Hsp90 in Cancer: Transcriptional Roles in the Nucleus. (Q38750421)

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scientific article published on 12 October 2015

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English	Hsp90 in Cancer: Transcriptional Roles in the Nucleus.	scientific article published on 12 October 2015

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scholarly article

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Europe PubMed Central

PubMed publication ID

26916002

retrieved

6 September 2017

title

Hsp90 in Cancer: Transcriptional Roles in the Nucleus (English)

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Europe PubMed Central

PMC publication ID

6790218

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6790218&resulttype=core&format=json

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12 May 2020

author

Len Neckers

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2

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Len Neckers

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Europe PubMed Central

PMC publication ID

6790218

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12 May 2020

author name string

Stuart K Calderwood

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1

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Europe PubMed Central

PMC publication ID

6790218

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6790218&resulttype=core&format=json

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12 May 2020

publication date

12 October 2015

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Europe PubMed Central

PubMed publication ID

26916002

retrieved

6 September 2017

published in

Advances in Cancer Research

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Europe PubMed Central

PMC publication ID

6790218

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6790218&resulttype=core&format=json

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12 May 2020

volume

129

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Europe PubMed Central

PMC publication ID

6790218

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6790218&resulttype=core&format=json

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12 May 2020

page(s)

89-106

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Europe PubMed Central

PMC publication ID

6790218

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6790218&resulttype=core&format=json

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12 May 2020

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SUMOylation in carcinogenesis

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Targeting the oncogene and kinome chaperone CDC37.

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Molecular cochaperones: tumor growth and cancer treatment

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TRANSCRIPTION. Recruitment of RNA polymerase II by the pioneer transcription factor PHA-4.

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HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers

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P-TEFb kinase recruitment and function at heat shock loci

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Expression of heat shock proteins and heat shock protein messenger ribonucleic acid in human prostate carcinoma in vitro and in tumors in vivo.

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The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties

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The MLL3/MLL4 branches of the COMPASS family function as major histone H3K4 monomethylases at enhancers

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Pol II docking and pausing at growth and stress genes in C. elegans

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Phosphorylation analysis of 90 kDa heat shock protein within the cytosolic arylhydrocarbon receptor complex

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Activator control of nucleosome occupancy in activation and repression of transcription

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Chaperone regulation of the heat shock protein response

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A new effector pathway links ATM kinase with the DNA damage response

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Post-translational modifications of Hsp90 and their contributions to chaperone regulation

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The heat-shock proteins

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Glucocorticoid receptor function regulated by coordinated action of the Hsp90 and Hsp70 chaperone cycles

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Reduced levels of hsp90 compromise steroid receptor action in vivo

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Trithorax requires Hsp90 for maintenance of active chromatin at sites of gene expression

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Relief of two built-In autoinhibitory mechanisms in P-TEFb is required for assembly of a multicomponent transcription elongation complex at the human immunodeficiency virus type 1 promoter

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Heat shock protein 90.

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Analysis of genetic mosaics in developing and adult Drosophila tissues

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Casein kinase 2 phosphorylation of Hsp90 threonine 22 modulates chaperone function and drug sensitivity

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Threonine 22 phosphorylation attenuates Hsp90 interaction with cochaperones and affects its chaperone activity

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SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells

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A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors

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Asymmetric Hsp90 N domain SUMOylation recruits Aha1 and ATP-competitive inhibitors

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Heat shock proteins and heat shock factor 1 in carcinogenesis and tumor development: an update

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The human double-stranded DNA-activated protein kinase phosphorylates the 90-kDa heat-shock protein, hsp90 alpha at two NH2-terminal threonine residues

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12 December 2020

based on heuristic

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Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1

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Hsp90 isoforms: functions, expression and clinical importance

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Sequential phosphorylation by mitogen-activated protein kinase and glycogen synthase kinase 3 represses transcriptional activation by heat shock factor-1

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PubMed

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based on heuristic

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Heat shock protein 90α (HSP90α), a substrate and chaperone of DNA-PK necessary for the apoptotic response

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/26916002

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/26916002

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12 December 2020

based on heuristic

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Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/26916002

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12 December 2020

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The SUMO system: a master organizer of nuclear protein assemblies.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/26916002

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase CK2 in health and disease: Cellular functions of protein kinase CK2: a dynamic affair.

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/26916002

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of glucocorticoid receptor activity by a stress responsive transcriptional cofactor.

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/26916002

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Double strand break (DSB) repair in heterochromatin and heterochromatin proteins in DSB repair

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/26916002

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Promoter-proximal pausing of RNA polymerase II: emerging roles in metazoans

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/26916002

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of KRAB-associated protein 1 (KAP1) at Tyr-449, Tyr-458, and Tyr-517 by nuclear tyrosine kinases inhibits the association of KAP1 and heterochromatin protein 1α (HP1α) with heterochromatin

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/26916002

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TRIM28 regulates RNA polymerase II promoter-proximal pausing and pause release

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/26916002

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Requirement for a kinase-specific chaperone pathway in the production of a Cdk9/cyclin T1 heterodimer responsible for P-TEFb-mediated tat stimulation of HIV-1 transcription

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/26916002

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The human RVB complex is required for efficient transcription of type I interferon-stimulated genes.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/26916002

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12 December 2020

based on heuristic

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High-wire act: the poised genome and cellular memory.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/26916002

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12 December 2020

based on heuristic

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Modulation of heat shock gene expression by the TAC1 chromatin-modifying complex.

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/26916002

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12 December 2020

based on heuristic

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Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/26916002

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12 December 2020

based on heuristic

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Tight coordination of protein translation and HSF1 activation supports the anabolic malignant state

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/26916002

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HSP90 and its R2TP/Prefoldin-like cochaperone are involved in the cytoplasmic assembly of RNA polymerase II

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/26916002

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12 December 2020

based on heuristic

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The C-terminal half of Hsp90 is responsible for its cytoplasmic localization

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/26916002

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hsp90 affecting chromatin remodeling might explain transgenerational epigenetic inheritance in Drosophila

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https://pubmed.ncbi.nlm.nih.gov/26916002

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12 December 2020

based on heuristic

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Nuclear translocation of the Hsp70/Hsp90 organizing protein mSTI1 is regulated by cell cycle kinases.

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https://pubmed.ncbi.nlm.nih.gov/26916002

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cancer COMPASS: navigating the functions of MLL complexes in cancer

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/26916002

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heat shock transcription factors: structure and regulation

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/26916002

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase CK2 in breast cancer: the CK2β regulatory subunit takes center stage in epithelial plasticity

1 reference

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https://pubmed.ncbi.nlm.nih.gov/26916002

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12 December 2020

based on heuristic

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Transcriptional activity and DNA binding of heat shock factor-1 involve phosphorylation on threonine 142 by CK2

1 reference

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reference URL

https://pubmed.ncbi.nlm.nih.gov/26916002

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12 December 2020

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Ligand-dependent enhancer activation regulated by topoisomerase-I activity

1 reference

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https://pubmed.ncbi.nlm.nih.gov/26916002

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12 December 2020

based on heuristic

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Targeting the dynamic HSP90 complex in cancer

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https://pubmed.ncbi.nlm.nih.gov/26916002

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A breaking strategy for topoisomerase IIbeta/PARP-1-dependent regulated transcription

1 reference

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https://pubmed.ncbi.nlm.nih.gov/26916002

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The therapeutic target Hsp90 and cancer hallmarks

1 reference

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reference URL

https://pubmed.ncbi.nlm.nih.gov/26916002

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hsp90 globally targets paused RNA polymerase to regulate gene expression in response to environmental stimuli

1 reference

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https://pubmed.ncbi.nlm.nih.gov/26916002

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12 December 2020

based on heuristic

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Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the hsp90 chaperone

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https://pubmed.ncbi.nlm.nih.gov/26916002

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Src-mediated phosphorylation of Hsp90 in response to vascular endothelial growth factor (VEGF) is required for VEGF receptor-2 signaling to endothelial NO synthase.

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/26916002

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of changes in SUMO-2/3 modification during breast cancer progression and metastasis

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/26916002

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of serine 303 is a prerequisite for the stress-inducible SUMO modification of heat shock factor 1

1 reference

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reference URL

https://pubmed.ncbi.nlm.nih.gov/26916002

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12 December 2020

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Transcriptional activity of heat shock factor 1 at 37 degrees C is repressed through phosphorylation on two distinct serine residues by glycogen synthase kinase 3 and protein kinases Calpha and Czeta

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/26916002

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase CK2 in health and disease: CK2: the kinase controlling the Hsp90 chaperone machinery

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/26916002

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Folding of the glucocorticoid receptor by the reconstituted Hsp90-based chaperone machinery. The initial hsp90.p60.hsp70-dependent step is sufficient for creating the steroid binding conformation

1 reference

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reference URL

https://pubmed.ncbi.nlm.nih.gov/26916002

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rearrangement of the MLL gene in acute lymphoblastic and acute myeloid leukemias with 11q23 chromosomal translocations

1 reference

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https://pubmed.ncbi.nlm.nih.gov/26916002

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based on heuristic

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Cracking the RNA polymerase II CTD code

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https://pubmed.ncbi.nlm.nih.gov/26916002

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12 December 2020

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Identifiers

DOI

10.1016/BS.ACR.2015.08.002

1 reference

stated in

Europe PubMed Central

PMC publication ID

6790218

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6790218&resulttype=core&format=json

retrieved

12 May 2020

PMC publication ID

6790218

1 reference

stated in

Europe PubMed Central

PMC publication ID

6790218

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6790218&resulttype=core&format=json

retrieved

12 May 2020

PubMed publication ID

26916002

1 reference

stated in

Europe PubMed Central

PMC publication ID

6790218

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6790218&resulttype=core&format=json

retrieved

12 May 2020

 

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