Contribution of membrane trafficking perturbation to retinal toxicity (Q38900019)

7 September 2017

title

Contribution of membrane trafficking perturbation to retinal toxicity (English)

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7 September 2017

Su Khoh-Reiter

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7 September 2017

Sharon A Sokolowski

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7 September 2017

Bart Jessen

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7 September 2017

Mark Evans

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7 September 2017

Deepak Dalvie

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7 September 2017

Shuyan Lu

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7 September 2017

publication date

13 March 2015

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7 September 2017

published in

Toxicological Sciences

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7 September 2017

volume

145

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7 September 2017

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7 September 2017

page(s)

383-395

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Irreversible lysosomal damage induced by chloroquine in the retinae of pigmented and albino rats

7 September 2017

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Age and disease-related structural changes in the retinal pigment epithelium

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Dysfunction of the retinal pigment epithelium with age: increased iron decreases phagocytosis and lysosomal activity

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Chloroquine treatment of ARPE-19 cells leads to lysosome dilation and intracellular lipid accumulation: possible implications of lysosomal dysfunction in macular degeneration

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Macroautophagy is defective in mucolipin-1-deficient mouse neurons

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Commentary. Lysosomotropic agents

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Chloroquine-induced lipidosis in the rat retina: functional and morphological changes after withdrawal of the drug

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Differences in the retinotoxic action of chloroquine and phenothiazine derivatives

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Ultrastructural alterations in rat and cat retina and pigment epithelium induced by chloroquine

21 January 2018

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Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration

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Involvement of two different cell death pathways in retinal atrophy of cathepsin D-deficient mice

21 January 2018

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Identification of novel functional inhibitors of acid sphingomyelinase

21 January 2018

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Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model

21 January 2018

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Quantitation of the lysosomotropic character of cationic amphiphilic drugs using the fluorescent basic amine Red DND-99.

21 January 2018

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Drug-induced ocular disorders

21 January 2018

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Evaluating the roles of autophagy and lysosomal trafficking defects in intracellular distribution-based drug-drug interactions involving lysosomes

21 January 2018

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Amine-containing molecules and the induction of an expanded lysosomal volume phenotype: a structure-activity relationship study

21 January 2018

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Retinal lipidosis in albino rats treated with chlorphentermine and with tricyclic antidepressants

21 January 2018

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Chloroquine causes lysosomal dysfunction in neural retina and RPE: implications for retinopathy

21 January 2018

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Tissue distribution of chloroquine, hydroxychloroquine, and desethylchloroquine in the rat

21 January 2018

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An overview on the toxic morphological changes in the retinal pigment epithelium after systemic compound administration

21 January 2018

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Lysosomal membrane permeability stimulates protein aggregate formation in neurons of a lysosomal disease

21 January 2018

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Autophagy-dependent rhodopsin degradation prevents retinal degeneration in Drosophila.

21 January 2018

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A high content screening assay for identifying lysosomotropic compounds

21 January 2018

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Retinal ultrastructure of murine models of dry age-related macular degeneration (AMD).

21 January 2018

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Chloroquine accumulation in isolated rat liver lysosomes

21 January 2018

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Crosstalk between Hsp70 molecular chaperone, lysosomes and proteasomes in autophagy-mediated proteolysis in human retinal pigment epithelial cells

21 January 2018

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A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

21 January 2018

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The retinal pigment epithelium in visual function

21 January 2018

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Ocular manifestations as key features for diagnosing mucopolysaccharidoses

21 January 2018

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Lysosomotropic agents: impact on lysosomal membrane permeabilization and cell death

21 January 2018

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δ-Tocopherol reduces lipid accumulation in Niemann-Pick type C1 and Wolman cholesterol storage disorders

21 January 2018

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A phenotypic compound screening assay for lysosomal storage diseases

21 January 2018

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21 January 2018

Identifiers

DOI

10.1093/TOXSCI/KFV059

1 reference

7 September 2017

1 reference