C6 ceramide sensitizes the anti-hepatocellular carcinoma (HCC) activity by AZD-8055, a novel mTORC1/2 dual inhibitor (Q38792344)

6 September 2017

title

C6 ceramide sensitizes the anti-hepatocellular carcinoma (HCC) activity by AZD-8055, a novel mTORC1/2 dual inhibitor (English)

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6 September 2017

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ChEBI release 2020-05-28

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Mo Liu

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6 September 2017

Peng Gu

series ordinal

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6 September 2017

Wenjia Guo

series ordinal

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6 September 2017

Xiwen Fan

series ordinal

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6 September 2017

publication date

20 February 2016

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

page(s)

11039-11048

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Hepatocellular carcinoma pathogenesis: from genes to environment

6 September 2017

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Inhibition of mTORC2 Induces Cell-Cycle Arrest and Enhances the Cytotoxicity of Doxorubicin by Suppressing MDR1 Expression in HCC Cells

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The dual mTORC1 and mTORC2 inhibitor AZD8055 inhibits head and neck squamous cell carcinoma cell growth in vivo and in vitro

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C6 ceramide dramatically increases vincristine sensitivity both in vivo and in vitro, involving AMP-activated protein kinase-p53 signaling

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Exogenous cell-permeable C6 ceramide sensitizes multiple cancer cell lines to Doxorubicin-induced apoptosis by promoting AMPK activation and mTORC1 inhibition

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C6 ceramide dramatically enhances docetaxel-induced growth inhibition and apoptosis in cultured breast cancer cells: a mechanism study

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C6 ceramide potentiates curcumin-induced cell death and apoptosis in melanoma cell lines in vitro

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Coadministration of histone deacetylase inhibitors and perifosine synergistically induces apoptosis in human leukemia cells through Akt and ERK1/2 inactivation and the generation of ceramide and reactive oxygen species

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C6-ceramide synergistically potentiates the anti-tumor effects of histone deacetylase inhibitors via AKT dephosphorylation and α-tubulin hyperacetylation both in vitro and in vivo

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Primary human hepatocytes--a valuable tool for investigation of apoptosis and hepatitis B virus infection

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P53 dependent mitochondrial permeability transition pore opening is required for dexamethasone-induced death of osteoblasts

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Resveratrol protects DAergic PC12 cells from high glucose-induced oxidative stress and apoptosis: effect on p53 and GRP75 localization

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12 December 2020

Galpha(i1) and Galpha(i3) are required for epidermal growth factor-mediated activation of the Akt-mTORC1 pathway

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12 December 2020

Epirubicin directly promotes hepatitis B virus (HBV) replication in stable HBV-expressing cell lines: a novel mechanism of HBV reactivation following anticancer chemotherapy

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12 December 2020

Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer

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12 December 2020

10.1007/S13277-015-4598-1

Identifiers

DOI

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Dimensions Publication ID

6 September 2017

1025457331

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