PKA reduces the rat and human KCa3.1 current, CaM binding, and Ca2+ signaling, which requires Ser332/334 in the CaM-binding C terminus (Q38951452)

25274816

7 September 2017

title

PKA reduces the rat and human KCa3.1 current, CaM binding, and Ca2+ signaling, which requires Ser332/334 in the CaM-binding C terminus (English)

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7 September 2017

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ChEBI release 2020-05-28

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6608312&resulttype=core&format=json

15 May 2020

Raymond Wong

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6608312&resulttype=core&format=json

15 May 2020

language of work or name

English

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publication date

1 October 2014

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25274816

7 September 2017

published in

Journal of Neuroscience

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15 May 2020

volume

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6608312&resulttype=core&format=json

15 May 2020

issue

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6608312&resulttype=core&format=json

15 May 2020

page(s)

13371-13383

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6608312&resulttype=core&format=json

Calmodulin mediates calcium-dependent activation of the intermediate conductance KCa channel, IKCa1

15 May 2020

cites work

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Mechanism-based design of a protein kinase inhibitor

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K+ channels and the microglial respiratory burst

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Structure of the gating domain of a Ca2+-activated K+ channel complexed with Ca2+/calmodulin

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Neuronal cyclic AMP controls the developmental loss in ability of axons to regenerate.

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Calmodulin regulates assembly and trafficking of SK4/IK1 Ca2+-activated K+ channels

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Characterisation of the rat SK4/IK1 K(+) channel.

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Modulation of the ERG K+ current by the tyrosine phosphatase, SHP-1.

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PKA-mediated inhibition of a novel K+ channel underlies the slow after-hyperpolarization in enteric AH neurons

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ATP-dependent regulation of SK4/IK1-like currents in rat submandibular acinar cells: possible role of cAMP-dependent protein kinase

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A role for cAMP in regeneration of the adult mammalian CNS.

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cAMP and Schwann cells promote axonal growth and functional recovery after spinal cord injury

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The phosphodiesterase inhibitor rolipram delivered after a spinal cord lesion promotes axonal regeneration and functional recovery

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Protein kinase A inhibits intermediate conductance Ca2+-activated K+ channels expressed in Xenopus oocytes

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Protein kinase A mediates microglial activation induced by plasminogen and gangliosides

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Tenascin-R plays a role in neuroprotection via its distinct domains that coordinate to modulate the microglia function

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Gene expression profiles in HEK-293 cells with low or high store-operated calcium entry: can regulatory as well as regulated genes be identified?

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Adenosine A2A receptor stimulation potentiates nitric oxide release by activated microglia

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cAMP cascade (PKA, Epac, adenylyl cyclase, Gi, and phosphodiesterases) regulates myelin phagocytosis mediated by complement receptor-3 and scavenger receptor-AI/II in microglia and macrophages

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The selective A2A receptor antagonist SCH 58261 protects from neurological deficit, brain damage and activation of p38 MAPK in rat focal cerebral ischemia.

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Adenosine receptors as therapeutic targets

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Cross-talk between G(s)- and G(q)-coupled pathways in regulation of interleukin-4 by A(2B) adenosine receptors in human mast cells.

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Cells move when ions and water flow

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The Ca2+-activated K+ channel KCNN4/KCa3.1 contributes to microglia activation and nitric oxide-dependent neurodegeneration

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Emerging adenosine receptor agonists

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Small-conductance Cl- channels contribute to volume regulation and phagocytosis in microglia.

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Expression analysis of G Protein-Coupled Receptors in mouse macrophages

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K+ channel modulators for the treatment of neurological disorders and autoimmune diseases

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Protein histidine phosphatase 1 negatively regulates CD4 T cells by inhibiting the K+ channel KCa3.1

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The Ca2+ release-activated Ca2+ current (I(CRAC)) mediates store-operated Ca2+ entry in rat microglia

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Adenosine A(2A) receptor mediates microglial process retraction

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Vascular KCa-channels as therapeutic targets in hypertension and restenosis disease.

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The Ca2+ activated SK3 channel is expressed in microglia in the rat striatum and contributes to microglia-mediated neurotoxicity in vitro

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Endothelium-derived hyperpolarising factors and associated pathways: a synopsis

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Dominance of E. coli phagocytosis over LPS in the inflammatory response of microglia

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Expression of G protein-coupled receptors and related proteins in HEK293, AtT20, BV2, and N18 cell lines as revealed by microarray analysis

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Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3',5'-cyclic phosphorothioates.

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Distinct roles for I(T) and I(H) in controlling the frequency and timing of rebound spike responses

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Inhibition of the Ca²⁺-dependent K⁺ channel, KCNN4/KCa3.1, improves tissue protection and locomotor recovery after spinal cord injury

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Therapeutic potential of KCa3.1 blockers: recent advances and promising trends

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The Lymphocyte Potassium Channels Kv1.3 and KCa3.1 as Targets for Immunosuppression

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CRACM/Orai ion channel expression and function in human lung mast cells

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Modafinil inhibits K(Ca)3.1 currents and muscle contraction via a cAMP-dependent mechanism

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Microglial SK3 and SK4 currents and activation state are modulated by the neuroprotective drug, riluzole

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Regulation of NADPH oxidase gene expression with PKA and cytokine IL-4 in neurons and microglia

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Microglial KCa3.1 Channels as a Potential Therapeutic Target for Alzheimer's Disease

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Trafficking of intermediate (KCa3.1) and small (KCa2.x) conductance, Ca(2+)-activated K(+) channels: a novel target for medicinal chemistry efforts?

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Interaction between p68 RNA helicase and Ca2+-calmodulin promotes cell migration and metastasis

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12 December 2020

Activation of microglial cells triggers a release of brain-derived neurotrophic factor (BDNF) inducing their proliferation in an adenosine A2A receptor-dependent manner: A2A receptor blockade prevents BDNF release and proliferation of microglia

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SK4 Ca2+ activated K+ channel is a critical player in cardiac pacemaker derived from human embryonic stem cells.

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12 December 2020

The intermediate conductance calcium-activated potassium channel KCa3.1 regulates vascular smooth muscle cell proliferation via controlling calcium-dependent signaling

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Selective activation of KCa3.1 and CRAC channels by P2Y2 receptors promotes Ca(2+) signaling, store refilling and migration of rat microglial cells

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12 December 2020

The microglial activation state regulates migration and roles of matrix-dissolving enzymes for invasion

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12 December 2020

Comparison of anti-inflammatory potential of four different dibenzocyclooctadiene lignans in microglia; action via activation of PKA and Nrf-2 signaling and inhibition of MAPK/STAT/NF-κB pathways

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12 December 2020

Selective inhibition of KCa3.1 channels mediates adenosine regulation of the motility of human T cells

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IL-4 type 1 receptor signaling up-regulates KCNN4 expression, and increases the KCa3.1 current and its contribution to migration of alternative-activated microglia

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[3H]CGS 21680, a selective A2 adenosine receptor agonist directly labels A2 receptors in rat brain

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A new generation of Ca2+ indicators with greatly improved fluorescence properties

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Interaction between D-glyceraldehyde-3-phosphate dehydrogenase and calmodulin

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Pharmacological properties of Ca2+-activated K+ currents of ramified murine brain macrophages

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Ca(2+)-dependent mechanisms of cell injury in cultured cortical neurons

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Modulation of Ca2+-activated K+ channels of human erythrocytes by endogenous cAMP-dependent protein kinase.

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12 December 2020

10.1523/JNEUROSCI.1008-14.2014

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6608312&resulttype=core&format=json

15 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6608312&resulttype=core&format=json

15 May 2020

25274816

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6608312&resulttype=core&format=json