The importance of p53 pathway genetics in inherited and somatic cancer genomes. (Q38786667)

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30 March 2020

title

The importance of p53 pathway genetics in inherited and somatic cancer genomes (English)

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Benjamin Schuster-Böckler

30 March 2020

author

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Giovanni Stracquadanio

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30 March 2020

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30 March 2020

Francesc Castro-giner

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30 March 2020

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30 March 2020

William G Fairbrother

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30 March 2020

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30 March 2020

Ian P Tomlinson

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30 March 2020

Douglas A Bell

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Marsha D Wallace

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30 March 2020

Anna M Grawenda

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30 March 2020

Ping Zhang

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30 March 2020

Juliet Hewitt

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30 March 2020

Kamil J Cygan

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30 March 2020

Federica Gemignani

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30 March 2020

Stefano Landi

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30 March 2020

Gareth L Bond

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30 March 2020

language of work or name

English

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publication date

1 April 2016

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30 March 2020

published in

Nature Reviews Cancer

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30 March 2020

volume

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issue

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30 March 2020

page(s)

251-265

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30 March 2020

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20 years studying p53 functions in genetically engineered mice

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A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain

31 March 2020

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12 December 2020

ΔNp63 expression is associated with poor survival in ovarian cancer

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Mammary tumorigenesis following transgenic expression of a dominant negative CHK2 mutant

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Tumor spectrum in ARF-deficient mice.

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p53 has a direct apoptogenic role at the mitochondria

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Gene amplification CCNE1 is related to poor survival and potential therapeutic target in ovarian cancer

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Mice with the CHEK2*1100delC SNP are predisposed to cancer with a strong gender bias

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Regulation of the G2/M transition by p53.

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Hepatocellular carcinoma results from chronic cyclin D1 overexpression in transgenic mice

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BCL2 mutations in diffuse large B-cell lymphoma

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Alternate splicing produces a novel cyclin D1 transcript

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p63 and p73, the ancestors of p53.

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Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription

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12 December 2020

p53 suppresses the activation of the Bcl-2 promoter by the Brn-3a POU family transcription factor

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12 December 2020

Atm knock-in mice harboring an in-frame deletion corresponding to the human ATM 7636del9 common mutation exhibit a variant phenotype

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRC.2016.15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27009395%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

30 March 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27009395%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

PubMed publication ID

27009395

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27009395%20AND%20SRC:MED&resulttype=core&format=json