The cleavage pattern of TDP-43 determines its rate of clearance and cytotoxicity (Q38915658)

7 September 2017

title

The cleavage pattern of TDP-43 determines its rate of clearance and cytotoxicity (English)

1 reference

7 September 2017

0 references

Quan Li

1 reference

7 September 2017

Moe Yokoshi

series ordinal

1 reference

7 September 2017

Hitomi Okada

series ordinal

1 reference

7 September 2017

Yukio Kawahara

series ordinal

1 reference

7 September 2017

language of work or name

English

0 references

publication date

29 January 2015

1 reference

7 September 2017

published in

Nature Communications

1 reference

7 September 2017

1 reference

7 September 2017

page(s)

6183

1 reference

Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

7 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7183

TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7183

TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7183

TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7183

Caspase-cleaved TAR DNA-binding protein-43 is a major pathological finding in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7183

Expression of TDP-43 C-terminal Fragments in Vitro Recapitulates Pathological Features of TDP-43 Proteinopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7183

Truncation and pathogenic mutations facilitate the formation of intracellular aggregates of TDP-43.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7183

Understanding the role of TDP-43 and FUS/TLS in ALS and beyond.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7183

Pathological mechanisms underlying TDP-43 driven neurodegeneration in FTLD-ALS spectrum disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7183

Accelerated disease onset with stabilized familial amyotrophic lateral sclerosis (ALS)-linked mutant TDP-43 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7183

TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7183

A Drosophila model for TDP-43 proteinopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7183

Progranulin mediates caspase-dependent cleavage of TAR DNA binding protein-43.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7183

Characterization of alternative isoforms and inclusion body of the TAR DNA-binding protein-43.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7183

TDP-43-induced death is associated with altered regulation of BIM and Bcl-xL and attenuated by caspase-mediated TDP-43 cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7183

Reduced cellular Ca(2+) availability enhances TDP-43 cleavage by apoptotic caspases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7183

Molecular properties of TAR DNA binding protein-43 fragments are dependent upon its cleavage site

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7183

Proteolytic processing of TAR DNA binding protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7183

Redox signalling directly regulates TDP-43 via cysteine oxidation and disulphide cross-linking

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7183

Molecular mechanism of oxidation-induced TDP-43 RRM1 aggregation and loss of function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7183

Aberrant assembly of RNA recognition motif 1 links to pathogenic conversion of TAR DNA-binding protein of 43 kDa (TDP-43)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7183

Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7183

TDP-43 toxicity proceeds via calcium dysregulation and necrosis in aging Caenorhabditis elegans motor neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7183

Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7183

ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7183

Phosphorylated and ubiquitinated TDP-43 pathological inclusions in ALS and FTLD-U are recapitulated in SH-SY5Y cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7183

Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7183

Cell stress induces TDP-43 pathological changes associated with ERK1/2 dysfunction: implications in ALS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7183

ALS-associated TDP-43 induces endoplasmic reticulum stress, which drives cytoplasmic TDP-43 accumulation and stress granule formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7183

TDP-43 toxicity is mediated by the unfolded protein response-unrelated induction of C/EBP homologous protein expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7183

Endoplasmic reticulum stress and induction of the unfolded protein response in human sporadic amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7183

Endoplasmic reticulum stress-induced caspase-4 activation mediates apoptosis and neurodegeneration in INCL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7183

Presenilin-1 mutation activates the signaling pathway of caspase-4 in endoplasmic reticulum stress-induced apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7183

Motor neuron-specific disruption of proteasomes, but not autophagy, replicates amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7183

Differential roles of the ubiquitin proteasome system and autophagy in the clearance of soluble and aggregated TDP-43 species

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7183

Metabolism and mis-metabolism of the neuropathological signature protein TDP-43.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7183

The crystal structure of TDP-43 RRM1-DNA complex reveals the specific recognition for UG- and TG-rich nucleic acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7183

Disease causing mutants of TDP-43 nucleic acid binding domains are resistant to aggregation and have increased stability and half-life

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7183

Caspase-4 and caspase-5, members of the ICE/CED-3 family of cysteine proteases, are CrmA-inhibitable proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7183

TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7183

Oxidative and endoplasmic reticulum stress interplay in sporadic amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7183

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NCOMMS7183

1 reference

Dimensions Publication ID

7 September 2017

0 references

1022414785

0 references

1 reference