Binding of fusion protein FLSC IgG1 to CCR5 is enhanced by CCR5 antagonist Maraviroc. (Q38934421)

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23 February 2020

title

Binding of fusion protein FLSC IgG1 to CCR5 is enhanced by CCR5 antagonist Maraviroc (English)

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23 February 2020

Olga Latinovic

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23 February 2020

Kate Schneider

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23 February 2020

Henryk Szmacinski

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23 February 2020

Joseph R Lakowicz

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23 February 2020

Alonso Heredia

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23 February 2020

Robert R Redfield

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23 February 2020

publication date

24 October 2014

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23 February 2020

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23 February 2020

volume

112

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23 February 2020

page(s)

80-90

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A critical site in the core of the CCR5 chemokine receptor required for binding and infectivity of human immunodeficiency virus type 1.

23 February 2020

cites work

1 reference

12 December 2020

Nef does not affect the efficiency of human immunodeficiency virus type 1 fusion with target cells

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12 December 2020

The entry of entry inhibitors: a fusion of science and medicine

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12 December 2020

An alteration of human immunodeficiency virus gp41 leads to reduced CCR5 dependence and CD4 independence

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12 December 2020

An immunoglobulin fusion protein based on the gp120-CD4 receptor complex potently inhibits human immunodeficiency virus type 1 in vitro

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12 December 2020

CCR5 antibodies HGS004 and HGS101 preferentially inhibit drug-bound CCR5 infection and restore drug sensitivity of Maraviroc-resistant HIV-1 in primary cells

1 reference

12 December 2020

CCR5 as a natural and modulated target for inhibition of HIV.

1 reference

12 December 2020

HIV taken by STORM: super-resolution fluorescence microscopy of a viral infection

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12 December 2020

Immunoadhesins as research tools and therapeutic agents

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12 December 2020

Synergistic inhibition of R5 HIV-1 by maraviroc and CCR5 antibody HGS004 in primary cells: implications for treatment and prevention

1 reference

12 December 2020

The discovery of the CCR5 receptor antagonist, UK-427,857, a new agent for the treatment of HIV infection and AIDS.

1 reference

12 December 2020

Rapamycin causes down-regulation of CCR5 and accumulation of anti-HIV beta-chemokines: an approach to suppress R5 strains of HIV-1.

1 reference

12 December 2020

Structure of the CCR5 Chemokine Receptor-HIV Entry Inhibitor Maraviroc Complex

1 reference

12 December 2020

Clustering and mobility of HIV-1 Env at viral assembly sites predict its propensity to induce cell-cell fusion.

1 reference

12 December 2020

Effects of CCR5 and CD4 cell surface concentrations on infections by macrophagetropic isolates of human immunodeficiency virus type 1.

1 reference

12 December 2020

Reversible and efficient activation of HIV-1 cell entry by a tyrosine-sulfated peptide dissects endocytic entry and inhibitor mechanisms

1 reference

12 December 2020

Quantification of CD4, CCR5, and CXCR4 levels on lymphocyte subsets, dendritic cells, and differentially conditioned monocyte-derived macrophages

1 reference

12 December 2020

Expression and characterization of a single-chain polypeptide analogue of the human immunodeficiency virus type 1 gp120-CD4 receptor complex

1 reference

12 December 2020

CD4-independent infection by HIV-2 is mediated by fusin/CXCR4.

1 reference

12 December 2020

Imaging of Protein Secretion from a Single Cell Using Plasmonic Substrates

1 reference

12 December 2020

Epitope mapping of CCR5 reveals multiple conformational states and distinct but overlapping structures involved in chemokine and coreceptor function

1 reference

12 December 2020

CCR5 small-molecule antagonists and monoclonal antibodies exert potent synergistic antiviral effects by cobinding to the receptor

1 reference

12 December 2020

Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development

1 reference

12 December 2020

CCR5-delta 32 gene deletion in HIV-1 infected patients

1 reference

12 December 2020

Neutralizing antibody and anti-retroviral drug sensitivities of HIV-1 isolates resistant to small molecule CCR5 inhibitors

1 reference

12 December 2020

Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection

1 reference

12 December 2020

Large Fluorescence Enhancements of Fluorophore Ensembles with Multilayer Plasmonic Substrates: Comparison of Theory and Experimental Results

1 reference

12 December 2020

Combined effect of CCR5-Delta32 heterozygosity and the CCR5 promoter polymorphism -2459 A/G on CCR5 expression and resistance to human immunodeficiency virus type 1 transmission

1 reference

12 December 2020

Detection of replication-competent and pseudotyped human immunodeficiency virus with a sensitive cell line on the basis of activation of an integrated beta-galactosidase gene

1 reference

12 December 2020

Characterization of recombinant human interleukin-2 with micromethods

1 reference

12 December 2020

Relationship between CCR5 density and viral load after discontinuation of antiretroviral therapy

1 reference

12 December 2020

A sensitive and specific enzyme-based assay detecting HIV-1 virion fusion in primary T lymphocytes

1 reference

12 December 2020

CCR5 levels and expression pattern correlate with infectability by macrophage-tropic HIV-1, in vitro

1 reference

12 December 2020

Structures of the CCR5 N Terminus and of a Tyrosine-Sulfated Antibody with HIV-1 gp120 and CD4

1 reference

12 December 2020

Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM)

1 reference

12 December 2020

1 reference

12 December 2020

Monocyte chemotactic protein-2 activates CCR5 and blocks CD4/CCR5-mediated HIV-1 entry/replication

1 reference

12 December 2020

Immunodeficiency virus rev trans-activator modulates the expression of the viral regulatory genes

1 reference

12 December 2020

HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5

1 reference

12 December 2020

Mechanisms of viral membrane fusion and its inhibition

1 reference

12 December 2020

Synergistic Inhibition of R5 HIV-1 by the Fusion Protein (FLSC) IgG1 Fc and Maraviroc in Primary Cells: Implications for Prevention and Treatment

1 reference

12 December 2020

Reduced maximal inhibition in phenotypic susceptibility assays indicates that viral strains resistant to the CCR5 antagonist maraviroc utilize inhibitor-bound receptor for entry

1 reference

12 December 2020

Variants of human immunodeficiency virus type 1 that efficiently use CCR5 lacking the tyrosine-sulfated amino terminus have adaptive mutations in gp120, including loss of a functional N-glycan

1 reference

12 December 2020

Cooperation of multiple CCR5 coreceptors is required for infections by human immunodeficiency virus type 1

1 reference

12 December 2020

10.1016/J.ANTIVIRAL.2014.10.006

Identifiers

DOI

1 reference

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23 February 2020

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23 February 2020

PubMed publication ID

25453341

1 reference

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