Assessment of the PD-L1 status by immunohistochemistry: challenges and perspectives for therapeutic strategies in lung cancer patients (Q38749966)

6 September 2017

title

Assessment of the PD-L1 status by immunohistochemistry: challenges and perspectives for therapeutic strategies in lung cancer patients (English)

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6 September 2017

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Jean-Charles Soria

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Manfred Dietel

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object named as

Manfred Dietel

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6 September 2017

Marius Ilie

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6 September 2017

Véronique Hofman

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6 September 2017

Paul Hofman

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6 September 2017

publication date

25 February 2016

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6 September 2017

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6 September 2017

volume

468

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6 September 2017

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6 September 2017

page(s)

511-525

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describes a project that uses

6 September 2017

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European cancer mortality predictions for the year 2015: does lung cancer have the highest death rate in EU women?

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Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer

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PD-L1 regulates the development, maintenance, and function of induced regulatory T cells

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Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma

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Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1).

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Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape

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Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients

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Activation of the PD-1 pathway contributes to immune escape in EGFR-driven lung tumors

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PD-1 blockade induces responses by inhibiting adaptive immune resistance

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Adaptive Immune Resistance: How Cancer Protects from Immune Attack

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Up-regulation of PD-L1, IDO, and T(regs) in the melanoma tumor microenvironment is driven by CD8(+) T cells

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PD-L1 blockade for cancer treatment: MEDI4736.

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PD-1/PD-L1 inhibitors.

1 reference

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Benefit-Risk Summary of Nivolumab for Patients With Metastatic Squamous Cell Lung Cancer After Platinum-Based Chemotherapy: A Report From the US Food and Drug Administration

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Nivolumab versus Docetaxel in Advanced Nonsquamous Non-Small-Cell Lung Cancer

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Anti-PD-1/PD-L1 therapy of human cancer: past, present, and future.

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Quantitative Assessment of the Heterogeneity of PD-L1 Expression in Non-Small-Cell Lung Cancer

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Programmed death ligand-1 expression in non-small cell lung cancer

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A mechanism of hypoxia-mediated escape from adaptive immunity in cancer cells

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PD-L1 Expression as a Predictive Biomarker in Cancer Immunotherapy

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Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer

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Incorporating immune-checkpoint inhibitors into systemic therapy of NSCLC

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Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapy

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PD-L1-deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells

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B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion

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Sarcomatoid lung carcinomas show high levels of programmed death ligand-1 (PD-L1).

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B7-H1 expression on non-small cell lung cancer cells and its relationship with tumor-infiltrating lymphocytes and their PD-1 expression

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Programmed cell death-ligand 1 expression in surgically resected stage I pulmonary adenocarcinoma and its correlation with driver mutations and clinical outcomes.

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Comparative study of the PD-L1 status between surgically resected specimens and matched biopsies of NSCLC patients reveal major discordances: a potential issue for anti-PD-L1 therapeutic strategies

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Quantitative analysis of tumor in bronchial biopsy specimens

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10.1007/S00428-016-1910-4

Identifiers

DOI

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6 September 2017

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