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Identification of the lipoprotein initiating domain of apolipoprotein B.

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

The amino terminus of apolipoprotein B is necessary but not sufficient for microsomal triglyceride transfer protein responsiveness

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Identification of the proteoglycan binding site in apolipoprotein B48.

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Molecular mechanism for changes in proteoglycan binding on compositional changes of the core and the surface of low-density lipoprotein-containing human apolipoprotein B100.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Reconstituting initial events during the assembly of apolipoprotein B-containing lipoproteins in a cell-free system.

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Ubiquitination regulates the assembly of VLDL in HepG2 cells and is the committing step of the apoB-100 ERAD pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Phospholipid transfer activity of microsomal triglyceride transfer protein produces apolipoprotein B and reduces hepatosteatosis while maintaining low plasma lipids in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Cideb facilitates the lipidation of chylomicrons in the small intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Opposing roles of cell death-inducing DFF45-like effector B and perilipin 2 in controlling hepatic VLDL lipidation

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Multiple functions of microsomal triglyceride transfer protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Phospholipid transfer protein plays a major role in the initiation of apolipoprotein B-containing lipoprotein assembly in mouse primary hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Microsomal Triglyceride Transfer Protein Transfers and Determines Plasma Concentrations of Ceramide and Sphingomyelin but Not Glycosylceramide

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

A simple, rapid, and sensitive fluorescence assay for microsomal triglyceride transfer protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

A Drosophila microsomal triglyceride transfer protein homolog promotes the assembly and secretion of human apolipoprotein B. Implications for human and insect transport and metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Acquisition of triacylglycerol transfer activity by microsomal triglyceride transfer protein during evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Phospholipid transfer activity of microsomal triacylglycerol transfer protein is sufficient for the assembly and secretion of apolipoprotein B lipoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Cideb, an ER- and lipid droplet-associated protein, mediates VLDL lipidation and maturation by interacting with apolipoprotein B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

The impact of phospholipid transfer protein (PLTP) on lipoprotein metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Liver-specific phospholipid transfer protein deficiency reduces high-density lipoprotein and non-high-density lipoprotein production in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

The degradation of apolipoprotein B100: multiple opportunities to regulate VLDL triglyceride production by different proteolytic pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Liver phospholipid transfer protein (PLTP) expression with a PLTP-null background promotes very low-density lipoprotein production in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Very-low-density lipoprotein assembly and secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Intracellular assembly of VLDL: two major steps in separate cell compartments

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Intestinal lipoprotein assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

A proposed model for the assembly of chylomicrons

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Lumenal lipid metabolism: implications for lipoprotein assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Membrane lipids: where they are and how they behave

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Lipid droplet formation on opposing sides of the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Proteomic and lipid characterization of apolipoprotein B-free luminal lipid droplets from mouse liver microsomes: implications for very low density lipoprotein assembly.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

The activity of microsomal triglyceride transfer protein is essential for accumulation of triglyceride within microsomes in McA-RH7777 cells. A unified model for the assembly of very low density lipoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Intrahepatic role of exchangeable apolipoproteins in lipoprotein assembly and secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Microsome-associated lumenal lipid droplets in the regulation of lipoprotein secretion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Overexpression of apolipoprotein A-IV enhances lipid secretion in IPEC-1 cells by increasing chylomicron size

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Circadian regulation of intestinal lipid absorption by apolipoprotein AIV involves forkhead transcription factors A2 and O1 and microsomal triglyceride transfer protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

ApoA-IV modulates the secretory trafficking of apoB and the size of triglyceride-rich lipoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Regulation of microsomal triglyceride transfer protein by apolipoprotein A-IV in newborn swine intestinal epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Impaired secretion of very low density lipoprotein-triglycerides by apolipoprotein E- deficient mouse hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Intestinal lipid absorption

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

CideB protein is required for the biogenesis of very low density lipoprotein (VLDL) transport vesicle

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

A regulator of secretory vesicle size, Kelch-like protein 12, facilitates the secretion of apolipoprotein B100 and very-low-density lipoproteins--brief report

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Silencing of Small Valosin-containing Protein-interacting Protein (SVIP) Reduces Very Low Density Lipoprotein (VLDL) Secretion from Rat Hepatocytes by Disrupting Its Endoplasmic Reticulum (ER)-to-Golgi Trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

The identification of the SNARE complex required for the fusion of VLDL-transport vesicle with hepatic cis-Golgi

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Intracellular trafficking and secretion of VLDL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Control of chylomicron export from the intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

A novel multiprotein complex is required to generate the prechylomicron transport vesicle from intestinal ER

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Development and physiological regulation of intestinal lipid absorption. II. Dietary lipid absorption, complex lipid synthesis, and the intracellular packaging and secretion of chylomicrons

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

The identification of a novel endoplasmic reticulum to Golgi SNARE complex used by the prechylomicron transport vesicle

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

The genes and proteins of atherogenic lipoprotein production

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Mutations in a Sar1 GTPase of COPII vesicles are associated with lipid absorption disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Anderson or chylomicron retention disease: molecular impact of five mutations in the SAR1B gene on the structure and the functionality of Sar1b protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Localization of microsomal triglyceride transfer protein in the Golgi: possible role in the assembly of chylomicrons

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Apolipoprotein B secretory regulation by degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Presecretory oxidation, aggregation, and autophagic destruction of apoprotein-B: a pathway for late-stage quality control

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Complexity in the secretory pathway: the assembly and secretion of apolipoprotein B-containing lipoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Absence of microsomal triglyceride transfer protein in individuals with abetalipoproteinemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Cloning and gene defects in microsomal triglyceride transfer protein associated with abetalipoproteinaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

A novel abetalipoproteinemia genotype. Identification of a missense mutation in the 97-kDa subunit of the microsomal triglyceride transfer protein that prevents complex formation with protein disulfide isomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

IRE1α-XBP1s induces PDI expression to increase MTP activity for hepatic VLDL assembly and lipid homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Identification of two classes of lipid molecule binding sites on the microsomal triglyceride transfer protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Novel Abetalipoproteinemia Missense Mutation Highlights the Importance of the N-Terminal β-Barrel in Microsomal Triglyceride Transfer Protein Function

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

The Enzymatic and Non-enzymatic Roles of Protein-disulfide Isomerase in Apolipoprotein B Secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

The role of protein disulphide isomerase in the microsomal triacylglycerol transfer protein does not reside in its isomerase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

The structural basis of lipid interactions in lipovitellin, a soluble lipoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Microsomal triglyceride transfer protein and its role in apoB-lipoprotein assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

The N-terminal 1000 residues of apolipoprotein B associate with microsomal triglyceride transfer protein to create a lipid transfer pocket required for lipoprotein assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

A common binding site on the microsomal triglyceride transfer protein for apolipoprotein B and protein disulfide isomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Apo B100-containing lipoproteins are secreted by the heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Molecular diversity and evolution of the large lipid transfer protein superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Human placenta secretes apolipoprotein B-100-containing lipoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

MTP regulated by an alternate promoter is essential for NKT cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Human luteinized granulosa cells secrete apoB100-containing lipoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Expression of apolipoprotein B in the kidney attenuates renal lipid accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Allele-specific regulation of MTTP expression influences the risk of ischemic heart disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Retina expresses microsomal triglyceride transfer protein: implications for age-related maculopathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Microsomal triglyceride transfer protein lipidation and control of CD1d on antigen-presenting cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Microsomal triglyceride transfer protein regulates endogenous and exogenous antigen presentation by group 1 CD1 molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

CD1d function is regulated by microsomal triglyceride transfer protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Microsomal triglyceride transfer protein expression in adipocytes: a new component in fat metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Microsomal Triglyceride Transfer Protein (MTP) Associates with Cytosolic Lipid Droplets in 3T3-L1 Adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Mice subjected to aP2-Cre mediated ablation of microsomal triglyceride transfer protein are resistant to high fat diet induced obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Knockout of the abetalipoproteinemia gene in mice: reduced lipoprotein secretion in heterozygotes and embryonic lethality in homozygotes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Analysis of the role of microsomal triglyceride transfer protein in the liver of tissue-specific knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Microsomal triglyceride transfer protein enhances cellular cholesteryl esterification by relieving product inhibition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Differential impact of hepatic deficiency and total body inhibition of MTP on cholesterol metabolism and RCT in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Hepatic Mttp deletion reverses gallstone susceptibility in L-Fabp knockout mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Blocking the secretion of hepatic very low density lipoproteins renders the liver more susceptible to toxin-induced injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Lipid absorption defects in intestine-specific microsomal triglyceride transfer protein and ATP-binding cassette transporter A1-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Compensatory increase in hepatic lipogenesis in mice with conditional intestine-specific Mttp deficiency.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Protective mucosal immunity mediated by epithelial CD1d and IL-10.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Intestine-Specific Mttp Deletion Increases the Severity of Experimental Colitis and Leads to Greater Tumor Burden in a Model of Colitis Associated Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Lipoprotein secretion and triglyceride stores in the heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

A 30-amino acid truncation of the microsomal triglyceride transfer protein large subunit disrupts its interaction with protein disulfide-isomerase and causes abetalipoproteinemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Molecular and functional analysis of two new MTTP gene mutations in an atypical case of abetalipoproteinemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Loss of both phospholipid and triglyceride transfer activities of microsomal triglyceride transfer protein in abetalipoproteinemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Novel missense MTTP gene mutations causing abetalipoproteinemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Monogenic dyslipidemias: window on determinants of plasma lipoprotein metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Hypobetalipoproteinemia with abnormal prebetalipoprotein

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Long-term management of abetalipoproteinaemia. Possible role for vitamin E

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Abetalipoproteinemia: two case reports and literature review

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Primary deficiency of microsomal triglyceride transfer protein in human abetalipoproteinemia is associated with loss of CD1 function

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Abetalipoproteinemia and homozygous hypobetalipoproteinemia: a framework for diagnosis and management

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Fat-soluble vitamin deficiency in pregnancy: a case report and review of abetalipoproteinemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Maternal abetalipoproteinemia resulting in multiple fetal anomalies

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Persistence of the intestinal defect in abetalipoproteinaemia after liver transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

The microsomal triglyceride transfer protein gene-493T variant lowers cholesterol but increases the risk of coronary heart disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

MTP inhibitor decreases plasma cholesterol levels in LDL receptor-deficient WHHL rabbits by lowering the VLDL secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Blocking microsomal triglyceride transfer protein interferes with apoB secretion without causing retention or stress in the ER.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Implitapide, a microsomal triglyceride transfer protein inhibitor, reduces progression of atherosclerosis in apolipoprotein E knockout mice fed a Western-type diet: involvement of the inhibition of postprandial triglyceride elevation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Rapid regression of atherosclerosis with MTP inhibitor treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Microsomal triglyceride transfer protein inhibition induces endoplasmic reticulum stress and increases gene transcription via Ire1α/cJun to enhance plasma ALT/AST

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Rescue of Mtp siRNA-induced hepatic steatosis by DGAT2 siRNA silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

MicroRNA-30c reduces hyperlipidemia and atherosclerosis in mice by decreasing lipid synthesis and lipoprotein secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

A Small-Molecule Inhibitor of Enterocytic Microsomal Triglyceride Transfer Protein, SLx-4090: Biochemical, Pharmacodynamic, Pharmacokinetic, and Safety Profile

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

JTT-130, a novel intestine-specific inhibitor of microsomal triglyceride transfer protein, ameliorates lipid metabolism and attenuates atherosclerosis in hyperlipidemic animal models.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Pharmacological Characterization of Diethyl-2-({3-dimethylcarbamoyl-4-[(4′-trifluoromethylbiphenyl-2-carbonyl)amino]phenyl}acetyloxymethyl)-2-phenylmalonate (JTT-130), an Intestine-Specific Inhibitor of Microsomal Triglyceride Transfer Protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

JTT-130, a microsomal triglyceride transfer protein (MTP) inhibitor lowers plasma triglycerides and LDL cholesterol concentrations without increasing hepatic triglycerides in guinea pigs

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

JTT-130, a novel intestine-specific inhibitor of microsomal triglyceride transfer protein, reduces food preference for fat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Biologic activity of dirlotapide, a novel microsomal triglyceride transfer protein inhibitor, for weight loss in obese dogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

An evaluation of dirlotapide to reduce body weight of client-owned dogs in two placebo-controlled clinical studies in Europe

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Assignment of the human gene for the low density lipoprotein receptor to chromosome 19: synteny of a receptor, a ligand, and a genetic disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Familial hypercholesterolemia: defective binding of lipoproteins to cultured fibroblasts associated with impaired regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Altered metabolism of low-density lipoprotein and very-low-density lipoprotein remnant in autosomal recessive hypercholesterolemia: results from stable isotope kinetic study in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Apolipoprotein B100 metabolism in autosomal-dominant hypercholesterolemia related to mutations in PCSK9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

The role of the LDL receptor in apolipoprotein B secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Familial hypercholesterolemia: identification of a defect in the regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity associated with overproduction of cholesterol

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

A new but frequent mutation of apoB-100-apoB His3543Tyr

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Mutations in PCSK9 cause autosomal dominant hypercholesterolemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Familial hypercholesterolemias: prevalence, genetics, diagnosis and screening recommendations from the National Lipid Association Expert Panel on Familial Hypercholesterolemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Mechanisms of disease: genetic causes of familial hypercholesterolemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

A novel type of familial hypercholesterolemia: double heterozygous mutations in LDL receptor and LDL receptor adaptor protein 1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Arterial endothelial function and wall thickness in familial hypercholesterolemia and familial combined hyperlipidemia and the effect of statins. A systematic review and meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Carotid intima-media thickness in children with familial hypercholesterolemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Femoral atherosclerosis in heterozygous familial hypercholesterolemia: influence of the genetic defect.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

The low density lipoprotein receptor is not required for normal catabolism of Lp(a) in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Correlating corneal arcus with atherosclerosis in familial hypercholesterolemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Intensive versus moderate lipid lowering with statins after acute coronary syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Statin therapy in a kindred with both apolipoprotein B and low density lipoprotein receptor gene defects

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Efficacy and safety of ezetimibe coadministered with atorvastatin or simvastatin in patients with homozygous familial hypercholesterolemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

PCSK9 inhibition with evolocumab (AMG 145) in heterozygous familial hypercholesterolaemia (RUTHERFORD-2): a randomised, double-blind, placebo-controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Characterization of Autosomal Dominant Hypercholesterolemia Caused by PCSK9 Gain of Function Mutations and Its Specific Treatment With Alirocumab, a PCSK9 Monoclonal Antibody.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Efficacy and safety of evolocumab in reducing lipids and cardiovascular events.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Effect of the proprotein convertase subtilisin/kexin 9 monoclonal antibody, AMG 145, in homozygous familial hypercholesterolemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Low-density lipoprotein cholesterol-lowering effects of AMG 145, a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 serine protease in patients with heterozygous familial hypercholesterolemia: the Reduction of LDL-C with PCSK9 In

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Liver transplantation to provide low-density-lipoprotein receptors and lower plasma cholesterol in a child with homozygous familial hypercholesterolemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Heart-liver transplantation in a patient with familial hypercholesterolaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Liver transplantation for the treatment of homozygous familial hypercholesterolaemia in an era of emerging lipid-lowering therapies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Translational Lessons from a Case of Combined Heart and Liver Transplantation for Familial Hypercholesterolemia 20 Years Post-operatively

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Efficacy and safety of a microsomal triglyceride transfer protein inhibitor in patients with homozygous familial hypercholesterolaemia: a single-arm, open-label, phase 3 study

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Mipomersen, an apolipoprotein B synthesis inhibitor, lowers low-density lipoprotein cholesterol in high-risk statin-intolerant patients: a randomized, double-blind, placebo-controlled trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Potent reduction of apolipoprotein B and low-density lipoprotein cholesterol by short-term administration of an antisense inhibitor of apolipoprotein B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Mipomersen, an apolipoprotein B synthesis inhibitor, for lowering of LDL cholesterol concentrations in patients with homozygous familial hypercholesterolaemia: a randomised, double-blind, placebo-controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Mipomersen, an antisense oligonucleotide to apolipoprotein B-100, reduces lipoprotein(a) in various populations with hypercholesterolemia: results of 4 phase III trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Liver histology during Mipomersen therapy for severe hypercholesterolemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Inhibition of microsomal triglyceride transfer protein in familial hypercholesterolemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Long-term clinical results of microsomal triglyceride transfer protein inhibitor use in a patient with homozygous familial hypercholesterolemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Clinical experience of lomitapide therapy in patients with homozygous familial hypercholesterolaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Treating homozygous familial hypercholesterolemia in a real-world setting: Experiences with lomitapide

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

CP-346086: an MTP inhibitor that lowers plasma cholesterol and triglycerides in experimental animals and in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Microsomal transfer protein inhibition in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

The lipid-lowering effects of lomitapide are unaffected by adjunctive apheresis in patients with homozygous familial hypercholesterolaemia - a post-hoc analysis of a Phase 3, single-arm, open-label trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Inhibition of microsomal triglyceride transfer protein alone or with ezetimibe in patients with moderate hypercholesterolemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Severe hypertriglyceridemia with pancreatitis: thirteen years' treatment with lomitapide

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Efficacy and safety of mipomersen in treatment of dyslipidemia: a meta-analysis of randomized controlled trials.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

PCSK9 inhibitors and neurocognitive adverse events: exploring the FDA directive and a proposal for N-of-1 trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Lack of pharmacokinetic interaction of mipomersen sodium (ISIS 301012), a 2'-O-methoxyethyl modified antisense oligonucleotide targeting apolipoprotein B-100 messenger RNA, with simvastatin and ezetimibe.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Novel mutations in microsomal triglyceride transfer protein including maternal uniparental disomy in two patients with abetalipoproteinemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

Implementing American Heart Association Pediatric and Adult Nutrition Guidelines

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408363.2016.1221883

10.1080/10408363.2016.1221883

21 January 2018

Identifiers

DOI

1 reference

release_oquze6fxlzfvhoe7se5pcoffdi

8 September 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/oquze6fxlzfvhoe7se5pcoffdi

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference