PLCgamma2 regulates osteoclastogenesis via its interaction with ITAM proteins and GAB2. (Q38744013)

6 September 2017

PLCgamma2 regulates osteoclastogenesis via its interaction with ITAM proteins and GAB2. (English)

1 reference

ORCID Public Data File 2021

6 September 2017

Deborah V Novack

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author name string

Dailing Mao

1 reference

6 September 2017

Holly Epple

1 reference

6 September 2017

Brian Uthgenannt

1 reference

6 September 2017

Roberta Faccio

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6 September 2017

language of work or name

English

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publication date

19 October 2006

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Journal of Clinical Investigation

6 September 2017

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6 September 2017

116

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6 September 2017

1 reference

6 September 2017

2869-2879

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Biologic therapies in clinical development for the treatment of rheumatoid arthritis

6 September 2017

1 reference

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Role of RANKL in physiological and pathological bone resorption and therapeutics targeting the RANKL-RANK signaling system

6 September 2017

1 reference

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M-CSF mediates TNF-induced inflammatory osteolysis

6 September 2017

1 reference

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I{kappa}B kinase (IKK){beta}, but not IKK{alpha}, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1616195

The molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1616195

Critical roles of c-Jun signaling in regulation of NFAT family and RANKL-regulated osteoclast differentiation

6 September 2017

1 reference

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The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcRgamma) regulate development of functional osteoclasts through the Syk tyrosine kinase

6 September 2017

1 reference

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Dynamic changes in the osteoclast cytoskeleton in response to growth factors and cell attachment are controlled by beta3 integrin

6 September 2017

1 reference

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Genetic regulation of osteoclast development and function

6 September 2017

1 reference

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Osteopetrosis and thalamic hypomyelinosis with synaptic degeneration in DAP12-deficient mice

6 September 2017

1 reference

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Protein-tyrosine kinases and adaptor proteins in FcepsilonRI-mediated signaling in mast cells

6 September 2017

1 reference

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Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts

6 September 2017

1 reference

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6 September 2017

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The adapter molecule Gab2 regulates Fc epsilon RI-mediated signal transduction in mast cells

6 September 2017

1 reference

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Regulation of phospholipase C gamma isoforms in haematopoietic cells: why one, not the other?

6 September 2017

1 reference

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TNF-alpha induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand

6 September 2017

1 reference

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Bone versus immune system

6 September 2017

1 reference

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Mechanisms of bone loss in inflammatory arthritis: diagnosis and therapeutic implications

6 September 2017

1 reference

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Structure, function, and control of phosphoinositide-specific phospholipase C

6 September 2017

1 reference

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Cutting edge: essential role of phospholipase C-gamma 2 in B cell development and function

6 September 2017

1 reference

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Requirement for NF-κB in osteoclast and B-cell development

6 September 2017

1 reference

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Essential role of the tyrosine kinase substrate phospholipase C-gamma1 in mammalian growth and development

6 September 2017

1 reference

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Evidence for a role for tyrosine phosphorylation of phospholipase C gamma 2 in collagen-induced platelet cytosolic calcium mobilization

6 September 2017

1 reference

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Phospholipase C-gamma 1 can induce DNA synthesis by a mechanism independent of its lipase activity

6 September 2017

1 reference

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New insights into the families of PLC enzymes: looking back and going forward

6 September 2017

1 reference

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c-Fms and the alphavbeta3 integrin collaborate during osteoclast differentiation

6 September 2017

1 reference

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The signaling adapter protein DAP12 regulates multinucleation during osteoclast development

14 September 2017

1 reference

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B-cell antigen receptor activates transcription factors NFAT (nuclear factor of activated T-cells) and NF-kappaB (nuclear factor kappaB) via a mechanism that involves diacylglycerol

14 September 2017

1 reference

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IL-1 mediates TNF-induced osteoclastogenesis

14 September 2017

1 reference

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Osteoclast activation in inflammatory periodontal diseases

25 September 2017

1 reference

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Selective inhibition of NF-kappa B blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo

25 September 2017

1 reference

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Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis

23 June 2018

1 reference

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Tumor necrosis factor-alpha (TNF) stimulates RANKL-induced osteoclastogenesis via coupling of TNF type 1 receptor and RANK signaling pathways

23 June 2018

1 reference

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Antigen receptor signaling: integration of protein tyrosine kinase functions.

23 June 2018

1 reference

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Osteopetrosis in mice lacking NF-κB1 and NF-κB2

23 June 2018

1 reference

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Autoamplification of NFATc1 expression determines its essential role in bone homeostasis

23 June 2018

1 reference

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Phospholipase C-gamma 2 is a critical signaling mediator for murine NK cell activating receptors

31 August 2018

1 reference

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Autoimmunity and inflammation due to a gain-of-function mutation in phospholipase C gamma 2 that specifically increases external Ca2+ entry

31 August 2018

1 reference

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Joint erosion in rheumatoid arthritis: interactions between tumour necrosis factor alpha, interleukin 1, and receptor activator of nuclear factor kappaB ligand (RANKL) regulate osteoclasts

31 August 2018

1 reference

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High dose M-CSF partially rescues the Dap12-/- osteoclast phenotype

31 August 2018

1 reference

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Interleukin-4 Reversibly Inhibits Osteoclastogenesis via Inhibition of NF-κB and Mitogen-activated Protein Kinase Signaling

31 August 2018

1 reference

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Involvement of receptor activator of nuclear factor kappaB ligand/osteoclast differentiation factor in osteoclastogenesis from synoviocytes in rheumatoid arthritis

3 December 2018

1 reference

12 December 2020

Phospholipase Cgamma2 is essential in the functions of B cell and several Fc receptors

1 reference

12 December 2020

JNK1 modulates osteoclastogenesis through both c-Jun phosphorylation-dependent and -independent mechanisms

1 reference

12 December 2020

The IkappaB kinase (IKK) inhibitor, NEMO-binding domain peptide, blocks osteoclastogenesis and bone erosion in inflammatory arthritis

1 reference

12 December 2020

Inhibition of phospholipase C dependent processes by U-73, 122

1 reference

12 December 2020

Fcγ receptor II stimulated formation of inositol phosphates in human platelets is blocked by tyrosine kinase inhibitors and associated with tyrosine phosphorylation of the receptor

1 reference

12 December 2020

c-Fos: a key regulator of osteoclast-macrophage lineage determination and bone remodeling

1 reference

12 December 2020

Families of phosphoinositide-specific phospholipase C: structure and function

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI28775

1 reference

6 September 2017

1 reference

6 September 2017

PubMed publication ID

17053833

1 reference